A subject this map covers
Riluzole
Part of: Neuroprotection
What belongs here
The sodium-channel blocker trialled as a neuroprotectant in acute injury.
What does not belong here, however close it looks
Its use in amyotrophic lateral sclerosis does not belong here.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 64 records · 1997–2026
- Indexed as work in animals: 38 records · 1997–2026
- Indexed as laboratory work: 2 records · 2009–2016
- The source has not said who or what was studied: 69 records · 1977–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
173 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury. — PubMed · 2008 · Journal Article
- Pharmacological approaches to repair the injured spinal cord. — PubMed · 2006 · Journal Article
- Current status of clinical trials for acute spinal cord injury. — PubMed · 2005 · Journal Article
- Traditional pharmacological treatments for spasticity. Part II: General and regional treatments. — PubMed · 1997 · Journal Article
Indexed as work in animals
- Anti-inflammatory treatment confirms rsfMRI and TSPO PET as biomarkers of functional connectivity and neuroinflammation in rat contusion spinal cord injuries. — PubMed · 2026 · Journal Article
- Validation of qMT and CEST MRI as Biomarkers of Response to Treatment After Lumbar Spinal Cord Injury in Rats. — PubMed · 2025 · Journal Article
- A Single Administration of Riluzole Applied Acutely After Spinal Cord Injury Attenuates Pro-inflammatory Activity and Improves Long-Term Functional Recovery in Rats. — PubMed · 2022 · Journal Article
- The use of a detailed video-based locomotor pattern analysis system to assess the functional reinnervation of denervated hind limb muscles. — PubMed · 2022 · Journal Article
- Why do anti-inflammatory signals of bone marrow-derived stromal cells improve neurodegenerative conditions where anti-inflammatory drugs fail? — PubMed · 2020 · Journal Article
- Riluzole improves functional recovery after acute spinal cord injury in rats and may be associated with changes in spinal microglia/macrophages polarization. — PubMed · 2020 · Journal Article
- A zebrafish drug screening platform boosts the discovery of novel therapeutics for spinal cord injury in mammals. — PubMed · 2019 · Journal Article
- Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta-analysis and systematic review. — PubMed · 2019 · Journal Article
- Pharmacokinetics of Riluzole in Beagle Dogs. — PubMed · 2019 · Journal Article
- Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats. — PubMed · 2018 · Journal Article
- Prophylactic Riluzole Attenuates Oxidative Stress Damage in Spinal Cord Distraction. — PubMed · 2018 · Journal Article
- Effect of Riluzole on Spinal Cord Regeneration with Hemisection Method Before Injury. — PubMed · 2018 · Journal Article
- Association of riluzole and dantrolene improves significant recovery after acute spinal cord injury in rats. — PubMed · 2018 · Journal Article
- Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist riluzole in experimental spinal cord injury. — PubMed · 2017 · Journal Article
- Combining neuroprotective agents: effect of riluzole and magnesium in a rat model of thoracic spinal cord injury. — PubMed · 2016 · Journal Article
- Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection. — PubMed · 2016 · Journal Article
- Evaluation of the effects of riluzole on adult spinal cord-derived neural stem/progenitor cells in vitro and in vivo. — PubMed · 2015 · Journal Article
- A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury. — PubMed · 2015 · Comparative Study
- Riluzole effects on behavioral sensitivity and the development of axonal damage and spinal modifications that occur after painful nerve root compression. — PubMed · 2014 · Journal Article
- The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. — PubMed · 2014 · Journal Article
- Delayed post-injury administration of riluzole is neuroprotective in a preclinical rodent model of cervical spinal cord injury. — PubMed · 2013 · Journal Article
- The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord. — PubMed · 2013 · Journal Article
- A study of the potential neuroprotective effect of riluzole on locomotor networks of the neonatal rat spinal cord in vitro damaged by excitotoxicity. — PubMed · 2012 · Journal Article
- Comparative effects of glibenclamide and riluzole in a rat model of severe cervical spinal cord injury. — PubMed · 2012 · Comparative Study
- Effectiveness of riluzole in suppressing spasticity in the spinal cord injured rat. — PubMed · 2009 · Journal Article
- Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury. — PubMed · 2007 · Comparative Study
