Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury.

Source: PubMed · Index · Peer reviewed · real data

Published: 2025-05-01

The injury this work is about

The phase, the band and the outcomes this paper's studies were recorded under, explained in plain words.

The cord in cross-section at reading size: butterfly-shaped grey matter with its dorsal, lateral and ventral horns; white matter around it; the groove behind and the fissure in front; the sensory rootlets entering behind through their ganglion and the motor rootlets leaving in front, joining as one spinal nerve that then divides. Two arrows: sensation in, movement out.

What is being changed here, drawn

Inside the cord

The butterfly-shaped centre. Nerve cell bodies sit here: the signal arrives, is processed, and a command leaves.

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Cervical regionEight segments, C1–C8. The nerves to the diaphragm, the shoulders and the arms leave from here.
Lumbar regionFive segments, L1–L5. The nerves to the hips and legs leave from here.
Grey matterThe butterfly-shaped centre. Nerve cell bodies sit here: the signal arrives, is processed, and a command leaves.
White matterThe ring around the grey matter. Long fibres in a myelin sheath — the wires the signal travels up and down.
Ventral hornThe front part of the butterfly. The motor neurons that drive muscles directly sit here.
Ventral rootThe bundle of fibres leaving the cord in front, carrying motor commands out to the muscles.
Corticospinal tractA descending path from the motor cortex to the motor neurons. It carries voluntary movement and crosses to the other side in the brainstem.
Motor signsWeakness, loss of voluntary movement, a change in tone. What exactly, and where, depends on the level and the completeness.

Identifiers

DOI: 10.4103/NRR.NRR-D-23-01338
PubMed ID: 39075913
PMCID: PMC11624882

Claims this paper bears on

Supports — Chondroitinase ABC combined with Schwann cell transplantation improves locomotor recovery after spinal cord injury.
Supports — Chondroitinase ABC combined with Schwann cell transplantation promotes migration and survival of grafted Schwann cells within the injured spinal cord.
Supports — Chondroitinase ABC combined with Schwann cell transplantation enhances axonal regrowth after spinal cord injury.
Supports — Chondroitinase ABC combined with Schwann cell transplantation improves urinary bladder function after spinal cord injury.

Results extracted

Result	Location in the source	Quotation
Anatomical growth · Exploratory	abstract	Quotation withheld: the right to display this text is not established.
Motor function · Exploratory	abstract	Quotation withheld: the right to display this text is not established.
Autonomic function · Exploratory	abstract	Quotation withheld: the right to display this text is not established.
Cell fate · Exploratory	abstract	Quotation withheld: the right to display this text is not established.
Cell fate · Exploratory	abstract	Quotation withheld: the right to display this text is not established.

Study

39075913/abstract rodent
39075913/abstract rodent

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