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Axon-like aligned conductive CNT/GelMA hydrogel fibers combined with electrical stimulation for spinal cord injury recovery.

Source: PubMed · Index · Peer reviewed · real data

Published: 2024-02-22

The injury this work is about

The phase, the band and the outcomes this paper's studies were recorded under, explained in plain words.

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The cord in cross-section at reading size: butterfly-shaped grey matter with its dorsal, lateral and ventral horns; white matter around it; the groove behind and the fissure in front; the sensory rootlets entering behind through their ganglion and the motor rootlets leaving in front, joining as one spinal nerve that then divides. Two arrows: sensation in, movement out.
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Plate 3Atlas of a spinal cord injury3of 19Insidethe cordBackThe cord in cross-section at reading size: butterfly-shaped grey matter with its dorsal, lateral and ventral horns; white matter around it; the groove behind and the fissure in front; the sensory rootlets entering behind through their ganglion and the motor rootlets leaving in front, joining as one spinal nerve that then divides. Two arrows: sensation in, movement out.White matterWhite matterDorsal rootDorsal rootDorsal hornDorsal hornDorsal root ganglionDorsal root ganglionThe cross-sectionThe cross-sectionFrontVentral hornVentral hornVentral rootVentral rootLateral hornLateral hornSpinal nerveSpinal nerveGrey matterGrey matter

What is being changed here, drawn

Inside the cord

The butterfly-shaped centre. Nerve cell bodies sit here: the signal arrives, is processed, and a command leaves.

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  • The meningesThree layers around the cord — dura, arachnoid and pia mater. Between them is fluid that works as a cushion.
  • Cervical regionEight segments, C1–C8. The nerves to the diaphragm, the shoulders and the arms leave from here.
  • Lumbar regionFive segments, L1–L5. The nerves to the hips and legs leave from here.
  • The cross-sectionCut across, the cord shows butterfly-shaped grey matter in the middle and white matter around it. That arrangement is why one injury at one level affects different functions differently.
  • Grey matterThe butterfly-shaped centre. Nerve cell bodies sit here: the signal arrives, is processed, and a command leaves.
  • White matterThe ring around the grey matter. Long fibres in a myelin sheath — the wires the signal travels up and down.
  • Ventral hornThe front part of the butterfly. The motor neurons that drive muscles directly sit here.
  • Ventral rootThe bundle of fibres leaving the cord in front, carrying motor commands out to the muscles.

Identifiers

  • DOI: 10.1016/j.bioactmat.2024.01.021
  • PubMed ID: 38414842
  • PMCID: PMC10897856

Claims this paper bears on

  • Supports — Aligned conductive carbon nanotube/GelMA hydrogel fibers promote axonal regeneration and remyelination after spinal cord injury.
  • Supports — Aligned conductive carbon nanotube/GelMA hydrogel fibers with electrical stimulation promote neuronal differentiation of neural stem cells.
  • Supports — Aligned conductive carbon nanotube/GelMA hydrogel fibers combined with electrical stimulation improve motor function recovery after spinal cord injury.
  • Supports — Implanted conductive carbon nanotube-containing scaffolds improve the electrical conductivity of regenerating tissue at the spinal cord injury site.

Results extracted

ResultLocation in the sourceQuotation
Anatomical growth · ExploratoryabstractQuotation withheld: the right to display this text is not established.
Cell fate · ExploratoryabstractQuotation withheld: the right to display this text is not established.
Tissue integrity · ExploratoryabstractQuotation withheld: the right to display this text is not established.
Electrophysiology · ExploratoryabstractQuotation withheld: the right to display this text is not established.
Motor function · ExploratoryabstractQuotation withheld: the right to display this text is not established.
Anatomical growth · ExploratoryabstractQuotation withheld: the right to display this text is not established.
Cell fate · ExploratoryabstractQuotation withheld: the right to display this text is not established.
Tissue integrity · ExploratoryabstractQuotation withheld: the right to display this text is not established.

Study

  • 38414842/abstract У пробірці
  • 38414842/abstract У пробірці
  • 38414842/abstract rodent

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