A subject this map covers
Intrinsic growth programme
Part of: Axon growth and regeneration
What belongs here
Intervening in the neuron’s own genes and signals that decide whether it can grow at all.
What does not belong here, however close it looks
External obstacles to growth — scar and myelin — have their own concepts.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 35 records · 2003–2025
- Indexed as work in animals: 88 records · 1985–2026
- Indexed as laboratory work: 2 records · 2017–2019
- The source has not said who or what was studied: 68 records · 1976–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
193 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Unraveling the role of MAG, PTEN, and NOTCH1 in axonal regeneration: a network analysis and molecular dynamics study of siRNA/drugs/nanocarriers interactions. — PubMed · 2025 · Journal Article
- Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review. — PubMed · 2024 · Journal Article
- Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration. — PubMed · 2023 · Journal Article
- PTEN knockout using retrogradely transported AAVs transiently restores locomotor abilities in both acute and chronic spinal cord injury. — PubMed · 2023 · Journal Article
- Extracellular vesicles from human umbilical cord mesenchymal stem cells reduce lipopolysaccharide-induced spinal cord injury neuronal apoptosis by mediating miR-29b-3p/PTEN. — PubMed · 2022 · Journal Article
- Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury. — PubMed · 2022 · Journal Article
- Exosomes Derived from Nerve Stem Cells Loaded with FTY720 Promote the Recovery after Spinal Cord Injury in Rats by PTEN/AKT Signal Pathway. — PubMed · 2021 · Journal Article
- Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice. — PubMed · 2021 · Journal Article
- Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury. — PubMed · 2020 · Journal Article The source marks this record as retracted.
- Growth-Promoting Treatment Screening for Corticospinal Neurons in Mouse and Man. — PubMed · 2020 · Journal Article
- Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. — PubMed · 2020 · Journal Article
- Targeting chondroitinase ABC to axons enhances the ability of chondroitinase to promote neurite outgrowth and sprouting. — PubMed · 2020 · Journal Article
- MiR-21 derived from the exosomes of MSCs regulates the death and differentiation of neurons in patients with spinal cord injury. — PubMed · 2019 · Journal Article
- MiR-92b-3p promotes neurite growth and functional recovery via the PTEN/AKT pathway in acute spinal cord injury. — PubMed · 2019 · Journal Article
- Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury. — PubMed · 2019 · Journal Article
- miR-21 and miR-19b delivered by hMSC-derived EVs regulate the apoptosis and differentiation of neurons in patients with spinal cord injury. — PubMed · 2019 · Journal Article
- Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. — PubMed · 2019 · Journal Article
- PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo. — PubMed · 2018 · Journal Article
- Platelet-Rich Plasma Injection in Burn Scar Areas Alleviates Neuropathic Scar Pain. — PubMed · 2018 · Journal Article
- Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury. — PubMed · 2017 · Journal Article
- Reaching the brain: Advances in optic nerve regeneration. — PubMed · 2017 · Journal Article
- Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury. — PubMed · 2016 · Journal Article
- The role of the PI3K/Akt/mTOR pathway in glial scar formation following spinal cord injury. — PubMed · 2016 · Journal Article
- Expression of suppressor of cytokine signaling-3 (SOCS3) and its role in neuronal death after complete spinal cord injury. — PubMed · 2014 · Journal Article
- Selective expression of CSPG receptors PTPσ and LAR in poorly regenerating reticulospinal neurons of lamprey. — PubMed · 2014 · Journal Article
- The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury. — PubMed · 2014 · Journal Article
- Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury. — PubMed · 2013 · Journal Article
- Scar-mediated inhibition and CSPG receptors in the CNS. — PubMed · 2012 · Journal Article
- Dependence of regenerated sensory axons on continuous neurotrophin-3 delivery. — PubMed · 2012 · Journal Article
- SOCS1 and SOCS3 in the control of CNS immunity. — PubMed · 2009 · Journal Article
- Pharmacological approaches to induce neuroregeneration in spinal cord injury: an overview. — PubMed · 2009 · Journal Article
