A subject this map covers
Gene therapy
What belongs here
Introducing, silencing or editing a gene in nervous-system cells after injury.
What does not belong here, however close it looks
Cells engineered in a dish and then transplanted also belong to cell therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 185 records · 1992–2026
- Indexed as work in animals: 221 records · 1994–2026
- Indexed as laboratory work: 18 records · 1997–2021
- The source has not said who or what was studied: 99 records · 1997–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
523 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Treatment of spinal injury muscle spasticity by spinal subpial AAV9-GAD65/VGAT delivery: An efficacy and safety study in rat, pig, and NHP. — PubMed · 2026 · Journal Article
- Beyond Scar Removal: Reprogramming the Glial Scar for Neural Repair. — PubMed · 2026 · Journal Article
- Research Progress on Regulating Neuroinflammation After Spinal Cord Injury by Targeting the cGAS-STING Pathway. — PubMed · 2026 · Journal Article
- Advances in tailored intraparenchymal delivery of regenerative medicine for spinal cord injury: a review of preclinical studies and clinical trials. — PubMed · 2026 · Journal Article
- [Research advances in nerve transfer for upper limb function restoration: applications from peripheral nerve injury to central nervous system injury]. — PubMed · 2026 · Journal Article
- Long-term Follow-up Study of Patients Who Received EG110A, a Non-replicative Herpes Simplex Virus 1-derived Gene Therapy — ClinicalTrials.gov · 2026 · Interventional · Not Yet Recruiting
- AAV vectors: an emerging strategy for chronic pain management. — PubMed · 2026 · Journal Article
- Ferroptosis-associated transcriptional factors in neurological diseases: molecular mechanisms and therapeutic prospects. — PubMed · 2025 · Journal Article
- Injectable approaches to deliver innovative treatments for spinal cord: When regenerative medicine meets precision medicine. — PubMed · 2025 · Journal Article
- RNA Interference and Its Key Targets for Spinal Cord Injury Therapy: What Is Known So Far? — PubMed · 2025 · Journal Article
- Exosomes-Based Nanotherapeutic Strategies: An Important Approach for Spinal Cord Injury Repair. — PubMed · 2025 · Journal Article
- First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury — ClinicalTrials.gov · 2025 · Interventional · Recruiting
- Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation. — PubMed · 2025 · Journal Article
- Present insights into the progress in gene therapy delivery systems for central nervous system diseases. — PubMed · 2025 · Journal Article
- Exosomal MiRNA Therapy for Central Nervous System Injury Diseases. — PubMed · 2024 · Journal Article
- Neuropathic Pain Induced by Spinal Cord Injury from the Glia Perspective and Its Treatment. — PubMed · 2024 · Journal Article
- Regenerative medicine for spinal cord injury using induced pluripotent stem cells: from animals to humans. — PubMed · 2024 · Journal Article
- 1953-2023. Seventy Years of the Nerve Growth Factor: A Potential Novel Treatment in Neurological Diseases? — PubMed · 2024 · Journal Article
- Enhancing regenerative potential: A comprehensive review of stem cell transplantation for sports-related neuronal injuries, with a focus on spinal cord injuries and peripheral nervous system damage. — PubMed · 2024 · Journal Article
- Gut microbiota and traumatic central nervous system injuries: Insights into pathophysiology and therapeutic approaches. — PubMed · 2023 · Journal Article
- PTEN knockout using retrogradely transported AAVs transiently restores locomotor abilities in both acute and chronic spinal cord injury. — PubMed · 2023 · Journal Article
- Applications of chitosan-based biomaterials: From preparation to spinal cord injury neuroprosthetic treatment. — PubMed · 2023 · Journal Article
- Stem cell and tissue engineering approaches in pressure ulcer treatment. — PubMed · 2023 · Journal Article
- Synaptogenic gene therapy with FGF22 improves circuit plasticity and functional recovery following spinal cord injury. — PubMed · 2023 · Journal Article
- Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors. — PubMed · 2023 · Journal Article
- Neural Stem Cells Overexpressing Arginine Decarboxylase Improve Functional Recovery from Spinal Cord Injury in a Mouse Model. — PubMed · 2022 · Journal Article
- Transplantation of neural progenitor cells into the human CNS. — PubMed · 2022 · Journal Article
- Stem cell-based therapy for human diseases. — PubMed · 2022 · Journal Article
