A subject this map covers
Macrophage therapy and polarisation
Part of: Inflammation and immune response
What belongs here
Delivering or reprogramming macrophages to change the character of inflammation at the injury.
What does not belong here, however close it looks
Describing what macrophages do without intervening is mechanism, not therapy; such a record stays in the parent concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 265 records · 1967–2026
- Indexed as work in animals: 781 records · 1966–2026
- Indexed as laboratory work: 41 records · 1988–2026
- The source has not said who or what was studied: 211 records · 1999–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1298 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury. — PubMed · 2024 · Journal Article
- Local delivery of AdipoRon from self-assembled microparticles to inhibit myelin lipid uptake and to promote lipid efflux from rat macrophages. — PubMed · 2024 · Journal Article
- Nitric oxide-induced lipophagic defects contribute to testosterone deficiency in rats with spinal cord injury. — PubMed · 2024 · Journal Article
- The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol. — PubMed · 2024 · Journal Article
- Hmox1 is Identified as a Ferroptosis Hub Gene and Associated with the M1 Type Microglia/Macrophage Polarization in Spinal Cord Injury: Bioinformatics and Experimental Validation. — PubMed · 2023 · Journal Article
- Knowledge Mapping of Macrophage in Spinal Cord Injury: A Bibliometric Analysis. — PubMed · 2023 · Journal Article
- The role and mechanisms of mesenchymal stem cells regulating macrophage plasticity in spinal cord injury. — PubMed · 2023 · Journal Article
- Supramolecular assemblies with spatio-temporal sequential drug delivery capability treat spinal cord injury via neuroprotection and immunoregulation. — PubMed · 2023 · Journal Article
- Transplantation of Wnt4-modified neural stem cells mediate M2 polarization to improve inflammatory micro-environment of spinal cord injury. — PubMed · 2023 · Journal Article
- [Research progress of acupuncture-moxibustion in treatment of spinal cord injury through mediating inflammatory reaction]. — PubMed · 2023 · English Abstract
- Enzyme-Mediated Nerve Growth Factor Release from Nanofibers Using Gelatin Microspheres. — PubMed · 2023 · Journal Article
- Human mesenchymal stem-derived extracellular vesicles improve body growth and motor function following severe spinal cord injury in rat. — PubMed · 2023 · Journal Article
- Role of regulatory T cells in spinal cord injury. — PubMed · 2023 · Journal Article
- The Role of Tumor Necrosis Factor Following Spinal Cord Injury: A Systematic Review. — PubMed · 2023 · Systematic Review
- Macrophage-Neuroglia Interactions in Promoting Neuronal Regeneration in Zebrafish. — PubMed · 2023 · Journal Article
- Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases. — PubMed · 2023 · Journal Article
- Myelin Debris Impairs Tight Junctions and Promotes the Migration of Microvascular Endothelial Cells in the Injured Spinal Cord. — PubMed · 2023 · Journal Article
- Comprehensive landscape of immune-based classifier related to early diagnosis and macrophage M1 in spinal cord injury. — PubMed · 2023 · Journal Article
- The role of immune cells and associated immunological factors in the immune response to spinal cord injury. — PubMed · 2023 · Journal Article
- Advanced Therapies for Traumatic Central Nervous System Injury: Delivery Strategy Reinforced Efficient Microglial Manipulation. — PubMed · 2023 · Journal Article
- Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury. — PubMed · 2022 · Systematic Review
- Macrophage Extracellular Traps Exacerbate Secondary Spinal Cord Injury by Modulating Macrophage/Microglia Polarization via LL37/P2X7R/NF-κB Signaling Pathway. — PubMed · 2022 · Journal Article
- More Attention on Segments Remote from the Primary Spinal Cord Lesion Site. — PubMed · 2022 · Journal Article
- Nanogel-mediated delivery of oncomodulin secreted from regeneration-associated macrophages promotes sensory axon regeneration in the spinal cord. — PubMed · 2022 · Journal Article
- Emerging Roles of Microglia Depletion in the Treatment of Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Spinal cord injury in mice affects central and peripheral pathology in a severity-dependent manner. — PubMed · 2022 · Journal Article
- Levetiracetam Attenuates the Spinal Cord Injury Induced by Acute Trauma via Suppressing the Expression of Perforin. — PubMed · 2022 · Journal Article The source marks this record as retracted.
