A subject this map covers
Macrophage therapy and polarisation
Part of: Inflammation and immune response
What belongs here
Delivering or reprogramming macrophages to change the character of inflammation at the injury.
What does not belong here, however close it looks
Describing what macrophages do without intervening is mechanism, not therapy; such a record stays in the parent concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 265 records · 1967–2026
- Indexed as work in animals: 781 records · 1966–2026
- Indexed as laboratory work: 41 records · 1988–2026
- The source has not said who or what was studied: 211 records · 1999–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1298 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Exosomal OTULIN from M2 macrophages promotes the recovery of spinal cord injuries via stimulating Wnt/β-catenin pathway-mediated vascular regeneration. — PubMed · 2021 · Journal Article
- Exosomes-mediated phenotypic switch of macrophages in the immune microenvironment after spinal cord injury. — PubMed · 2021 · Journal Article
- Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice. — PubMed · 2021 · Journal Article
- Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats. — PubMed · 2021 · Journal Article
- Engineered extracellular vesicles derived from primary M2 macrophages with anti-inflammatory and neuroprotective properties for the treatment of spinal cord injury. — PubMed · 2021 · Journal Article
- Chondroitin 6-sulfate-binding peptides improve recovery in spinal cord-injured mice. — PubMed · 2021 · Journal Article
- Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury. — PubMed · 2021 · Journal Article
- Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway. — PubMed · 2021 · Journal Article
- Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair. — PubMed · 2021 · Journal Article
- Cervical spinal cord injury-induced neuropathic pain in male mice is associated with a persistent pro-inflammatory macrophage/microglial response in the superficial dorsal horn. — PubMed · 2021 · Journal Article
- [Necrostatin-1 promotes locomotor recovery after spinal cord injury through inhibiting apoptosis and M1 polarization of microglia/macrophage in mice]. — PubMed · 2021 · Journal Article
- S100-β aggravates spinal cord injury via activation of M1 macrophage phenotype. — PubMed · 2021 · Journal Article
- Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-β upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury. — PubMed · 2021 · Journal Article
- Keratin Biomaterials Improve Functional Recovery in a Rat Spinal Cord Injury Model. — PubMed · 2021 · Journal Article
- Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord. — PubMed · 2021 · Journal Article
- Liver inflammation at the time of spinal cord injury enhances intraspinal pathology, liver injury, metabolic syndrome and locomotor deficits. — PubMed · 2021 · Journal Article
- Nerve growth factor loaded macrophage-derived nanovesicles for inhibiting neuronal apoptosis after spinal cord injury. — PubMed · 2021 · Journal Article
- Activation of Neuroprotective Microglia and Astrocytes at the Lesion Site and in the Adjacent Segments Is Crucial for Spontaneous Locomotor Recovery after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Effect of humic acid on oxidative stress and neuroprotection in traumatic spinal cord injury: an experimental study. — PubMed · 2021 · Journal Article
- The Conditioned Medium of Lactobacillus rhamnoides GG Regulates Microglia/Macrophage Polarization and Improves Functional Recovery after Spinal Cord Injury in Rats. — PubMed · 2021 · Journal Article The source marks this record as retracted.
