A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
The source has not said who or what was studied
- Blockage of ERCC6 Alleviates Spinal Cord Injury Through Weakening Apoptosis, Inflammation, Senescence, and Oxidative Stress. — PubMed · 2022 · Journal Article
- MicroRNA miR-155 Activity in Mouse Choline Acetyltransferase-Positive Neurons Is Critical for the Rate of Early and Late Paraplegia After Transient Aortic Cross-Clamping. — PubMed · 2022 · Journal Article
- Downregulation of MicroRNA-145-5p in Activated Microglial Exosomes Promotes Astrocyte Proliferation by Removal of Smad3 Inhibition. — PubMed · 2022 · Journal Article
- Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway. — PubMed · 2022 · Journal Article
- Spinal cord injury pain: A retrospective — Crossref · 2022 · book-chapter
- The decreased expression of miR-429 in plasma exosomes after spinal cord injury inhibits neuronal apoptosis by mediating the PTEN/PI3K/Akt pathway. — PubMed · 2022 · Journal Article
- WITHDRAWN: Role of microRNA-19b-3p on osteoporosis after experimental spinal cord injury in rats. — PubMed · 2021 · Journal Article The source marks this record as retracted.
- Neural Stem Cells Overexpressing Nerve Growth Factor Improve Functional Recovery in Rats Following Spinal Cord Injury via Modulating Microenvironment and Enhancing Endogenous Neurogenesis. — PubMed · 2021 · Journal Article
- MicroRNA-218 aggravates H(2)O(2)-induced damage in PC12 cells via spred2-mediated autophagy. — PubMed · 2021 · Journal Article
- Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury. — PubMed · 2021 · Journal Article
- Long Non-coding RNAs and Circular RNAs: Insights Into Microglia and Astrocyte Mediated Neurological Diseases. — PubMed · 2021 · Journal Article
- Fascin-1 is Highly Expressed Specifically in Microglia After Spinal Cord Injury and Regulates Microglial Migration. — PubMed · 2021 · Journal Article
- hsa-MiR-19a-3p and hsa-MiR-19b-3p Are Associated with Spinal Cord Injury-Induced Neuropathic Pain: Findings from a Genome-Wide MicroRNA Expression Profiling Screen. — PubMed · 2021 · Journal Article
- miR-153 attenuates the inflammatory response and oxidative stress induced by spinal cord injury by targeting of NEUROD2. — PubMed · 2021 · Journal Article
- Silencing of Long Noncoding RNA Growth Arrest-Specific 5 Alleviates Neuronal Cell Apoptosis and Inflammatory Responses Through Sponging microRNA-93 to Repress PTEN Expression in Spinal Cord Injury. — PubMed · 2021 · Journal Article
- microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury. — PubMed · 2021 · Journal Article
- Extracellular vesicles derived from mesenchymal stem cells containing microRNA-381 protect against spinal cord injury in a rat model via the BRD4/WNT5A axis. — PubMed · 2021 · Journal Article
- Knockdown of lncRNA SNHG14 alleviates LPS-induced inflammation and apoptosis of PC12 cells by regulating miR-181b-5p. — PubMed · 2021 · Journal Article
- Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain. — PubMed · 2021 · Journal Article
- LncRNA Airsci increases the inflammatory response after spinal cord injury in rats through the nuclear factor kappa B signaling pathway. — PubMed · 2021 · Journal Article
- Mettl14-mediated m6A modification modulates neuron apoptosis during the repair of spinal cord injury by regulating the transformation from pri-mir-375 to miR-375. — PubMed · 2021 · Journal Article
- MiR-495 regulates cell proliferation and apoptosis in H(2)O(2) stimulated rat spinal cord neurons through targeting signal transducer and activator of transcription 3 (STAT3). — PubMed · 2021 · Journal Article
- Catalpol Protects Against Spinal Cord Injury in Mice Through Regulating MicroRNA-142-Mediated HMGB1/TLR4/NF-κB Signaling Pathway. — PubMed · 2021 · Journal Article
- Roles of Non-coding RNAs in Central Nervous System Axon Regeneration. — PubMed · 2021 · Journal Article
- Mir21 modulates inflammation and sensorimotor deficits in cervical myelopathy: data from humans and animal models. — PubMed · 2021 · Journal Article
- UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration. — PubMed · 2020 · Journal Article
- Corrigendum: Comparative proteomes change and possible role in different pathways of microRNA-21a-5p in a mouse model of spinal cord injury. — PubMed · 2020 · Journal Article
- Irisin Protects Against Motor Dysfunction of Rats with Spinal Cord Injury via Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase-Nuclear Factor Kappa-B Pathway. — PubMed · 2020 · Journal Article
- MicroRNA regulatory pattern in spinal cord ischemia-reperfusion injury. — PubMed · 2020 · Journal Article
