A subject this map covers
Minocycline
Part of: Neuroprotection
What belongs here
The antibiotic with anti-inflammatory action trialled as a neuroprotectant.
What does not belong here, however close it looks
Its use as an ordinary antibiotic does not belong here.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 51 records · 1991–2026
- Indexed as work in animals: 55 records · 2003–2023
- Indexed as laboratory work: 2 records · 2013–2013
- The source has not said who or what was studied: 68 records · 1977–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
176 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Lost in translation: why pharmacological trials keep failing in acute spinal cord injury. — PubMed · 2026 · Journal Article
- Reprogramming the Inflammatory Response to Promote Neural Stem Cell Function After Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Exploring the Effectiveness and Potential Pharmacological Mechanism of Minocycline for Spinal Cord Injury through Meta-Analysis and Network Pharmacology. — PubMed · 2025 · Journal Article
- Pharmacologic Therapy for Spinal Cord Injury. — PubMed · 2024 · Journal Article
- An updated systematic review of neuroprotective agents in the treatment of spinal cord injury. — PubMed · 2024 · Systematic Review
- A critical appraisal of clinical practice guidelines on pharmacological treatments for spinal cord injury. — PubMed · 2023 · Systematic Review
- Reconnoitering the transformative journey of minocycline from an antibiotic to an antiepileptic drug. — PubMed · 2022 · Journal Article
- Acute spinal cord injury: Pathophysiology and pharmacological intervention (Review). — PubMed · 2021 · Journal Article
- Antibiotics with therapeutic effects on spinal cord injury: a review. — PubMed · 2021 · Journal Article
- Neuroprotective Agents as an Adjuvant Treatment in Patients With Acute Spinal Cord Injuries: A Qualitative Systematic Review of Randomized Trials. — PubMed · 2020 · Journal Article
- Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles. — PubMed · 2019 · Journal Article
- Time is spine: a review of translational advances in spinal cord injury. — PubMed · 2018 · Journal Article
- Cerebrospinal Fluid Biomarkers in Human Spinal Cord Injury from a Phase II Minocycline Trial. — PubMed · 2018 · Clinical Trial, Phase II
- Minocycline as a promising therapeutic strategy for chronic pain. — PubMed · 2018 · Journal Article
- Traumatic Spinal Cord Injury-Repair and Regeneration. — PubMed · 2017 · Journal Article
- Predicting Recruitment Feasibility for Acute Spinal Cord Injury Clinical Trials in Canada Using National Registry Data. — PubMed · 2017 · Journal Article
- Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury. — PubMed · 2016 · Journal Article
- Mediating the Secondary Effects of Spinal Cord Injury Through Optimization of Key Physiologic Parameters. — PubMed · 2016 · Journal Article
- Acute Spinal Cord Injury. — PubMed · 2015 · Journal Article
- Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from Phase I to II. — PubMed · 2015 · Journal Article
- Recent advances in the pharmacologic treatment of spinal cord injury. — PubMed · 2015 · Journal Article
- Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome. — PubMed · 2015 · Comparative Study
- Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury. — PubMed · 2015 · Journal Article
- Immune modulatory therapies for spinal cord injury--past, present and future. — PubMed · 2014 · Journal Article
- Neuroinflammatory contributions to pain after SCI: roles for central glial mechanisms and nociceptor-mediated host defense. — PubMed · 2014 · Journal Article
- The therapeutic role of interleukin-10 after spinal cord injury. — PubMed · 2013 · Journal Article
- Minocycline treatment inhibits lipid peroxidation, preserves spinal cord ultrastructure, and improves functional outcome after traumatic spinal cord injury in the rat. — PubMed · 2013 · Journal Article
- Minocycline in Acute Spinal Cord Injury (MASC) — ClinicalTrials.gov · 2013 · Interventional · Unknown
- Minocycline: far beyond an antibiotic. — PubMed · 2013 · Journal Article
- Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement — ClinicalTrials.gov · 2013 · Interventional · Unknown
- Emerging therapies for acute traumatic spinal cord injury. — PubMed · 2013 · Journal Article
- When is the time right for a Phase III clinical study in spinal cord injury (P = 0.05)? — PubMed · 2012 · Letter
- Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury. — PubMed · 2012 · Journal Article
- Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. — PubMed · 2012 · Clinical Trial, Phase II
- A systematic review of directly applied biologic therapies for acute spinal cord injury. — PubMed · 2011 · Journal Article
- A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. — PubMed · 2011 · Journal Article
- Emerging repair, regeneration, and translational research advances for spinal cord injury. — PubMed · 2010 · Journal Article
- A gastric hormone to treat spinal cord injury? — PubMed · 2010 · Comment
- Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury. — PubMed · 2010 · Journal Article
- Minocycline and neurodegenerative diseases. — PubMed · 2009 · Journal Article
- Inflammation: beneficial or detrimental after spinal cord injury? — PubMed · 2008 · Journal Article
- Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury. — PubMed · 2008 · Journal Article
- p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action. — PubMed · 2007 · Journal Article
- Update on the treatment of spinal cord injury. — PubMed · 2007 · Journal Article
- Pharmacological approaches to repair the injured spinal cord. — PubMed · 2006 · Journal Article
- Strategies to promote neural repair and regeneration after spinal cord injury. — PubMed · 2005 · Journal Article
- Current status of clinical trials for acute spinal cord injury. — PubMed · 2005 · Journal Article
- Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions. — PubMed · 2005 · Comparative Study
- The promise of minocycline in neurology. — PubMed · 2004 · Journal Article
- Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury — ClinicalTrials.gov · 2004 · Interventional · Completed
- Eradication of colonization by methicillin-resistant Staphylococcus aureus by using oral minocycline-rifampin and topical mupirocin. — PubMed · 1991 · Journal Article
Indexed as work in animals
- IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. — PubMed · 2023 · Journal Article
- Minocycline relieves neuropathic pain in rats with spinal cord injury via activation of autophagy and suppression of PI3K/Akt/mTOR pathway. — PubMed · 2023 · Journal Article
- Intrathecal minocycline does not block the adverse effects of repeated, intravenous morphine administration on recovery of function after SCI. — PubMed · 2023 · Journal Article
- Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. — PubMed · 2022 · Journal Article
- Minocycline-Loaded Poly(α-Lipoic Acid)-Methylprednisolone Prodrug Nanoparticles for the Combined Anti-Inflammatory Treatment of Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota. — PubMed · 2021 · Journal Article
- Effects of minocycline on motor function recovery and expression of glial fibrillary acidic protein and brain-derived neurotrophic factor after spinal cord injury in rats. — PubMed · 2021 · Journal Article
- Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson's disease. — PubMed · 2021 · Journal Article
- Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury. — PubMed · 2021 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 3 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 813973 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 1 · this programme has 136 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("minocycline") - Crossref
spinal cord injury minocycline - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Minocycline"[MeSH Terms] OR "minocycline"[Title/Abstract])