- Targeting senescent cells improves functional recovery after spinal cord injury. — PubMed · 2021 · Journal Article
- Proteomics and bioinformatics reveal insights into neuroinflammation in the acute to subacute phases in rat models of spinal cord contusion injury. — PubMed · 2021 · Journal Article
- Design and development of 1,3,5-triazine derivatives as protective agent against spinal cord injury in rat via inhibition of NF-ĸB. — PubMed · 2021 · Journal Article
- Photobiomodulation Promotes Neuronal Axon Regeneration After Oxidative Stress and Induces a Change in Polarization from M1 to M2 in Macrophages via Stimulation of CCL2 in Neurons: Relevance to Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Transplantation of tauroursodeoxycholic acid-inducing M2-phenotype macrophages promotes an anti-neuroinflammatory effect and functional recovery after spinal cord injury in rats. — PubMed · 2021 · Journal Article
- Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord. — PubMed · 2021 · Journal Article
- Programmed death protein 1 is essential for maintaining the anti-inflammatory function of infiltrating regulatory T cells in a murine spinal cord injury model. — PubMed · 2021 · Journal Article
- Acute inflammatory profiles differ with sex and age after spinal cord injury. — PubMed · 2021 · Journal Article
- Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy. — PubMed · 2021 · Journal Article
- Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5. — PubMed · 2021 · Journal Article
- CCR2 downregulation attenuates spinal cord injury by suppressing inflammatory monocytes. — PubMed · 2021 · Journal Article
- CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. — PubMed · 2021 · Journal Article
- Impact of Depletion of Microglia/Macrophages on Regeneration after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Peripheral Macrophage-derived Exosomes promote repair after Spinal Cord Injury by inducing Local Anti-inflammatory type Microglial Polarization via Increasing Autophagy. — PubMed · 2021 · Journal Article
- Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury. — PubMed · 2021 · Journal Article
- Isorhamnetin promotes functional recovery in rats with spinal cord injury by abating oxidative stress and modulating M2 macrophages/microglia polarization. — PubMed · 2021 · Journal Article
- Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson's disease. — PubMed · 2021 · Journal Article
- Ketone Metabolite β-Hydroxybutyrate Ameliorates Inflammation After Spinal Cord Injury by Inhibiting the NLRP3 Inflammasome. — PubMed · 2021 · Journal Article
- Role of MK2 signaling pathway mediating microglia/macrophages polarization in chronic compression injury of cervical spinal cord. — PubMed · 2021 · Journal Article
- Utx Regulates the NF-κB Signaling Pathway of Natural Stem Cells to Modulate Macrophage Migration during Spinal Cord Injury. — PubMed · 2021 · Journal Article
- NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury. — PubMed · 2021 · Journal Article
- Exercise Ameliorates Spinal Cord Injury by Changing DNA Methylation. — PubMed · 2021 · Journal Article
- Azathioprine as a Neuroprotective Agent in Experimental Traumatic Spinal Cord Injury. — PubMed · 2021 · Journal Article
- MicroRNA-22-3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5. — PubMed · 2021 · Journal Article
- Neonatal Rats Exhibit a Predominantly Anti-Inflammatory Response following Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Neurologic and Histologic Tests Used to Measure Neuroprotective Effectiveness of Virus-Derived Immune-Modulating Proteins. — PubMed · 2021 · Journal Article
- Resolvin D3 Promotes Inflammatory Resolution, Neuroprotection, and Functional Recovery After Spinal Cord Injury. — PubMed · 2021 · Journal Article
- The relationship between macrophage polarization and glial scar formation in mouse model of spinal cord injury. — PubMed · 2020 · Journal Article
- CCL3 contributes to secondary damage after spinal cord injury. — PubMed · 2020 · Journal Article
- Conditional Ablation of Myeloid TNF Improves Functional Outcome and Decreases Lesion Size after Spinal Cord Injury in Mice. — PubMed · 2020 · Journal Article
- Red-Light (670 nm) Therapy Reduces Mechanical Sensitivity and Neuronal Cell Death, and Alters Glial Responses after Spinal Cord Injury in Rats. — PubMed · 2020 · Journal Article
- Time-dependent microglia and macrophages response after traumatic spinal cord injury in rat: a systematic review. — PubMed · 2020 · Journal Article
- The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury. — PubMed · 2020 · Journal Article
- Distribution and polarization of microglia and macrophages at injured sites and the lumbar enlargement after spinal cord injury. — PubMed · 2020 · Journal Article
- Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury. — PubMed · 2020 · Journal Article
- Attenuation of the inflammatory response and polarization of macrophages by photobiomodulation. — PubMed · 2020 · Journal Article
- Duraplasty of PHBV/PLA/Col membranes promotes axonal regeneration by inhibiting NLRP3 complex and M1 macrophage polarization in rats with spinal cord injury. — PubMed · 2020 · Journal Article
- Improved locomotor recovery after contusive spinal cord injury in Bmal1(-/-) mice is associated with protection of the blood spinal cord barrier. — PubMed · 2020 · Journal Article
- Effect of VX‑765 on the transcriptome profile of mice spinal cords with acute injury. — PubMed · 2020 · Journal Article
- Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice. — PubMed · 2020 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1037078 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 4 · this programme has 1301 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("macrophage" OR "macrophage polarization" OR "autologous incubated macrophage") - Crossref
spinal cord injury macrophage macrophage polarization - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Macrophages"[MeSH Terms] OR "macrophage"[Title/Abstract] OR "macrophage polarization"[Title/Abstract] OR "autologous incubated macrophage"[Title/Abstract])