- MicroRNA-135a-5p Promotes the Functional Recovery of Spinal Cord Injury by Targeting SP1 and ROCK. — PubMed · 2020 · Journal Article
- Decoding epigenetic codes: new frontiers in exploring recovery from spinal cord injury. — PubMed · 2020 · Journal Article
- ADNCR modulates neural stem cell differentiation and proliferation through the regulation of TCF3 expression. — PubMed · 2020 · Journal Article
- MicroRNA expression profile in the spinal cord injured rat neurogenic bladder by next-generation sequencing. — PubMed · 2020 · Journal Article
- Exosome-Mediated siRNA pool Inhibits Axonal Growth Inhibitor in Cortical Neurons of Spinal Cord Injury in Rats — Crossref · 2020 · posted-content
- MicroRNA-124 Overexpression in Schwann Cells Promotes Schwann Cell-Astrocyte Integration and Inhibits Glial Scar Formation Ability. — PubMed · 2020 · Journal Article
- MicroRNA-466c-3p exerts protective effect on neuronal apoptosis and improves functional recovery post spinal cord injury via mitochondrial apoptotic pathway. — PubMed · 2020 · Journal Article
- Comparative proteomes change and possible role in different pathways of microRNA-21a-5p in a mouse model of spinal cord injury. — PubMed · 2020 · Journal Article
- Up-regulation of MicroRNAs-21 and -223 in a Sprague-Dawley Rat Model of Traumatic Spinal Cord Injury. — PubMed · 2020 · Journal Article
- The Role of Neuronal Factors in the Epigenetic Reprogramming of Microglia in the Normal and Diseased Central Nervous System. — PubMed · 2019 · Journal Article
- Silencing of the MEKK2/MEKK3 Pathway Protects against Spinal Cord Injury via the Hedgehog Pathway and the JNK Pathway. — PubMed · 2019 · Journal Article The source marks this record as retracted.
- MicroRNA-31 regulating apoptosis by mediating the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in treatment of spinal cord injury. — PubMed · 2019 · Journal Article
- The Value of MicroRNAs as an Indicator of the Severity and the Acute Phase of Spinal Cord Injury. — PubMed · 2019 · Journal Article
- MicroRNAs in Microglia: How do MicroRNAs Affect Activation, Inflammation, Polarization of Microglia and Mediate the Interaction Between Microglia and Glioma? — PubMed · 2019 · Journal Article
- miR-34a alleviates spinal cord injury via TLR4 signaling by inhibiting HMGB-1. — PubMed · 2019 · Journal Article
- Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration. — PubMed · 2019 · Journal Article
- Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury. — PubMed · 2019 · Journal Article
- MicroRNA-23b attenuates the H(2)O(2)-induced injury of microglial cells via TAB3/NF-κB signaling pathway. — PubMed · 2018 · Journal Article
- miRNA-146a attenuates inflammation in an in vitro spinal cord injury model via inhibition of TLR4 signaling. — PubMed · 2018 · Journal Article
- microRNA-182-5p alleviates spinal cord injury by inhibiting inflammation and apoptosis through modulating the TLR4/NF-κB pathway. — PubMed · 2018 · Journal Article
- Protective role of microRNA-219-5p inhibitor against spinal cord injury via liver receptor homolog-1/Wnt/β-catenin signaling pathway regulation. — PubMed · 2018 · Journal Article
- RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity. — PubMed · 2018 · Journal Article
- Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury. — PubMed · 2018 · Journal Article
- Activation of AMPK by OSU53 protects spinal cord neurons from oxidative stress. — PubMed · 2017 · Journal Article
- Nischarin-siRNA delivered by polyethylenimine-alginate nanoparticles accelerates motor function recovery after spinal cord injury. — PubMed · 2017 · Journal Article
- Liraglutide activates autophagy via GLP-1R to improve functional recovery after spinal cord injury. — PubMed · 2017 · Journal Article
- MicroRNA-223 alleviates lipopolysaccharide-induced PC-12 cells apoptosis and autophagy by targeting RPH1 in spinal cord injury. — PubMed · 2017 · Journal Article
- The inhibition of microRNA-31 weakens acute spinal cord injury through nuclear factor-κB and TGF-β/Smad 2 in rat. — PubMed · 2017 · Journal Article
- Ferulic Acid Improves Functional Recovery after Acute Spinal Cord Injury in Rats by Inducing Hypoxia to Inhibit microRNA-590 and Elevate Vascular Endothelial Growth Factor Expressions. — PubMed · 2017 · Journal Article
- MicroRNAs as Important Regulators of Exercise Adaptation. — PubMed · 2017 · Journal Article
- Targeted siRNA delivery reduces nitric oxide mediated cell death after spinal cord injury — Crossref · 2017 · journal-article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])