A subject this map covers
Riluzole
Part of: Neuroprotection
What belongs here
The sodium-channel blocker trialled as a neuroprotectant in acute injury.
What does not belong here, however close it looks
Its use in amyotrophic lateral sclerosis does not belong here.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 64 records · 1997–2026
- Indexed as work in animals: 38 records · 1997–2026
- Indexed as laboratory work: 2 records · 2009–2016
- The source has not said who or what was studied: 69 records · 1977–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
173 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Neuroprotection of the Compressed Spine: A Systematized Narrative Review of Riluzole for Humans with Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Lost in translation: why pharmacological trials keep failing in acute spinal cord injury. — PubMed · 2026 · Journal Article
- Riluzole in neuroinflammation and neurodegeneration: Mechanistic insights and experimental validation. — PubMed · 2026 · Journal Article
- Diagnosis and Management of Degenerative Cervical Myelopathy. — PubMed · 2025 · Journal Article
- Riluzole as a pharmacological therapy for spinal cord injury: where does this therapy stand? — PubMed · 2025 · Journal Article
- The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique. — PubMed · 2025 · Journal Article
- The neuroprotective role of riluzole in spinal cord injury: a systematic review and meta-analysis. — PubMed · 2025 · Journal Article
- Neuroprotective Riluzole-Releasing Electrospun Implants for Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Therapeutic strategies that modulate the acute phase of secondary spinal cord injury scarring and inflammation and improve injury outcomes. — PubMed · 2025 · Journal Article
- Pharmacologic Therapy for Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Pharmacological management of secondary chronic spinal cord injury: a systematic review. — PubMed · 2024 · Journal Article
- Critical Care of Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Spinal cord injury in high-risk complex adult spinal deformity surgery: review of incidence and outcomes from the Scoli-RISK-1 study. — PubMed · 2024 · Journal Article
- Functional Polyphenol-Based Nanoparticles Boosted the Neuroprotective Effect of Riluzole for Acute Spinal Cord Injury. — PubMed · 2024 · Journal Article
- An updated systematic review of neuroprotective agents in the treatment of spinal cord injury. — PubMed · 2024 · Systematic Review
- An Introduction to the North American Clinical Trials Network for Spinal Cord Injury Special Edition: Reflections on Accomplishments and a Look to the Future. — PubMed · 2023 · Journal Article
- Riluzole in Spinal Cord Injury Study (RISCIS)-Pharmacokinetic (PK) Sub-Study: An Analysis of Pharmacokinetics, Pharmacodynamics, and Impact on Axonal Degradation of Riluzole in Patients With Traumatic Cervical Spinal Cord Injury Enrolled in the RISCIS Phase III Randomized Controlled Trial. — PubMed · 2023 · Randomized Controlled Trial
- Safety and Efficacy of Riluzole in Acute Spinal Cord Injury Study (RISCIS): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial. — PubMed · 2023 · Randomized Controlled Trial
- Riluzole for treating spasticity in patients with chronic traumatic spinal cord injury: Study protocol in the phase ib/iib adaptive multicenter randomized controlled RILUSCI trial. — PubMed · 2023 · Clinical Trial Protocol
- Isolated pulmonary recovery in a veteran with late stage bulbar ALS following edaravone treatment and cessation. — PubMed · 2022 · Case Reports
- Riluzole Promotes Neurite Growth in Rats after Spinal Cord Injury through the GSK-3β/CRMP-2 Pathway. — PubMed · 2022 · Journal Article
- Corticospinal Motor Circuit Plasticity After Spinal Cord Injury: Harnessing Neuroplasticity to Improve Functional Outcomes. — PubMed · 2021 · Journal Article
- Longitudinal Impact of Acute Spinal Cord Injury on Clinical Pharmacokinetics of Riluzole, a Potential Neuroprotective Agent. — PubMed · 2021 · Clinical Trial, Phase II
- Pharmacologic and Cell-Based Therapies for Acute Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial. — PubMed · 2021 · Clinical Trial, Phase Iii
- Neuroprotective effects of Riluzole and Curcumin in human astrocytes and spinal cord white matter hypoxia. — PubMed · 2020 · Journal Article
