SCI Regeneration MapWhat the world knows about repairing the injured spinal cord

Seven directions of research against twelve things that matter

Most research is measured by walking. A person asks about their hands, their bladder, their pain and their safety too. Every cell below either has evidence, or says it was searched and nothing was found — and those are different answers.

What a person has checked

These are two different numbers and this page will never merge them. A machine can find a paper, read it and propose what it says. Whether that is true of the science is a judgement a person makes, one record at a time — and until they do, it is not evidence.

  • Checked by a person: 0 — Counted from signatures: a record whose decision in force is an approval a person made inside their own live working session. A decision made by a script is not counted, and no setting can claim otherwise.
  • Checked against a primary source, not by a person: 29 — Counted from signatures: a record whose decision in force is an approval recorded by the evidence-review assistant the owner named in advance and authorised in writing, naming the trial-registry record, PubMed record or DOI it was checked against. It is not a person’s verdict, and this product is not medical advice.
  • Read by a machine, waiting for a person: 0
  • Rejected by a person: 0
  • Deferred by a person: 0
  • Registered, results never posted: 0
  • Searched, nothing found: 0
  • Search not finished: 84

What the map actually holds

Finding a paper is not the same as checking what it found. Below, every cell says which of five things is true of it — and "we searched and found nothing", "the trial never posted its results" and "we have not finished looking" are three different answers, never one blank space.

Documents, studies, measurements, claims and technologies are counted separately on purpose: one trial posting sixty measures and sixty papers reporting one each are the same total and very different bodies of evidence.

  • Documents read: 117
  • Studies: 57
  • Measurements: 98
  • Claims: 33
  • Positions of a measurement on a claim: 31
  • Claim contexts: 31
  • Technologies attached: 0
  • Waiting for a person: 0
  • Registered, results never posted: 0
  • Searches that found nothing: 0
  • Selected, not yet read: 0

No study here is attached to a technology. Which technology a study tested is a judgement a person makes, and attaching them by machine would manufacture evidence for technologies these papers never studied.

The five answers

  • Checked evidence
  • Records under review
  • Results never posted
  • Searched, nothing found
  • Search not finished
Direction of researchWalking and standingArm and handSensationSense of body positionPainBladderBowelSexual functionAutonomic regulationBreathingEveryday independenceSafety and complications
Mapping the injury0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished
Scar and matrix0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished
Bridging the gap0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished
Rebuilding cells0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished
Regrowing axons0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished
Reconnecting around it0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished
Retraining what remains0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished0 Search not finished

Which sources were carried the whole way, and why

The selection is a set named in advance, not a handful somebody picked. Each rule below says what it is for, and how many records it chose. A rule that chose nothing still appears — that is a finding too.

    What the machine read, not yet checked by a person

    read by a machine — not yet checked by a person

    Nothing below has been checked by a person. It is shown because hiding it would waste a real records read and would hide the refusals too — and the refusals are the most useful part of it.

        How to read this

        A cell that was searched and came back empty is a finding about the literature. A cell nobody has searched yet is a finding about this map. They are never shown as the same thing.

        • Evidence found
        • Searched, found nothing
        • Not searched yet
        Direction of researchWalking and standingArm and handSensationSense of body positionPainBladderBowelSexual functionAutonomic regulationBreathingEveryday independenceSafety and complications
        Mapping the injury0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet
        Scar and matrix0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet
        Bridging the gap0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet
        Rebuilding cells0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet
        Regrowing axons0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet
        Reconnecting around it0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet
        Retraining what remains0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet0 Not searched yet

        Where the evidence is missing

        Ordered by which kind of gap it is. Where we searched and found nothing, the search terms are shown, so somebody who knows better can tell us the search was wrong.

        • Bridging the gap · Autonomic regulation

          Not searched yet

          Blood pressure, temperature and autonomic dysreflexia — the outcomes that are dangerous rather than inconvenient.

        • Bridging the gap · Bladder

          Not searched yet

          Bladder storage, emptying and continence — a daily determinant of health and of whether a person can leave the house.

