SCI Regeneration MapWhat the world knows about repairing the injured spinal cord

How the evidence changed its mind

Every verdict this map has held, in the order it held them. The past is never rewritten: a verdict that was reached is kept even after it is replaced.

Published · retrieved · decided are three different dates and are never merged.

DecidedClaimContextWasBecameWhat moved it
2026-08-15 19:34:36.537548+00A fully implanted brain–spine interface maintains reliable calibration and performance over long-term independent use after spinal cord injury.Human · Unknown · ElectrophysiologyNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00A brain–spine interface that links cortical signals to epidural electrical stimulation of the lumbosacral spinal cord restores standing and walking ability after spinal cord injury.Human · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Chondroitinase ABC combined with Schwann cell transplantation improves urinary bladder function after spinal cord injury.Rodent · Chronic · Autonomic functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Chondroitinase ABC combined with Schwann cell transplantation enhances axonal regrowth after spinal cord injury.Rodent · Chronic · Anatomical growthNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Chondroitinase ABC combined with Schwann cell transplantation promotes migration and survival of grafted Schwann cells within the injured spinal cord.Rodent · Chronic · Cell fateNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Neurorehabilitation supported by a brain–spine interface improves neurological recovery after spinal cord injury, including walking ability when the stimulation is switched off.Human · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Cortically commanded control signals enable accurate single-joint and coordinated multi-joint arm movements for target acquisition after spinal cord injury.Human · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Systemic combinatorial blockade of chondroitin sulfate proteoglycan production and the PTPσ receptor improves forelimb and paw motor function after spinal cord injury.Rodent · Chronic · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Ablation of a specific population of excitatory interneurons in the intermediate laminae of the lumbar spinal cord prevents recovery of walking after spinal cord injury.Rodent · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Simultaneous blockade of chondroitin sulfate proteoglycan production and the PTPσ receptor improves fine digit precision movements after spinal cord injury.Rodent · Chronic · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Enzymatic degradation of chondroitin sulfate proteoglycans with Chondroitinase ABC improves motor function after spinal cord injury.Rodent · Chronic · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Implanted conductive carbon nanotube-containing scaffolds improve the electrical conductivity of regenerating tissue at the spinal cord injury site.Rodent · Unknown · Tissue integrityNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Users of a brain–spine interface report natural volitional control over leg movements after spinal cord injury.Human · Unknown · Patient reportedNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Aligned conductive carbon nanotube/GelMA hydrogel fibers combined with electrical stimulation improve motor function recovery after spinal cord injury.Rodent · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Spatiotemporal epidural electrical stimulation of the lumbar spinal cord combined with neurorehabilitation restores walking after spinal cord injury.Rodent · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Aligned conductive carbon nanotube/GelMA hydrogel fibers with electrical stimulation promote neuronal differentiation of neural stem cells.Rodent · Unknown · Cell fateNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Chondroitinase ABC combined with Schwann cell transplantation improves locomotor recovery after spinal cord injury.Rodent · Chronic · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00An intracortical brain-computer interface combined with implanted functional electrical stimulation restores volitional reaching and grasping movements of the paralysed arm after spinal cord injury.Human · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Functional electrical stimulation of upper limb muscles enables performance of functionally meaningful tasks such as drinking and self-feeding after spinal cord injury.Human · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Aligned conductive carbon nanotube/GelMA hydrogel fibers promote axonal regeneration and remyelination after spinal cord injury.Rodent · Unknown · Tissue integrityNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Recovery of walking with epidural electrical stimulation and rehabilitation is accompanied by reduced neuronal activity in the lumbar spinal cord during walking.Rodent · Unknown · ElectrophysiologyNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-15 19:34:36.537548+00Augmenting the activity of a specific population of excitatory interneurons in the intermediate laminae of the lumbar spinal cord promotes recovery of walking after spinal cord injury.Rodent · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00An implanted bioresorbable polymer scaffold improves neurological grade conversion after spinal cord injury.Human · Acute · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00Intrathecal administration of a soluble Nogo receptor decoy protein is well tolerated after spinal cord injury and does not increase the incidence of serious adverse events.Human · Unknown · SafetyNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00The locomotor benefit of chondroitinase ABC after spinal cord injury is not modified by the injury model, the injury severity, or the number of administrations.None · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00Chondroitinase ABC administration improves locomotor recovery after spinal cord injury.None · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00Intrathecal administration of a soluble Nogo receptor decoy protein does not improve upper extremity motor strength or hand prehension function after spinal cord injury.Human · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00An implanted bioresorbable polymer scaffold improves sensory function after spinal cord injury.Human · Acute · Sensory functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00Intrathecal administration of a soluble Nogo receptor decoy protein does not improve self-reported global impression of change or independence in self-care after spinal cord injury.Human · Unknown · Patient reportedNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00The locomotor benefit of chondroitinase ABC after spinal cord injury is not modified by follow-up duration or by the locomotor scoring scale used.None · Unknown · Motor functionNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.
2026-08-14 08:03:50.999403+00Implantation of a bioresorbable polymer scaffold into the injured spinal cord is associated with serious adverse events.Human · Acute · Tissue integrityNo dataNothing has been recorded here yet. This is not a zero.Insufficient dataRecorded before this system tracked causes — not guessed at now.