- Delayed riluzole treatment is able to rescue injured rat spinal motoneurons. — PubMed · 2007 · Journal Article
- Riluzole promotes cell survival and neurite outgrowth in rat sensory neurones in vitro. — PubMed · 2006 · Journal Article
- Persistent sodium currents and repetitive firing in motoneurons of the sacrocaudal spinal cord of adult rats. — PubMed · 2006 · Journal Article
- The effect of glutamate receptor blockers on glutamate release following spinal cord injury. Lack of evidence for an ongoing feedback cascade of damage --> glutamate release --> damage --> glutamate release --> etc. — PubMed · 2005 · Comparative Study
- Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole. — PubMed · 2001 · Journal Article
- Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury. — PubMed · 2000 · Journal Article
- Ischemic spinal cord injury induced by aortic cross-clamping: prevention by riluzole. — PubMed · 2000 · Comparative Study
- Prevention of ischemic spinal cord injury: comparative effects of magnesium sulfate and riluzole. — PubMed · 2000 · Comparative Study
- A word of caution in extrapolating the riluzole spinal cord injury protective effects obtained in a rabbit model under ketamine anesthesia. — PubMed · 1999 · Comment
- Riluzole prevents ischemic spinal cord injury caused by aortic crossclamping. — PubMed · 1999 · Comparative Study
- Neuroprotective effects of riluzole in neurotrauma models: a review. — PubMed · 1999 · Journal Article
- Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment. — PubMed · 1997 · Journal Article
Indexed as laboratory work
- Electrospun Fibers for Drug Delivery after Spinal Cord Injury and the Effects of Drug Incorporation on Fiber Properties. — PubMed · 2016 · Journal Article
- Drug screening of neuroprotective agents on an organotypic-based model of spinal cord excitotoxic damage. — PubMed · 2009 · Journal Article
The source has not said who or what was studied
- Ion channel and receptor-mediated regulation of axonal conduction reliability in sympathetic preganglionic neurons. — PubMed · 2026 · Journal Article
- AO Spine Clinical Practice Recommendations for Adjunctive Medical Therapies in Acute Traumatic Spinal Cord Injury: Contemporary Concepts. — PubMed · 2026 · Journal Article
- Acute spinal cord injury: contemporary management and novel therapies. — PubMed · 2026 · Journal Article
- Pharmacotherapy in the acute phase of secondary spinal cord injury: an updated narrative review. — PubMed · 2026 · Journal Article
- 938: RILUZOLE FOR MOTOR RECOVERY IN PATIENTS WITH TRAUMATIC SPINAL CORD INJURY — Crossref · 2026 · journal-article
- Potential Pharmacologic Treatments in Spinal Cord Injury: A Narrative Review. — PubMed · 2025 · Journal Article
- Conservative and newer drug treatment for degenerative cervical myelopathy. — PubMed · 2025 · Journal Article
- Traumatic spinal cord injury: a review of the current state of art and future directions - what do we know and where are we going? — PubMed · 2025 · Journal Article
- Riluzole is Effective on Spinal Decompression for Treating Acute Spinal Injury When Compared With Methylprednisolone and the Combination of Two Drugs: In Vivo Rat Model. — PubMed · 2024 · Journal Article
- Safety and Efficacy of Riluzole in Traumatic Spinal Cord Injury: A Systematic Review With Meta-Analyses. — PubMed · 2024 · Journal Article
- The Role of Riluzole in Acute Traumatic Cervical Spinal Cord Injury with Incomplete Neurological Deficit: A Prospective, Randomised Controlled Study. — PubMed · 2022 · Journal Article
- Regulation of neuronal repair and regeneration through inhibition of oligodendrocyte myelin glycoprotein (OMgp). — PubMed · 2022 · Journal Article
- Spinal cord injury pain: A retrospective — Crossref · 2022 · book-chapter
- An observation of the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen in treating acute spinal cord injury. — PubMed · 2021 · Journal Article
- Pharmacologic and Regenerative Cell Therapy for Spinal Cord Injury: WFNS Spine Committee Recommendations. — PubMed · 2020 · Journal Article
- The Impact of Riluzole on Neurobehavioral Outcomes in Preclinical Models of Traumatic and Nontraumatic Spinal Cord Injury: Results From a Systematic Review of the Literature. — PubMed · 2020 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 4 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 810282 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 132 · this programme has 132 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("riluzole") - Crossref
spinal cord injury riluzole - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Riluzole"[MeSH Terms] OR "riluzole"[Title/Abstract])