- Axon regeneration in the peripheral and central nervous systems. — PubMed · 2009 · Journal Article
- Neuroscience. Overcoming inhibitions. — PubMed · 2008 · Journal Article
- Association of multiple vertebral hemangiomas and severe paraparesis in a patient with a PTEN hamartoma tumor syndrome. Case report. — PubMed · 2007 · Case Reports
- Gene expression changes after focal stroke, traumatic brain and spinal cord injuries. — PubMed · 2003 · Journal Article
Indexed as work in animals
- Proteomics reveal PTEN as a critical mediator of sustained mitochondrial dysfunction during chronic spinal cord injury. — PubMed · 2026 · Journal Article
- miR-19a-3p and miR-19b-3p Promote Microglia Activation Associated With Neuroinflammation. — PubMed · 2026 · Journal Article
- Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after spinal cord injury. — PubMed · 2026 · Journal Article
- Hyaluronic Acid Hydrogel-Mediated Delivery of MSC-Derived Exo-FGF21 Promotes Spinal Cord Injury Repair via STAT3/SOCS3 Signaling. — PubMed · 2026 · Journal Article
- NanoScript-Enabled Nonviral Transient Repression of Phosphatase and Tensin Homolog for Axonal Regeneration and Central Nervous System Injury Repair. — PubMed · 2026 · Journal Article
- Bone mesenchymal stem cells attenuate axonopathy in spinal cord of rats exposed to 2,5-hexanedione via NGF-dependent and -independent pathways. — PubMed · 2026 · Journal Article
- Columbianadin improves M1 polarization of microglia after spinal cord injury by stabilizing PTEN and inhibiting the PI3K/AKT pathway. — PubMed · 2026 · Journal Article
- Serotonergic System-Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy. — PubMed · 2026 · Journal Article
- Bilirubin Alleviates Spinal Cord Injury by Enhancing SOCS3-Mediated Anti-Inflammatory Effects via Gas6-Axl Signaling. — PubMed · 2025 · Journal Article
- Early Pro- and Anti-Inflammatory Immune Response Induced by Probiotic Treatment After Th9 Compression: The Interplay Between Spinal Cord and Jejunum. — PubMed · 2025 · Journal Article
- Modulation of Extrinsic and Intrinsic Signaling Together with Neuronal Activation Enhances Forelimb Motor Recovery after Cervical Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Electroacupuncture stimulation inhibited astrogliosis and microglia polarisation to alleviate spinal cord injury via Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. — PubMed · 2025 · Journal Article
- Nonresolving Neuroinflammation Regulates Axon Regeneration in Chronic Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Molecular signaling predicts corticospinal axon growth state and muscle response plasticity induced by neuromodulation. — PubMed · 2024 · Journal Article
- LncRNA TSIX knockdown restores spinal cord injury repair through miR-30a/SOCS3 axis. — PubMed · 2024 · Journal Article
- PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury. — PubMed · 2024 · Journal Article
- Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. — PubMed · 2023 · Journal Article
- Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury. — PubMed · 2023 · Journal Article
- MiR-155-5p Aggravated Astrocyte Activation and Glial Scarring in a Spinal Cord Injury Model by Inhibiting Ndfip1 Expression and PTEN Nuclear Translocation. — PubMed · 2023 · Journal Article
- Effects of task-based rehabilitative training combined with PTEN/SOCS3 coinhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice. — PubMed · 2023 · Journal Article
- Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury. — PubMed · 2023 · Journal Article
- A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord. — PubMed · 2022 · Journal Article
- Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury. — PubMed · 2022 · Journal Article
- Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Exosomes-mediated phenotypic switch of macrophages in the immune microenvironment after spinal cord injury. — PubMed · 2021 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 2724720 · this programme has 49 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it has nothing | asked on 2026-10-12 | the source found 0 · this programme has 153 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("PTEN deletion" OR "intrinsic growth capacity" OR "SOCS3") - Crossref
spinal cord injury PTEN deletion intrinsic growth capacity - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("PTEN Phosphohydrolase"[MeSH Terms] OR "PTEN deletion"[Title/Abstract] OR "intrinsic growth capacity"[Title/Abstract] OR "SOCS3"[Title/Abstract])