A subject this map covers
Minocycline
Part of: Neuroprotection
What belongs here
The antibiotic with anti-inflammatory action trialled as a neuroprotectant.
What does not belong here, however close it looks
Its use as an ordinary antibiotic does not belong here.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 51 records · 1991–2026
- Indexed as work in animals: 55 records · 2003–2023
- Indexed as laboratory work: 2 records · 2013–2013
- The source has not said who or what was studied: 68 records · 1977–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
176 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Therapeutic Effects of Minocycline Pretreatment in the Locomotor and Sensory Complications of Spinal Cord Injury in an Animal Model. — PubMed · 2020 · Journal Article
- Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury. — PubMed · 2020 · Journal Article
- Effects of combined treatment of minocycline and methylprednisolone on the expression of tumor necrosis factor alpha and interleukine-6 in experimental spinal cord injury: a light and electron microscopic study. — PubMed · 2020 · Journal Article
- Neuronal activity and microglial activation support corticospinal tract and proprioceptive afferent sprouting in spinal circuits after a corticospinal system lesion. — PubMed · 2019 · Journal Article
- A zebrafish drug screening platform boosts the discovery of novel therapeutics for spinal cord injury in mammals. — PubMed · 2019 · Journal Article
- A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function. — PubMed · 2019 · Journal Article
- Morphine increases macrophages at the lesion site following spinal cord injury: Protective effects of minocycline. — PubMed · 2019 · Journal Article
- Can Minocycline Become the Magic Pill of Spinal Cord Protection? — PubMed · 2019 · Editorial
- Polysialic-Acid-Based Micelles Promote Neural Regeneration in Spinal Cord Injury Therapy. — PubMed · 2019 · Journal Article
- Minocycline Reduces the Severity of Autonomic Dysreflexia after Experimental Spinal Cord Injury. — PubMed · 2018 · Journal Article
- Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy. — PubMed · 2018 · Journal Article
- Nano-carrier mediated co-delivery of methyl prednisolone and minocycline for improved post-traumatic spinal cord injury conditions in rats. — PubMed · 2017 · Journal Article
- In vivo evaluation of microglia activation by intracranial iron overload in central pain after spinal cord injury. — PubMed · 2017 · Evaluation Study
- Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury. — PubMed · 2017 · Journal Article
- Effectiveness of minocycline and FK506 alone and in combination on enhanced behavioral and biochemical recovery from spinal cord injury in rats. — PubMed · 2016 · Journal Article
- Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury. — PubMed · 2016 · Journal Article
- Bone marrow mesenchymal stem cells combined with minocycline improve spinal cord injury in a rat model. — PubMed · 2015 · Journal Article
- High-frequency transcutaneous electrical nerve stimulation alleviates spasticity after spinal contusion by inhibiting activated microglia in rats. — PubMed · 2015 · Journal Article
- The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. — PubMed · 2014 · Journal Article
- An examination of the mechanisms by which neural precursors augment recovery following spinal cord injury: a key role for remyelination. — PubMed · 2014 · Journal Article
- Minocycline inhibited the pro-apoptotic effect of microglia on neural progenitor cells and protected their neuronal differentiation in vitro. — PubMed · 2013 · Journal Article
- Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. — PubMed · 2012 · Journal Article
- Is minocycline useful for therapy of acute viral encephalitis? — PubMed · 2012 · Journal Article
- Axon-glia synapses are highly vulnerable to white matter injury in the developing brain. — PubMed · 2012 · Journal Article
- Anti-inflammatory treatments during the chronic phase of spinal cord injury improve locomotor function in adult mice. — PubMed · 2011 · Journal Article
- Activated microglia inhibit axonal growth through RGMa. — PubMed · 2011 · Journal Article
- Lack of neuroprotective effects of simvastatin and minocycline in a model of cervical spinal cord injury. — PubMed · 2010 · Journal Article
- Reducing macrophages to improve bone marrow stromal cell survival in the contused spinal cord. — PubMed · 2010 · Journal Article
- Effects of Etanercept and Minocycline in a rat model of spinal cord injury. — PubMed · 2009 · Journal Article
- Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury. — PubMed · 2009 · Journal Article
- A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model. — PubMed · 2008 · Journal Article
- Pregabalin as a neuroprotector after spinal cord injury in rats. — PubMed · 2008 · Journal Article
- Limited minocycline neuroprotection after balloon-compression spinal cord injury in the rat. — PubMed · 2008 · Journal Article
- Modulation of thalamic nociceptive processing after spinal cord injury through remote activation of thalamic microglia by cysteine cysteine chemokine ligand 21. — PubMed · 2007 · Journal Article
- Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. — PubMed · 2007 · Journal Article
- Extracellular signal-regulated kinase-regulated microglia-neuron signaling by prostaglandin E2 contributes to pain after spinal cord injury. — PubMed · 2007 · Journal Article
- Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury. — PubMed · 2006 · Journal Article
- Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. — PubMed · 2006 · Comparative Study
- Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. — PubMed · 2006 · Journal Article
- Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. — PubMed · 2004 · Journal Article
- The contribution of activated phagocytes and myelin degeneration to axonal retraction/dieback following spinal cord injury. — PubMed · 2004 · Comparative Study
- Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse. — PubMed · 2004 · Journal Article
- Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. — PubMed · 2004 · Journal Article
- Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury. — PubMed · 2004 · Journal Article
- Leukemia inhibitory factor promotes recovery of locomotor function following spinal cord injury in the mouse. — PubMed · 2003 · Comparative Study
- Minocycline reduces cell death and improves functional recovery after traumatic spinal cord injury in the rat. — PubMed · 2003 · Comparative Study
Indexed as laboratory work
- Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury. — PubMed · 2013 · Journal Article
- Prolonged minocycline treatment impairs motor neuronal survival and glial function in organotypic rat spinal cord cultures. — PubMed · 2013 · Journal Article
The source has not said who or what was studied
- Minocycline in Acute Traumatic Spinal Cord Injury: A Systematic Review and Exploratory Meta-Analysis of Preclinical and Clinical Evidence. — PubMed · 2026 · Journal Article
- Acute spinal cord injury: contemporary management and novel therapies. — PubMed · 2026 · Journal Article
- Efficacy of Minocycline in Acute Traumatic Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Potential Pharmacologic Treatments in Spinal Cord Injury: A Narrative Review. — PubMed · 2025 · Journal Article
- Intravenously injected poly(amino acid) nanoformulation relieves spinal cord injury through synergistical modulation of microenvironments. — PubMed · 2025 · Journal Article
- Preparation of a minocycline polymer micelle thermosensitive gel and its application in spinal cord injury. — PubMed · 2024 · Journal Article
- Minocycline as Potential Neuroprotector through Neuroinflammation Halting Mechanism in Spinal Cord Injury: Literature Review — Crossref · 2024 · journal-article
- Microglial activation in the motor cortex mediated NLRP3-related neuroinflammation and neuronal damage following spinal cord injury. — PubMed · 2022 · Journal Article
- Regulation of neuronal repair and regeneration through inhibition of oligodendrocyte myelin glycoprotein (OMgp). — PubMed · 2022 · Journal Article
- Spinal cord injury pain: A retrospective — Crossref · 2022 · book-chapter
- Minocycline Enhance the Restorative Ability of Olfactory Ensheathing Cells by the Upregulation of BDNF and GDNF Expression After Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Ivermectin-functionalized multiwall carbon nanotube enhanced the locomotor activity and neuropathic pain by modulating M1/M2 macrophage and decrease oxidative stress in rat model of spinal cord injury. — PubMed · 2021 · Journal Article The source marks this record as retracted.
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 3 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 813973 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 1 · this programme has 136 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("minocycline") - Crossref
spinal cord injury minocycline - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Minocycline"[MeSH Terms] OR "minocycline"[Title/Abstract])