A subject this map covers
Macrophage therapy and polarisation
Part of: Inflammation and immune response
What belongs here
Delivering or reprogramming macrophages to change the character of inflammation at the injury.
What does not belong here, however close it looks
Describing what macrophages do without intervening is mechanism, not therapy; such a record stays in the parent concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 265 records · 1967–2026
- Indexed as work in animals: 781 records · 1966–2026
- Indexed as laboratory work: 41 records · 1988–2026
- The source has not said who or what was studied: 211 records · 1999–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1298 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- A supramolecular MgTA@MnO₂ nanozyme platform supports human spinal cord organoid structural integration and locomotor recovery via microenvironmental reprogramming. — PubMed · 2026 · Journal Article
- Mesenchymal stem cell-derived small extracellular vesicles in spinal cord injury: From molecular repair mechanisms to standardized translational development. — PubMed · 2026 · Journal Article
- Exosome-mediated macrophage polarization: advances in immunotherapeutic paradigms and mechanisms in skeletal system diseases. — PubMed · 2026 · Journal Article
- Research Progress on Regulating Neuroinflammation After Spinal Cord Injury by Targeting the cGAS-STING Pathway. — PubMed · 2026 · Journal Article
- Therapeutic Window for Intravenous Human Muse Cell Administration in Mouse Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Harnessing wireless electrical stimulation and silk-based conductive hydrogels to boost iPSC-derived astrocytes neuroprotection and guide macrophage polarisation in vitro for spinal cord repair. — PubMed · 2026 · Journal Article
- Liposomal multimodal theranostics for bone disorders: from rational responsive delivery and biomimetic strategies to clinical translation. — PubMed · 2026 · Journal Article
- Upregulation of the Mitophagy-Related Gene EXOSC4 Is Associated with Immune Dysregulation in Spinal Cord Injury. — PubMed · 2026 · Journal Article
- The immune dysregulation landscape and dynamic regulation of competing endogenous RNAs in spinal cord injury. — PubMed · 2026 · Journal Article
- Coacervates Made of Elastin-Like Polypeptides Fused with Melanocyte-Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord-Injured Mice. — PubMed · 2026 · Journal Article
- Histone H3K9 lactylation activates the TXNIP/NLRP3 pathway to drive macrophage inflammation after spinal cord injury. — PubMed · 2026 · Journal Article
- Machine learning-based identification of potential diagnostic signatures in spinal cord injury. — PubMed · 2026 · Journal Article
- Phase-dependent efficacy of intravenous amniotic mesenchymal stem cells in a rat spinal cord injury model. — PubMed · 2026 · Journal Article
- The Pivotal Roles of Macrophages and Microglia in Mesenchymal Stromal/Stem Cell-Derived Small Extracellular Vesicle-Mediated Tissue Repair After Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Enhanced MIF/CD74 axis activity shapes B cell functioning following traumatic spinal cord injury. — PubMed · 2026 · Journal Article
- Many but not all pathogen-associated molecular patterns aggravate neurogenic heterotopic ossification after spinal cord injury. — PubMed · 2026 · Journal Article
- Continuous intravenous infusion of human mesenchymal stromal cell-derived small extracellular vesicles in spinal cord injured rat modulates extracellular matrix and has greater therapeutic efficacy than multiple single injections. — PubMed · 2026 · Journal Article
- Injectable hydrogel-based localized delivery of IDO-galectin-3 mitigates neuroinflammation and promotes neuronal sparing after spinal cord contusion in rats. — PubMed · 2026 · Journal Article
- Decoding TREM2 Signaling Pathways: Linking Macrophage Glycolysis to Inflammatory Diseases in the CNS. — PubMed · 2026 · Journal Article
- RPS3-Enriched Extracellular Vesicles Mediate Liver-Spinal Cord Inter-Organ Communication. — PubMed · 2026 · Journal Article
- Neural Stem Cells and Inflammation Modulation in Preclinical Spinal Cord Injury: A Systematic Review. — PubMed · 2026 · Journal Article
- Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats. — PubMed · 2026 · Journal Article
- Tumor-associated macrophages enhance peripheral nerve tumor infiltration and spinal cord repair. — PubMed · 2026 · Journal Article
- Beyond exercise and appetite: The expanding biology and therapeutic potential of N-lactoyl-phenylalanine. — PubMed · 2026 · Journal Article
- Camouflaged nanorobots target and regulate macrophage subcellular organelle crosstalk patterns to promote neural regeneration. — PubMed · 2026 · Journal Article
- Host immune determinants of stromal vascular fraction graft survival: Toward a concept of SVF therapy resistance - A systematic narrative review. — PubMed · 2026 · Journal Article
- Identification and Verification of Mitochondria-Related Diagnostic Markers of Spinal Cord Injury by WGCNA and Machine Learning. — PubMed · 2026 · Journal Article
- The forgotten inflammasomes: AIM2, NLRP1, and NLRC4 in spinal cord injury and neuroinflammation. — PubMed · 2025 · Journal Article
