A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as laboratory work
- [Netrin-1 and stem cells, attraction or repulsion?]. — PubMed · 2010 · News
- Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration. — PubMed · 2007 · Journal Article
The source has not said who or what was studied
- Therapeutic potential of astrocyte transdifferentiated neurons. — PubMed · 2026 · Journal Article
- Editorial: Exploring miRNA roles in neuroinflammation and brain aging: mechanisms and therapeutic potential. — PubMed · 2026 · Editorial
- ID3 -depleted human induced pluripotent stem cell-derived neural stem/progenitor cells promote neurorepair. — PubMed · 2026 · Journal Article
- D-dopachrome tautomerase promotes astrocytic cholesterol 25-hydroxylase expression through the ERK/NF-κB pathway following rat spinal cord injury. — PubMed · 2026 · Journal Article
- Interfering with PTBP1 expression promotes anti-inflammatory macrophage polarization alongside altered activity of the miR-124/p38MAPK pathway. — PubMed · 2026 · Journal Article
- Integrative bulk and single-cell transcriptome analyses reveal RNA modification-related biomarkers of spinal cord injury. — PubMed · 2026 · Journal Article
- Cross-Species Transcriptomic Analysis Identifies an Endocannabinoid-Associated Immune Remodeling Signature and Candidate Pharmacologic Targets in Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Spinal cord transverse section hinders Wallerian degeneration and neoangiogenesis after peripheral nerve transection: Involvement of Schwann cells' miR-134-5p. — PubMed · 2026 · Journal Article
- Inhibition of Sirpα expression enhances microglial phagocytic clearance of myelin debris and reduces neuronal PANoptosis after spinal cord injury. — PubMed · 2026 · Journal Article
- Development of a PTEN-siRNA activated scaffold to promote axonal regrowth following spinal cord injury. — PubMed · 2026 · Journal Article
- The potential mechanisms and regulatory roles of exosomal miRNA in neural repair after spinal cord injury. — PubMed · 2026 · Journal Article
- Spatiotemporal delivery of multifunctional nanozymes for neuroinflammation alleviation via autophagy modulation in spinal cord injury. — PubMed · 2025 · Journal Article
- Axonal Regeneration, Growth Cone, and the FIGN Gene Family: A Comprehensive Review. — PubMed · 2025 · Journal Article
- Decoding the ceRNA regulatory landscape: a comprehensive transcriptomic analysis of ncRNA-driven bladder fibrosis following spinal cord injury. — PubMed · 2025 · Journal Article
- Integrated multi-omics profiling uncovers miRNA-guided regulatory networks after spinal cord injury in rats. — PubMed · 2025 · Journal Article
- Importance of ultradian oscillations in neurogenesis during development and its implications for spinal cord regeneration. — PubMed · 2025 · Journal Article
- Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury. — PubMed · 2025 · Journal Article
- NcRNAs: a potential treatment for spinal cord injury. — PubMed · 2025 · Journal Article
- Inhibition of miR-20a promotes neural stem cell survival under oxidative stress conditions. — PubMed · 2025 · Journal Article
- Usp18 Mediates D-Dopachrome Tautomerase-Induced Astrocytic Inflammation After Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Long non-coding RNA GAS5 promotes neuronal apoptosis in spinal cord injury via the miR-21/PTEN axis. — PubMed · 2025 · Journal Article
- Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model. — PubMed · 2025 · Journal Article
- Controlled release of MIF siRNA and GDNF protein from a photocurable scaffold efficiently repairs spinal cord injury. — PubMed · 2025 · Journal Article
- The Therapeutic Potential of MicroRNA-21 in the Treatment of Spinal Cord Injury. — PubMed · 2025 · Journal Article
- MicroRNA-219 in the central nervous system: a potential theranostic approach. — PubMed · 2024 · Journal Article
- Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning. — PubMed · 2024 · Journal Article
- Small extracellular vesicles from hypoxia-preconditioned bone marrow mesenchymal stem cells attenuate spinal cord injury via miR-146a-5p-mediated regulation of macrophage polarization. — PubMed · 2024 · Journal Article
- LncRNA OIP5-AS1 regulates ferroptosis and mitochondrial dysfunction-mediated apoptosis in spinal cord injury by targeting the miR-128-3p/Nrf2 axis. — PubMed · 2024 · Journal Article
- Spinal Cord Injury Management Based on Microglia-Targeting Therapies. — PubMed · 2024 · Journal Article