        • Bridging the gap · Bowel

          Not searched yet

          Bowel management and continence, which govern how many hours of a day belong to care rather than to living.

        • Bridging the gap · Everyday independence

          Not searched yet

          Everyday independence: transfers, dressing, self-care — what a person can do without another person in the room.

        • Bridging the gap · Walking and standing

          Not searched yet

          Standing and walking, with or without help — the outcome most research is measured by, and only one of twelve.

        • Bridging the gap · Pain

          Not searched yet

          Neuropathic and musculoskeletal pain, including pain that appears after function returns.

        • Bridging the gap · Sense of body position

          Not searched yet

          Knowing where a limb is without looking at it, which is what makes movement usable rather than merely possible.

        • Bridging the gap · Breathing

          Not searched yet

          Breathing, cough and ventilator independence, which decide survival after a high cervical injury.

        • Bridging the gap · Safety and complications

          Not searched yet

          Adverse events, complications and harms — the outcome an intervention is refused for, and the one most easily left out of a summary.

        • Bridging the gap · Sensation

          Not searched yet

          Feeling touch, temperature and pressure — the difference between a wound noticed and a wound found later.

        • Bridging the gap · Sexual function

          Not searched yet

          Sexual function and fertility, asked about constantly and reported on rarely.

        • Bridging the gap · Arm and hand

          Not searched yet

          Hand and arm: grip, reach, release. For a cervical injury this is usually the first thing a person asks about.

        • Mapping the injury · Autonomic regulation

          Not searched yet

          Blood pressure, temperature and autonomic dysreflexia — the outcomes that are dangerous rather than inconvenient.

        • Mapping the injury · Bladder

          Not searched yet

          Bladder storage, emptying and continence — a daily determinant of health and of whether a person can leave the house.

        • Mapping the injury · Bowel

          Not searched yet

          Bowel management and continence, which govern how many hours of a day belong to care rather than to living.

        • Mapping the injury · Everyday independence

          Not searched yet

          Everyday independence: transfers, dressing, self-care — what a person can do without another person in the room.

        • Mapping the injury · Walking and standing

          Not searched yet

          Standing and walking, with or without help — the outcome most research is measured by, and only one of twelve.

        • Mapping the injury · Pain

          Not searched yet

          Neuropathic and musculoskeletal pain, including pain that appears after function returns.

        • Mapping the injury · Sense of body position

          Not searched yet

          Knowing where a limb is without looking at it, which is what makes movement usable rather than merely possible.

        • Mapping the injury · Breathing

          Not searched yet

          Breathing, cough and ventilator independence, which decide survival after a high cervical injury.

        • Mapping the injury · Safety and complications

          Not searched yet

          Adverse events, complications and harms — the outcome an intervention is refused for, and the one most easily left out of a summary.

        • Mapping the injury · Sensation

          Not searched yet

          Feeling touch, temperature and pressure — the difference between a wound noticed and a wound found later.

        • Mapping the injury · Sexual function

          Not searched yet

          Sexual function and fertility, asked about constantly and reported on rarely.

        • Mapping the injury · Arm and hand

          Not searched yet

          Hand and arm: grip, reach, release. For a cervical injury this is usually the first thing a person asks about.

        • Rebuilding cells · Autonomic regulation

          Not searched yet

          Blood pressure, temperature and autonomic dysreflexia — the outcomes that are dangerous rather than inconvenient.

        • Rebuilding cells · Bladder

          Not searched yet

          Bladder storage, emptying and continence — a daily determinant of health and of whether a person can leave the house.

        • Rebuilding cells · Bowel

          Not searched yet

          Bowel management and continence, which govern how many hours of a day belong to care rather than to living.

        • Rebuilding cells · Everyday independence

          Not searched yet

          Everyday independence: transfers, dressing, self-care — what a person can do without another person in the room.

        • Rebuilding cells · Walking and standing

          Not searched yet

          Standing and walking, with or without help — the outcome most research is measured by, and only one of twelve.