- The role of polarization dynamics in macrophages and microglia on the inflammatory microenvironment of spinal cord injury. — PubMed · 2025 · Journal Article
- From Single-Cell Atlas to Functional Validation: Critical Next Steps for Understanding Tip Cell-Mediated Communication in the Injured Spinal Cord. — PubMed · 2025 · Letter
- Is TREM2 a Stretch: Implications of TREM2 Along Spinal Cord Circuits in Health, Aging, Injury, and Disease. — PubMed · 2025 · Journal Article
- How Advanced Are Exosomes as Cell-Free Therapeutics for Spinal Cord Injury? — PubMed · 2025 · Journal Article
- Evolving insights on the role of microglia in neuroinflammation, plasticity, and regeneration of the injured spinal cord. — PubMed · 2025 · Journal Article
- Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8(+) T lymphocytes and aggravates spinal cord injury. — PubMed · 2025 · Journal Article
- Macrophage polarization-related gene SOAT1 is involved in inflammatory response and functional recovery after spinal cord injury. — PubMed · 2025 · Journal Article
- Extracellular Vesicle (EV) Targeted Cells Release Secondary Effector EVs: Indication of How To Account for Histocompatibility and Disease Specificity of EV Treatments. — PubMed · 2025 · Journal Article
- Metabolic Reprogramming in Spinal Cord Injury and Analysis of Potential Therapeutic Targets. — PubMed · 2025 · Journal Article
- Nanoparticle delivery of CD68 siRNA inhibits neuroimmune responses by inhibiting activation of M1 macrophages. — PubMed · 2025 · Journal Article
- Flavonoids in the regulation of microglial-mediated neuroinflammation; focus on fisetin, rutin, and quercetin. — PubMed · 2025 · Journal Article
- Human Amniotic Epithelial Stem Cells Promote Functional Recovery After Spinal Cord Injury In Rats By Regulating The Polarization Of Macrophages. — PubMed · 2025 · Journal Article
- IL-4-primed human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate recovery in spinal cord injury via the miR-21-5p/PDCD4-mediated shifting of macrophage M1/M2 polarization. — PubMed · 2025 · Journal Article
- Macrophages dying from ferroptosis promote microglia-mediated inflammatory responses during spinal cord injury. — PubMed · 2024 · Journal Article
- Unveiling vital biomarkers and immune infiltration profiles in endoplasmic reticulum stress following spinal cord injury. — PubMed · 2024 · Journal Article
- Pharmacological Network Analysis of the Functions and Mechanism of Quercetin From Jisuikang (JSK) in Spinal Cord Injury (SCI). — PubMed · 2024 · Journal Article
- The macrophage migration inhibitory factor/CD74 axis in traumatic spinal cord injury: lessons learned from animal and human studies. — PubMed · 2024 · Journal Article
- Extracellular vesicles loaded with ApoB-100 protein affect the occurrence of coronary heart disease in patients after injury of spinal cord. — PubMed · 2024 · Journal Article The source marks this record as retracted.
- The involvement and significance of M2 macrophages in neuropathic pain following spinal cord injury: a systematic review. — PubMed · 2024 · Journal Article
- Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway. — PubMed · 2024 · Journal Article
- S100A9 Induces Macrophage M2 Polarization and Immunomodulatory Role in the Lesion Site After Spinal Cord Injury in Rats. — PubMed · 2024 · Journal Article
- PDE4D: A Multipurpose Pharmacological Target. — PubMed · 2024 · Journal Article
- Re-analysis of single-cell RNA-seq data reveals the origin and roles of cycling myeloid cells. — PubMed · 2024 · Journal Article
- Recombinant fibroblast growth factor 4 ameliorates axonal regeneration and functional recovery in acute spinal cord injury through altering microglia/macrophage phenotype. — PubMed · 2024 · Journal Article
- Immunotherapy of M2 macrophage derived from exosome-based nanoparticles for spinal cord injury. — PubMed · 2024 · Journal Article
- Human Adipose Tissue Lysate-Based Hydrogel for Lasting Immunomodulation to Effectively Improve Spinal Cord Injury Repair. — PubMed · 2024 · Journal Article
- Modulation of Inflammatory Responses to Enhance Nerve Recovery after Spinal Cord Injury. — PubMed · 2024 · Editorial
- Modified ZIF-8 Nanoparticles for Targeted Metabolic Treatment of Acute Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Injectable Hydrogel To Deliver Bone Mesenchymal Stem Cells Preloaded with Azithromycin To Promote Spinal Cord Repair. — PubMed · 2024 · Journal Article
- BM-MSC-Loaded Graphene-Collagen Cryogels Ameliorate Neuroinflammation in a Rat Spinal Cord Injury Model. — PubMed · 2024 · Journal Article
- The role of foam cells in spinal cord injury: challenges and opportunities for intervention. — PubMed · 2024 · Journal Article
- BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury. — PubMed · 2024 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1037078 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 4 · this programme has 1301 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("macrophage" OR "macrophage polarization" OR "autologous incubated macrophage") - Crossref
spinal cord injury macrophage macrophage polarization - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Macrophages"[MeSH Terms] OR "macrophage"[Title/Abstract] OR "macrophage polarization"[Title/Abstract] OR "autologous incubated macrophage"[Title/Abstract])