A subject this map covers
Macrophage therapy and polarisation
Part of: Inflammation and immune response
What belongs here
Delivering or reprogramming macrophages to change the character of inflammation at the injury.
What does not belong here, however close it looks
Describing what macrophages do without intervening is mechanism, not therapy; such a record stays in the parent concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 265 records · 1967–2026
- Indexed as work in animals: 781 records · 1966–2026
- Indexed as laboratory work: 41 records · 1988–2026
- The source has not said who or what was studied: 211 records · 1999–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1298 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord. — PubMed · 2020 · Journal Article
- HDAC8 Inhibition Reduces Lesional Iba-1+ Cell Infiltration after Spinal Cord Injury without Effects on Functional Recovery. — PubMed · 2020 · Journal Article
- Adipose mesenchymal stem cell transplantation alleviates spinal cord injury-induced neuroinflammation partly by suppressing the Jagged1/Notch pathway. — PubMed · 2020 · Journal Article
- Modulation of inflammatory factors predicts the outcome following spinal cord injury. — PubMed · 2020 · Journal Article
- MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury. — PubMed · 2020 · Journal Article
- RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo. — PubMed · 2020 · Journal Article
- LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3. — PubMed · 2020 · Journal Article
- Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization. — PubMed · 2020 · Journal Article
- A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation. — PubMed · 2020 · Journal Article
- Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage-Mediated Activation of Wnt/β-Catenin Pathway. — PubMed · 2020 · Journal Article
- Riluzole improves functional recovery after acute spinal cord injury in rats and may be associated with changes in spinal microglia/macrophages polarization. — PubMed · 2020 · Journal Article
- Knockdown of macrophage migration inhibitory factor (MIF), a novel target to protect neurons from parthanatos induced by simulated post-spinal cord injury oxidative stress. — PubMed · 2020 · Journal Article
- Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2. — PubMed · 2020 · Journal Article
- Safe range of shortening the middle thoracic spine, an experimental study in canine. — PubMed · 2020 · Journal Article
- The effects of the M2a macrophage-induced axonal regeneration of neurons by arginase 1. — PubMed · 2020 · Journal Article The source marks this record as retracted.
- Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury. — PubMed · 2020 · Journal Article
- Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury. — PubMed · 2020 · Journal Article
- Isolation and RNA purification of macrophages/microglia from the adult mouse spinal cord. — PubMed · 2020 · Journal Article
- Transplantation of M2-Deviated Microglia Promotes Recovery of Motor Function after Spinal Cord Injury in Mice. — PubMed · 2020 · Journal Article
- Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury. — PubMed · 2020 · Journal Article
- Invasion of microglia/macrophages and granulocytes into the Mauthner axon myelin sheath following spinal cord injury of the adult goldfish, Carassius auratus. — PubMed · 2020 · Journal Article
- Low-level laser therapy 810-nm up-regulates macrophage secretion of neurotrophic factors via PKA-CREB and promotes neuronal axon regeneration in vitro. — PubMed · 2020 · Journal Article
- Photobiomodulation Therapy Inhibit the Activation and Secretory of Astrocytes by Altering Macrophage Polarization. — PubMed · 2020 · Journal Article
- MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Bisperoxovanadium induces M2-type macrophages and promotes functional recovery after spinal cord injury. — PubMed · 2019 · Journal Article
- Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury. — PubMed · 2019 · Journal Article
- Effect of curcumin on the inflammatory reaction and functional recovery after spinal cord injury in a hyperglycemic rat model. — PubMed · 2019 · Journal Article
- Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice. — PubMed · 2019 · Journal Article
- Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats. — PubMed · 2019 · Journal Article
- Neuroectodermal Stem Cells Grafted into the Injured Spinal Cord Induce Both Axonal Regeneration and Morphological Restoration via Multiple Mechanisms. — PubMed · 2019 · Journal Article
- Role of macrophages and activated microglia in neuropathic pain associated with chronic progressive spinal cord compression. — PubMed · 2019 · Journal Article
- Prospects of siRNA cocktails as tools for modifying multiple gene targets in the injured spinal cord. — PubMed · 2019 · Journal Article
- TMEM16F inhibition limits pain-associated behavior and improves motor function by promoting microglia M2 polarization in mice. — PubMed · 2019 · Journal Article
- ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury. — PubMed · 2019 · Journal Article
- Effect of M2 macrophage adoptive transfer on transcriptome profile of injured spinal cords in rats. — PubMed · 2019 · Journal Article
- Inhibition of NOX2 signaling limits pain-related behavior and improves motor function in male mice after spinal cord injury: Participation of IL-10/miR-155 pathways. — PubMed · 2019 · Journal Article
- Sexual Dimorphism of Pain Control: Analgesic Effects of Pioglitazone and Azithromycin in Chronic Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury. — PubMed · 2019 · Journal Article
- Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury. — PubMed · 2019 · Journal Article
- Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages. — PubMed · 2019 · Journal Article
- Morphine increases macrophages at the lesion site following spinal cord injury: Protective effects of minocycline. — PubMed · 2019 · Journal Article
- Intraspinal administration of interleukin-7 promotes neuronal apoptosis and limits functional recovery through JAK/STAT5 pathway following spinal cord injury. — PubMed · 2019 · Journal Article
- Functional and Histological Gender Comparison of Age-Matched Rats after Moderate Thoracic Contusive Spinal Cord Injury. — PubMed · 2019 · Comparative Study
- BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury. — PubMed · 2019 · Journal Article
- Macrophage Migration Inhibitory Factor Promotes Chemotaxis of Astrocytes through Regulation of Cholesterol 25-Hydroxylase Following Rat Spinal Cord Injury. — PubMed · 2019 · Journal Article
- The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury. — PubMed · 2019 · Journal Article
- Macrophage centripetal migration drives spontaneous healing process after spinal cord injury. — PubMed · 2019 · Journal Article
- Inhibition of NLRP3 inflammasome attenuates spinal cord injury-induced lung injury in mice. — PubMed · 2019 · Journal Article
- Macrolide derivatives reduce proinflammatory macrophage activation and macrophage-mediated neurotoxicity. — PubMed · 2019 · Journal Article
- Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury. — PubMed · 2019 · Journal Article
- Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy. — PubMed · 2019 · Journal Article
- Macrophage migration inhibitory factor facilitates prostaglandin E(2) production of astrocytes to tune inflammatory milieu following spinal cord injury. — PubMed · 2019 · Journal Article
- Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. — PubMed · 2019 · Journal Article
- miR-940 promotes spinal cord injury recovery by inhibiting TLR4/NF-κB pathway-mediated inflammation. — PubMed · 2019 · Journal Article
- Nucleic Acid Vaccine Targeting Nogo-66 Receptor and Paired Immunoglobulin-Like Receptor B as an Immunotherapy Strategy for Spinal Cord Injury in Rats. — PubMed · 2019 · Journal Article
- Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Astrocyte progenitor transplantation promotes regeneration of bulbospinal respiratory axons, recovery of diaphragm function, and a reduced macrophage response following cervical spinal cord injury. — PubMed · 2019 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1037078 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 4 · this programme has 1301 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("macrophage" OR "macrophage polarization" OR "autologous incubated macrophage") - Crossref
spinal cord injury macrophage macrophage polarization - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Macrophages"[MeSH Terms] OR "macrophage"[Title/Abstract] OR "macrophage polarization"[Title/Abstract] OR "autologous incubated macrophage"[Title/Abstract])