- The Treatment of Perioperative Spinal Cord Injury With Hyperbaric Oxygen Therapy: A Case Report. — PubMed · 2020 · Case Reports
- Degenerative Cervical Myelopathy: Changing Frontiers. — PubMed · 2020 · Journal Article
- Does Riluzole Influence Bone Formation?: An In Vitro Study of Human Mesenchymal Stromal Cells and Osteoblast. — PubMed · 2019 · Journal Article
- Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition — ClinicalTrials.gov · 2019 · Interventional · Unknown
- Time is spine: a review of translational advances in spinal cord injury. — PubMed · 2018 · Journal Article
- UPLC-MS/MS assay of riluzole in human plasma and cerebrospinal fluid (CSF): Application in samples from spinal cord injured patients. — PubMed · 2017 · Journal Article
- Assessment and management of acute spinal cord injury: From point of injury to rehabilitation. — PubMed · 2017 · Case Reports
- Traumatic Spinal Cord Injury-Repair and Regeneration. — PubMed · 2017 · Journal Article
- Predicting Recruitment Feasibility for Acute Spinal Cord Injury Clinical Trials in Canada Using National Registry Data. — PubMed · 2017 · Journal Article
- A review and update on the current and emerging clinical trials for the acute management of cervical spine and spinal cord injuries - Part III. — PubMed · 2016 · Journal Article
- Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury. — PubMed · 2016 · Journal Article
- Cleavage of Na(+) channels by calpain increases persistent Na(+) current and promotes spasticity after spinal cord injury. — PubMed · 2016 · Journal Article
- Mediating the Secondary Effects of Spinal Cord Injury Through Optimization of Key Physiologic Parameters. — PubMed · 2016 · Journal Article
- Acute Spinal Cord Injury. — PubMed · 2015 · Journal Article
- Investigational drugs for the treatment of spinal cord injury: review of preclinical studies and evaluation of clinical trials from Phase I to II. — PubMed · 2015 · Journal Article
- Recent advances in the pharmacologic treatment of spinal cord injury. — PubMed · 2015 · Journal Article
- Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury. — PubMed · 2015 · Journal Article
- A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury. — PubMed · 2014 · Clinical Trial, Phase I
- Riluzole in Spinal Cord Injury Study — ClinicalTrials.gov · 2013 · Interventional · Terminated
- Emerging therapies for acute traumatic spinal cord injury. — PubMed · 2013 · Journal Article
- Riluzole: what it does to spinal and brainstem neurons and how it does it. — PubMed · 2013 · Journal Article
- Multicenter clinical research networks for traumatic spinal cord injury: a critical pathway to discovery. — PubMed · 2012 · Editorial
- North American Clinical Trials Network for the Treatment of Spinal Cord Injury: goals and progress. — PubMed · 2012 · Journal Article
- Pharmacology of riluzole in acute spinal cord injury. — PubMed · 2012 · Clinical Trial, Phase I
- Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial. — PubMed · 2012 · Clinical Trial, Phase I
- Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury. — PubMed · 2012 · Journal Article
- Limiting spinal cord injury by pharmacological intervention. — PubMed · 2012 · Journal Article
- A systematic review of directly applied biologic therapies for acute spinal cord injury. — PubMed · 2011 · Journal Article
- A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. — PubMed · 2011 · Journal Article
- Riluzole decreases flexion withdrawal reflex but not voluntary ankle torque in human chronic spinal cord injury. — PubMed · 2011 · Journal Article
- Spinal cord injury: a systematic review of current treatment options. — PubMed · 2011 · Journal Article
- Emerging repair, regeneration, and translational research advances for spinal cord injury. — PubMed · 2010 · Journal Article
- Safety of Riluzole in Patients With Acute Spinal Cord Injury — ClinicalTrials.gov · 2010 · Observational · Completed
- Impact of Persistent Conductances on Motor Unit Firing in SCI — ClinicalTrials.gov · 2009 · Interventional · Unknown
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 4 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 810282 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 132 · this programme has 132 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("riluzole") - Crossref
spinal cord injury riluzole - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Riluzole"[MeSH Terms] OR "riluzole"[Title/Abstract])