A subject this map covers
Intrinsic growth programme
Part of: Axon growth and regeneration
What belongs here
Intervening in the neuron’s own genes and signals that decide whether it can grow at all.
What does not belong here, however close it looks
External obstacles to growth — scar and myelin — have their own concepts.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 35 records · 2003–2025
- Indexed as work in animals: 88 records · 1985–2026
- Indexed as laboratory work: 2 records · 2017–2019
- The source has not said who or what was studied: 68 records · 1976–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
193 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- MiR-212-3p improves rat functional recovery and inhibits neurocyte apoptosis in spinal cord injury models via PTEN downregulation-mediated activation of AKT/mTOR pathway. — PubMed · 2021 · Journal Article
- MicroRNAs 21 and 199a-3p Regulate Axon Growth Potential through Modulation of Pten and mTor mRNAs. — PubMed · 2021 · Journal Article
- Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA‑21‑mediated PTEN/AKT/mTOR pathway. — PubMed · 2021 · Journal Article
- Activation of Neuroprotective Microglia and Astrocytes at the Lesion Site and in the Adjacent Segments Is Crucial for Spontaneous Locomotor Recovery after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Combining task-based rehabilitative training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice. — PubMed · 2021 · Journal Article
- Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury. — PubMed · 2021 · Journal Article
- PTEN Blocking Stimulates Corticospinal and Raphespinal Axonal Regeneration and Promotes Functional Recovery After Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Role of Myc Proto-Oncogene as a Transcriptional Hub to Regulate the Expression of Regeneration-Associated Genes following Preconditioning Peripheral Nerve Injury. — PubMed · 2021 · Journal Article
- MiR-19b-3p accelerates bone loss after spinal cord injury by suppressing osteogenesis via regulating PTEN/Akt/mTOR signalling. — PubMed · 2021 · Journal Article
- Protocatechuic aldehyde mitigates hydrogen peroxide-triggered PC12 cell damage by down-regulating MEG3. — PubMed · 2020 · Journal Article
- PTEN-silencing combined with ChABC-overexpression in adipose-derived stem cells promotes functional recovery of spinal cord injury in rats. — PubMed · 2020 · Journal Article
- Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury. — PubMed · 2020 · Journal Article
- HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI. — PubMed · 2020 · Journal Article
- MicroRNA-92a-3p enhances functional recovery and suppresses apoptosis after spinal cord injury via targeting phosphatase and tensin homolog. — PubMed · 2020 · Journal Article
- LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3. — PubMed · 2020 · Journal Article
- Bisperoxovanadium induces M2-type macrophages and promotes functional recovery after spinal cord injury. — PubMed · 2019 · Journal Article
- Bisperoxovanadium Mediates Neuronal Protection through Inhibition of PTEN and Activation of PI3K/AKT-mTOR Signaling after Traumatic Spinal Injuries. — PubMed · 2019 · Journal Article
- An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle. — PubMed · 2019 · Journal Article
- Required growth facilitators propel axon regeneration across complete spinal cord injury. — PubMed · 2018 · Journal Article
- RhoA activation in axotomy-induced neuronal death. — PubMed · 2018 · Journal Article
- Systemic administration of epothilone D improves functional recovery of walking after rat spinal cord contusion injury. — PubMed · 2018 · Journal Article
- PTEN expression in astrocytic processes after spinal cord injury. — PubMed · 2018 · Journal Article
- Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. — PubMed · 2018 · Journal Article
- A Small Organic Compound Mimicking the L1 Cell Adhesion Molecule Promotes Functional Recovery after Spinal Cord Injury in Zebrafish. — PubMed · 2018 · Journal Article
- miR-181d-5p promotes neurite outgrowth in PC12 Cells via PI3K/Akt pathway. — PubMed · 2017 · Journal Article
- MicroRNA‑21 promotes neurite outgrowth by regulating PDCD4 in a rat model of spinal cord injury. — PubMed · 2017 · Journal Article
- Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury. — PubMed · 2017 · Journal Article
- MicroRNA-494 improves functional recovery and inhibits apoptosis by modulating PTEN/AKT/mTOR pathway in rats after spinal cord injury. — PubMed · 2017 · Journal Article
- RETRACTED: Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury. — PubMed · 2017 · Journal Article The source marks this record as retracted.
- MiR-17 targets PTEN and facilitates glial scar formation after spinal cord injuries via the PI3K/Akt/mTOR pathway. — PubMed · 2017 · Journal Article
- Tetramethylpyrazine enhances functional recovery after contusion spinal cord injury by modulation of MicroRNA-21, FasL, PDCD4 and PTEN expression. — PubMed · 2016 · Journal Article
- Long-term consequences of conditional genetic deletion of PTEN in the sensorimotor cortex of neonatal mice. — PubMed · 2016 · Journal Article
- STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. — PubMed · 2016 · Journal Article
- Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System. — PubMed · 2016 · Journal Article
- Nonspecific labeling limits the utility of Cre-Lox bred CST-YFP mice for studies of corticospinal tract regeneration. — PubMed · 2015 · Journal Article
- Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration. — PubMed · 2015 · Journal Article
- Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3. — PubMed · 2015 · Journal Article
- Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3) Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury. — PubMed · 2015 · Journal Article
- A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury. — PubMed · 2015 · Journal Article
- shRNA against PTEN promotes neurite outgrowth of cortical neurons and functional recovery in spinal cord contusion rats. — PubMed · 2015 · Journal Article
- Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice. — PubMed · 2015 · Journal Article
- SOCS3: a common target for neuronal protection and axon regeneration after spinal cord injury. — PubMed · 2015 · Journal Article
- AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury. — PubMed · 2014 · Journal Article
- PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury. — PubMed · 2014 · Journal Article
- Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish. — PubMed · 2014 · Journal Article
- Spinal cord regeneration. — PubMed · 2014 · Journal Article
- Intermittent hypoxia training after C2 hemisection modifies the expression of PTEN and mTOR. — PubMed · 2013 · Journal Article
- Combining neurotrophin-transduced schwann cells and rolipram to promote functional recovery from subacute spinal cord injury. — PubMed · 2013 · Journal Article
- Alterations in mouse hypothalamic adipokine gene expression and leptin signaling following chronic spinal cord injury and with advanced age. — PubMed · 2012 · Journal Article
- Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. — PubMed · 2012 · Journal Article
- Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. — PubMed · 2012 · Journal Article
- Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury. — PubMed · 2011 · Journal Article
- PTEN deletion enhances the regenerative ability of adult corticospinal neurons. — PubMed · 2010 · Journal Article
- Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-gamma. — PubMed · 2009 · Journal Article
- Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS. — PubMed · 2008 · Journal Article
- GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord. — PubMed · 2007 · Journal Article
- Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state. — PubMed · 2007 · Journal Article
- Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition. — PubMed · 2007 · Comparative Study
- Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. — PubMed · 2006 · Journal Article
- Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. — PubMed · 2006 · Comparative Study
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 2724720 · this programme has 49 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it has nothing | asked on 2026-10-12 | the source found 0 · this programme has 153 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("PTEN deletion" OR "intrinsic growth capacity" OR "SOCS3") - Crossref
spinal cord injury PTEN deletion intrinsic growth capacity - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("PTEN Phosphohydrolase"[MeSH Terms] OR "PTEN deletion"[Title/Abstract] OR "intrinsic growth capacity"[Title/Abstract] OR "SOCS3"[Title/Abstract])