        • Rebuilding cells · Pain

          Not searched yet

          Neuropathic and musculoskeletal pain, including pain that appears after function returns.

        • Rebuilding cells · Sense of body position

          Not searched yet

          Knowing where a limb is without looking at it, which is what makes movement usable rather than merely possible.

        • Rebuilding cells · Breathing

          Not searched yet

          Breathing, cough and ventilator independence, which decide survival after a high cervical injury.

        • Rebuilding cells · Safety and complications

          Not searched yet

          Adverse events, complications and harms — the outcome an intervention is refused for, and the one most easily left out of a summary.

        • Rebuilding cells · Sensation

          Not searched yet

          Feeling touch, temperature and pressure — the difference between a wound noticed and a wound found later.

        • Rebuilding cells · Sexual function

          Not searched yet

          Sexual function and fertility, asked about constantly and reported on rarely.

        • Rebuilding cells · Arm and hand

          Not searched yet

          Hand and arm: grip, reach, release. For a cervical injury this is usually the first thing a person asks about.

        • Reconnecting around it · Autonomic regulation

          Not searched yet

          Blood pressure, temperature and autonomic dysreflexia — the outcomes that are dangerous rather than inconvenient.

        • Reconnecting around it · Bladder

          Not searched yet

          Bladder storage, emptying and continence — a daily determinant of health and of whether a person can leave the house.

        • Reconnecting around it · Bowel

          Not searched yet

          Bowel management and continence, which govern how many hours of a day belong to care rather than to living.

        • Reconnecting around it · Everyday independence

          Not searched yet

          Everyday independence: transfers, dressing, self-care — what a person can do without another person in the room.

        • Reconnecting around it · Walking and standing

          Not searched yet

          Standing and walking, with or without help — the outcome most research is measured by, and only one of twelve.

        • Reconnecting around it · Pain

          Not searched yet

          Neuropathic and musculoskeletal pain, including pain that appears after function returns.

        • Reconnecting around it · Sense of body position

          Not searched yet

          Knowing where a limb is without looking at it, which is what makes movement usable rather than merely possible.

        • Reconnecting around it · Breathing

          Not searched yet

          Breathing, cough and ventilator independence, which decide survival after a high cervical injury.

        • Reconnecting around it · Safety and complications

          Not searched yet

          Adverse events, complications and harms — the outcome an intervention is refused for, and the one most easily left out of a summary.

        • Reconnecting around it · Sensation

          Not searched yet

          Feeling touch, temperature and pressure — the difference between a wound noticed and a wound found later.

        • Reconnecting around it · Sexual function

          Not searched yet

          Sexual function and fertility, asked about constantly and reported on rarely.

        • Reconnecting around it · Arm and hand

          Not searched yet

          Hand and arm: grip, reach, release. For a cervical injury this is usually the first thing a person asks about.

        • Regrowing axons · Autonomic regulation

          Not searched yet

          Blood pressure, temperature and autonomic dysreflexia — the outcomes that are dangerous rather than inconvenient.

        • Regrowing axons · Bladder

          Not searched yet

          Bladder storage, emptying and continence — a daily determinant of health and of whether a person can leave the house.

        • Regrowing axons · Bowel

          Not searched yet

          Bowel management and continence, which govern how many hours of a day belong to care rather than to living.

        • Regrowing axons · Everyday independence

          Not searched yet

          Everyday independence: transfers, dressing, self-care — what a person can do without another person in the room.

        • Regrowing axons · Walking and standing

          Not searched yet

          Standing and walking, with or without help — the outcome most research is measured by, and only one of twelve.

        • Regrowing axons · Pain

          Not searched yet

          Neuropathic and musculoskeletal pain, including pain that appears after function returns.

        • Regrowing axons · Sense of body position

          Not searched yet

          Knowing where a limb is without looking at it, which is what makes movement usable rather than merely possible.

        • Regrowing axons · Breathing

          Not searched yet

          Breathing, cough and ventilator independence, which decide survival after a high cervical injury.

        • Regrowing axons · Safety and complications

          Not searched yet

          Adverse events, complications and harms — the outcome an intervention is refused for, and the one most easily left out of a summary.