- The use of viral vectors to promote repair after spinal cord injury. — PubMed · 2022 · Journal Article
- Advances in chondroitinase delivery for spinal cord repair. — PubMed · 2022 · Journal Article
- Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury. — PubMed · 2022 · Journal Article
- Peripherally delivered Adeno-associated viral vectors for spinal cord injury repair. — PubMed · 2022 · Journal Article
- Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases. — PubMed · 2022 · Journal Article
- LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury. — PubMed · 2021 · Journal Article
- The potential roles of circular RNAs as modulators in traumatic spinal cord injury. — PubMed · 2021 · Journal Article
- Regenerative medicine for neurological diseases-will regenerative neurosurgery deliver? — PubMed · 2021 · Journal Article
- Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice. — PubMed · 2021 · Journal Article
- Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment. — PubMed · 2020 · Journal Article
- [Inhibitory effect of miR-429 on expressions of ZO-1, Occludin, and Claudin-5 proteins to improve the permeability of blood spinal cord barrier in vitro]. — PubMed · 2020 · Journal Article
- Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing. — PubMed · 2020 · Journal Article
- Upregulation of microRNA-200a in bone marrow mesenchymal stem cells enhances the repair of spinal cord injury in rats by reducing oxidative stress and regulating Keap1/Nrf2 pathway. — PubMed · 2020 · Journal Article
- Novel innovations in cell and gene therapies for spinal cord injury. — PubMed · 2020 · Journal Article
- CRISPR, Prime Editing, Optogenetics, and DREADDs: New Therapeutic Approaches Provided by Emerging Technologies in the Treatment of Spinal Cord Injury. — PubMed · 2020 · Journal Article
- Viral Vector-Mediated Gene Transfer of Glutamic Acid Decarboxylase for Chronic Pain Treatment: A Literature Review. — PubMed · 2020 · Journal Article
- Degenerative Cervical Myelopathy: Changing Frontiers. — PubMed · 2020 · Journal Article
- Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions. — PubMed · 2020 · Journal Article
- Recent advances in the therapeutic uses of chondroitinase ABC. — PubMed · 2019 · Journal Article
- Scaffold-mediated sequential drug/gene delivery to promote nerve regeneration and remyelination following traumatic nerve injuries. — PubMed · 2019 · Journal Article
- The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury. — PubMed · 2019 · Journal Article
- Biomaterials and Gene Manipulation in Stem Cell-Based Therapies for Spinal Cord Injury. — PubMed · 2019 · Journal Article
- HIF-1α promotes bone marrow stromal cell migration to the injury site and enhances functional recovery after spinal cord injury in rats. — PubMed · 2018 · Journal Article
- Effective control of neuropathic pain by transient expression of hepatocyte growth factor in a mouse chronic constriction injury model. — PubMed · 2018 · Journal Article
- Non-viral-mediated suppression of AMIGO3 promotes disinhibited NT3-mediated regeneration of spinal cord dorsal column axons. — PubMed · 2018 · Journal Article
- Characterization of neural stem cells modified with hypoxia/neuron-specific VEGF expression system for spinal cord injury. — PubMed · 2018 · Journal Article
- Transplantation of BDNF Gene Recombinant Mesenchymal Stem Cells and Adhesive Peptide-modified Hydrogel Scaffold for Spinal Cord Repair. — PubMed · 2018 · Journal Article
- Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model. — PubMed · 2017 · Journal Article
- Trafficking and processing of bacterial proteins by mammalian cells: Insights from chondroitinase ABC. — PubMed · 2017 · Journal Article
- The enigma of stem cell-based therapies - how to conquer the death valley of therapy development. — PubMed · 2017 · Editorial
- Lentiviral Delivery of miR-133b Improves Functional Recovery After Spinal Cord Injury in Mice. — PubMed · 2017 · Journal Article
- Post-spinal cord injury astrocyte-mediated functional recovery in rats after intraspinal injection of the recombinant adenoviral vectors Ad5-VEGF and Ad5-ANG. — PubMed · 2017 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 3660371 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 1 · this programme has 495 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("gene therapy" OR "gene delivery") - Crossref
spinal cord injury gene therapy gene delivery - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Genetic Therapy"[MeSH Terms] OR "gene therapy"[Title/Abstract] OR "gene delivery"[Title/Abstract])