- The role of small extracellular vesicles and microRNA as their cargo in the spinal cord injury pathophysiology and therapy. — PubMed · 2024 · Journal Article
- Uncovering the shared neuro-immune-related regulatory mechanisms between spinal cord injury and osteoarthritis. — PubMed · 2024 · Journal Article
- Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derived C9orf72-associated ALS/FTD motor neurons. — PubMed · 2024 · Preprint
- Role of CD36 in central nervous system diseases. — PubMed · 2024 · Journal Article
- The Reduction of Traumatic Spinal Cord Secondary Injury by Anti-RhoA siRNA Functionalized Nucleic Acid Nanoparticles (NANPs). — PubMed · 2024 · Journal Article
- Circular RNA HIPK2 Promotes A1 Astrocyte Activation after Spinal Cord Injury through Autophagy and Endoplasmic Reticulum Stress by Modulating miR-124-3p-Mediated Smad2 Repression. — PubMed · 2023 · Journal Article
- Axon guidance gene-targeted siRNA delivery system improves neural stem cell transplantation therapy after spinal cord injury. — PubMed · 2023 · Journal Article
- Bone marrow mesenchymal stem cell exosomes-derived microRNA-216a-5p on locomotor performance, neuronal injury, and microglia inflammation in spinal cord injury. — PubMed · 2023 · Journal Article
- Inhibiting tau protein improves the recovery of spinal cord injury in rats by alleviating neuroinflammation and oxidative stress. — PubMed · 2023 · Journal Article
- Suppression of Fibroblast Growth Factor Receptor-5 (FGFR5) has no Impact on Axon Regeneration after SCI. — PubMed · 2023 · Journal Article
- Inhibition of miR-221-3p promotes axonal regeneration and repair of primary sensory neurons via regulating p27 expression. — PubMed · 2023 · Journal Article
- Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury. — PubMed · 2023 · Journal Article
- Age-related changes in plasma extracellular vesicles influence neuroinflammation in the brain and neurological outcome after traumatic spinal cord injury. — PubMed · 2023 · Preprint
- MicroRNAs in spinal cord injury: A narrative review. — PubMed · 2023 · Journal Article
- MicroRNA-mediated regulation of reactive astrocytes in central nervous system diseases. — PubMed · 2023 · Journal Article
- Relationship between the therapeutic potential of various plant-derived bioactive compounds and their related microRNAs in neurological disorders. — PubMed · 2023 · Journal Article
- Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury. — PubMed · 2022 · Journal Article
- The emerging power and promise of non-coding RNAs in chronic pain. — PubMed · 2022 · Journal Article
- Astragaloside IV ameliorates spinal cord injury through controlling ferroptosis in H(2)O(2)-damaged PC12 cells in vitro. — PubMed · 2022 · Journal Article
- Exosomes derived from M2 Macrophages Improve Angiogenesis and Functional Recovery after Spinal Cord Injury through HIF-1α/VEGF Axis. — PubMed · 2022 · Journal Article
- A variant in microRNA-124 is involved in the control of neural cell apoptosis and associated with recovery after spinal cord injury (SCI). — PubMed · 2022 · Journal Article
- Transplantation of IGF-1-induced BMSC-derived NPCs promotes tissue repair and motor recovery in a rat spinal cord injury model. — PubMed · 2022 · Journal Article
- Mesenchymal Stem Cell-Derived Exosomal MiRNAs Promote M2 Macrophages Polarization: Therapeutic Opportunities for Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Neuronal reprogramming in treating spinal cord injury. — PubMed · 2022 · Journal Article
- MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord. — PubMed · 2022 · Journal Article
- DJ-1 Alleviates Neuroinflammation and the Related Blood-Spinal Cord Barrier Destruction by Suppressing NLRP3 Inflammasome Activation via SOCS1/Rac1/ROS Pathway in a Rat Model of Traumatic Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Micro-RNA let-7a-5p Derived From Mesenchymal Stem Cell-Derived Extracellular Vesicles Promotes the Regrowth of Neurons in Spinal-Cord-Injured Rats by Targeting the HMGA2/SMAD2 Axis. — PubMed · 2022 · Journal Article
- Circular RNA in Acute Central Nervous System Injuries: A New Target for Therapeutic Intervention. — PubMed · 2022 · Journal Article
- Drug Discovery in Spinal Cord Injury With Ankylosing Spondylitis Identified by Text Mining and Biomedical Databases. — PubMed · 2022 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])