        • Regrowing axons · Sensation

          Not searched yet

          Feeling touch, temperature and pressure — the difference between a wound noticed and a wound found later.

        • Regrowing axons · Sexual function

          Not searched yet

          Sexual function and fertility, asked about constantly and reported on rarely.

        • Regrowing axons · Arm and hand

          Not searched yet

          Hand and arm: grip, reach, release. For a cervical injury this is usually the first thing a person asks about.

        • Scar and matrix · Autonomic regulation

          Not searched yet

          Blood pressure, temperature and autonomic dysreflexia — the outcomes that are dangerous rather than inconvenient.

        • Scar and matrix · Bladder

          Not searched yet

          Bladder storage, emptying and continence — a daily determinant of health and of whether a person can leave the house.

        • Scar and matrix · Bowel

          Not searched yet

          Bowel management and continence, which govern how many hours of a day belong to care rather than to living.

        • Scar and matrix · Everyday independence

          Not searched yet

          Everyday independence: transfers, dressing, self-care — what a person can do without another person in the room.

        • Scar and matrix · Walking and standing

          Not searched yet

          Standing and walking, with or without help — the outcome most research is measured by, and only one of twelve.

        • Scar and matrix · Pain

          Not searched yet

          Neuropathic and musculoskeletal pain, including pain that appears after function returns.

        • Scar and matrix · Sense of body position

          Not searched yet

          Knowing where a limb is without looking at it, which is what makes movement usable rather than merely possible.

        • Scar and matrix · Breathing

          Not searched yet

          Breathing, cough and ventilator independence, which decide survival after a high cervical injury.

        • Scar and matrix · Safety and complications

          Not searched yet

          Adverse events, complications and harms — the outcome an intervention is refused for, and the one most easily left out of a summary.

        • Scar and matrix · Sensation

          Not searched yet

          Feeling touch, temperature and pressure — the difference between a wound noticed and a wound found later.

        • Scar and matrix · Sexual function

          Not searched yet

          Sexual function and fertility, asked about constantly and reported on rarely.

        • Scar and matrix · Arm and hand

          Not searched yet

          Hand and arm: grip, reach, release. For a cervical injury this is usually the first thing a person asks about.

        • Retraining what remains · Autonomic regulation

          Not searched yet

          Blood pressure, temperature and autonomic dysreflexia — the outcomes that are dangerous rather than inconvenient.

        • Retraining what remains · Bladder

          Not searched yet

          Bladder storage, emptying and continence — a daily determinant of health and of whether a person can leave the house.

        • Retraining what remains · Bowel

          Not searched yet

          Bowel management and continence, which govern how many hours of a day belong to care rather than to living.

        • Retraining what remains · Everyday independence

          Not searched yet

          Everyday independence: transfers, dressing, self-care — what a person can do without another person in the room.

        • Retraining what remains · Walking and standing

          Not searched yet

          Standing and walking, with or without help — the outcome most research is measured by, and only one of twelve.

        • Retraining what remains · Pain

          Not searched yet

          Neuropathic and musculoskeletal pain, including pain that appears after function returns.

        • Retraining what remains · Sense of body position

          Not searched yet

          Knowing where a limb is without looking at it, which is what makes movement usable rather than merely possible.

        • Retraining what remains · Breathing

          Not searched yet

          Breathing, cough and ventilator independence, which decide survival after a high cervical injury.

        • Retraining what remains · Safety and complications

          Not searched yet

          Adverse events, complications and harms — the outcome an intervention is refused for, and the one most easily left out of a summary.

        • Retraining what remains · Sensation

          Not searched yet

          Feeling touch, temperature and pressure — the difference between a wound noticed and a wound found later.

        • Retraining what remains · Sexual function

          Not searched yet

          Sexual function and fertility, asked about constantly and reported on rarely.

        • Retraining what remains · Arm and hand

          Not searched yet

          Hand and arm: grip, reach, release. For a cervical injury this is usually the first thing a person asks about.

        What was searched, and what came back