- Investigating Mechanisms of Subcutaneous Preconditioning Incubation for Neural Stem Cell Embedded Hydrogels. — PubMed · 2022 · Journal Article
- D-4F, an apolipoprotein A-I mimetic, promotes the clearance of myelin debris and the reduction of foamy macrophages after spinal cord injury. — PubMed · 2022 · Journal Article
- Macrophage-based delivery of interleukin-13 improves functional and histopathological outcomes following spinal cord injury. — PubMed · 2022 · Journal Article
- Cell-Free Extracts from Human Fat Tissue with a Hyaluronan-Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization. — PubMed · 2022 · Journal Article
- [Research progress of Notch signaling pathway in spinal cord injury]. — PubMed · 2022 · Journal Article
- Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury. — PubMed · 2022 · Journal Article
- Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow-derived macrophages under inflammatory stress. — PubMed · 2022 · Journal Article
- Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar. — PubMed · 2021 · Journal Article
- Macrophage phagocytosis after spinal cord injury: when friends become foes. — PubMed · 2021 · Journal Article
- Target Sestrin2 to Rescue the Damaged Organ: Mechanistic Insight into Its Function. — PubMed · 2021 · Journal Article
- Microglia contributes to remyelination in cerebral but not spinal cord ischemia. — PubMed · 2021 · Journal Article
- Protective Effects of Estrogen via Nanoparticle Delivery to Attenuate Myelin Loss and Neuronal Death after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Role of Aldynoglia Cells in Neuroinflammatory and Neuroimmune Responses after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Anti-Inflammatory Nanotherapeutics by Targeting Matrix Metalloproteinases for Immunotherapy of Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Macrophage-mediated degradable gelatin-coated mesoporous silica nanoparticles carrying pirfenidone for the treatment of rat spinal cord injury. — PubMed · 2021 · Journal Article
- Therapy of spinal cord injury by zinc modified gold nanoclusters via immune-suppressing strategies. — PubMed · 2021 · Journal Article
- Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury. — PubMed · 2021 · Journal Article
- TNF promotes M1 polarization through mitochondrial metabolism in injured spinal cord. — PubMed · 2021 · Journal Article
- Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss. — PubMed · 2021 · Journal Article
- Macrophage migration inhibitory factor as a therapeutic target after traumatic spinal cord injury: a systematic review. — PubMed · 2021 · Journal Article
- Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury. — PubMed · 2021 · Journal Article
- The effects of myelin on macrophage activation are phenotypic specific via cPLA(2) in the context of spinal cord injury inflammation. — PubMed · 2021 · Journal Article
- Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity. — PubMed · 2021 · Journal Article
- Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury. — PubMed · 2021 · Journal Article
- Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury. — PubMed · 2021 · Journal Article
- The Pathogenesis of Neurotrauma Indicates Targets for Neuroprotective Therapies. — PubMed · 2021 · Journal Article
- TGFβ3 is neuroprotective and alleviates the neurotoxic response induced by aligned poly-l-lactic acid fibers on naïve and activated primary astrocytes. — PubMed · 2020 · Journal Article
- Spatio-temporal and Cellular Expression Patterns of PTK7 in the Healthy and Traumatically Injured Rat and Human Spinal Cord. — PubMed · 2020 · Journal Article
- Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma. — PubMed · 2020 · Journal Article
- Targeted Delivery of Mesenchymal Stem Cell-Derived Nanovesicles for Spinal Cord Injury Treatment. — PubMed · 2020 · Journal Article
- Overexpression of Rictor in the injured spinal cord promotes functional recovery in a rat model of spinal cord injury. — PubMed · 2020 · Journal Article
- Prolonged inflammation leads to ongoing damage after spinal cord injury. — PubMed · 2020 · Journal Article
- The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury. — PubMed · 2020 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1037078 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 4 · this programme has 1301 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("macrophage" OR "macrophage polarization" OR "autologous incubated macrophage") - Crossref
spinal cord injury macrophage macrophage polarization - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Macrophages"[MeSH Terms] OR "macrophage"[Title/Abstract] OR "macrophage polarization"[Title/Abstract] OR "autologous incubated macrophage"[Title/Abstract])