A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. — PubMed · 2013 · Journal Article
- Rejuvenating nerve cells in adults. — PubMed · 2013 · Editorial
- The emerging roles of microRNAs in CNS injuries. — PubMed · 2013 · Journal Article
- The use of connexin-based therapeutic approaches to target inflammatory diseases. — PubMed · 2013 · Journal Article
- microRNA-21 regulates astrocytic response following spinal cord injury. — PubMed · 2012 · Journal Article
- MicroRNAs: a light into the "black box" of neuropediatric diseases? — PubMed · 2012 · Journal Article
- Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord. — PubMed · 2012 · Journal Article
- Inhibition of Nogo expression to promote repair after spinal cord injury. — PubMed · 2012 · Journal Article
- Silencing of miR20a is crucial for Ngn1-mediated neuroprotection in injured spinal cord. — PubMed · 2012 · Journal Article
- [Specific expression of microRNA in different tissues of nervous system and expression changes in nerve regeneration]. — PubMed · 2011 · English Abstract
- The extracellular matrix glycoprotein tenascin-C promotes locomotor recovery after spinal cord injury in adult zebrafish. — PubMed · 2011 · Journal Article
- Biochanin A reduces drug-induced p75NTR expression and enhances cell survival: a new in vitro assay for screening inhibitors of p75NTR expression. — PubMed · 2010 · Journal Article
- MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. — PubMed · 2010 · Comparative Study
- MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. — PubMed · 2010 · Journal Article
- Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling. — PubMed · 2010 · Journal Article
- Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line. — PubMed · 2008 · Journal Article
- Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. — PubMed · 2008 · Journal Article
- LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin. — PubMed · 2008 · Journal Article
- Genetic modification of stem cells for transplantation. — PubMed · 2008 · Journal Article
- p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action. — PubMed · 2007 · Journal Article
- Embryonic stem cells: from bench to bedside. — PubMed · 2007 · Journal Article
- A molecular biological approach to neuropathy of the urinary bladder/prostate in patients with spinal cord injury. — PubMed · 1997 · Letter
Indexed as work in animals
- Amniotic fluid stem cells alleviate neuronal injury-related changes in spina bifida by inducing autophagy via regulating the FOXO1/STAT3 axis. — PubMed · 2026 · Journal Article
- Lgals3(high) macrophages orchestrate neuroinflammation and extracellular matrix remodelling via NF-κB pathway in acute spinal cord injury. — PubMed · 2026 · Journal Article
- MiR-425-5p modulation of CREB1 affects inflammatory response and motor recovery after spinal cord injury. — PubMed · 2026 · Journal Article
- [Modified Shaoyao Gancao decoction()alleviates post-spinal cord injury muscle spasticity by regulating the lncRNA H19/miR-185-5p/Tph1 axis]. — PubMed · 2026 · English Abstract
- Astrocyte-derived exosome-mediated siRNA delivery combined with quercetin-Mn complex promotes neural repair in spinal cord injury. — PubMed · 2026 · Journal Article
- Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Piezo1 promote macrophage-to-myofibroblast transition and bladder fibrosis in neurogenic bladder. — PubMed · 2026 · Journal Article
- [Regulation of the IL-6 and IL-16 pathway in spinal cord tissue by plasma exosome-mediated miR-125b-5p in a rat model of spinal cord injury]. — PubMed · 2026 · English Abstract
- miR-19a-3p and miR-19b-3p Promote Microglia Activation Associated With Neuroinflammation. — PubMed · 2026 · Journal Article
- Silencing Adamts2 attenuates fibroblast-mediated fibrosis and promotes axonal regeneration in an in vitro model. — PubMed · 2026 · Journal Article
- Body weight-supported treadmill training enhances motor recovery and ameliorates neuron injury through the MDK/LRP-1 signaling pathway in T10 incomplete spinal cord-injured rats. — PubMed · 2026 · Journal Article
- Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after spinal cord injury. — PubMed · 2026 · Journal Article
- LEP Knockdown Improves Functional Recovery After Spinal Cord Injury and Potentially Regulates Microglial Polarization via JAK-STAT Signaling Pathway. — PubMed · 2026 · Journal Article
- Dose and parameter specific effects of curcumin on neuropathic pain, cavity formation, and non-coding RNA expression in a spinal cord injury model. — PubMed · 2026 · Journal Article
- Sortilin is Associated with PGRN-Mediated Endoplasmic Reticulum Stress and Activation of Microglia in a Rat Model of Degenerative Cervical Myelopathy. — PubMed · 2026 · Journal Article
- miR-24-3p promotes spinal cord injury repair in rats by inhibiting ferroptosis via targeting GSK-3β. — PubMed · 2026 · Journal Article
- Inflachromene Blocks Neuronal HMGB1 Translocation to Mitigate Hippocampal TLR4-NF-κB-Mediated Neuroinflammation and Depression-Like Behavior After Spinal Cord Injury. — PubMed · 2026 · Journal Article
- circ_0044235 exacerbates neuroinflammation and apoptosis following spinal cord injury by targeting miR-338-5p. — PubMed · 2026 · Journal Article
- Targeting miR-499-5p for neuroprotection in spinal cord injury: Implications for inflammation and ROS-induced neuronal damage. — PubMed · 2026 · Journal Article
- Neural Stem Cell-Derived Exosomes-Transmitted miR-31-5p Promote Functional Recovery of Spinal Cord Injury by Shifting Astrocytes A1/A2 Polarization. — PubMed · 2026 · Journal Article
- Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-responsive brown adipose tissue for targeted neuroinflammation modulation. — PubMed · 2026 · Journal Article
- LPS Pre-Conditioned Olfactory Ensheathing Cells Derived Extracellular Vesicle Regulate Microglia Polarization Through mir-1224/CD44/SLC7A11 Axis Following Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Morusin Alleviates Spinal Cord Injury in Rats by Regulating Macrophage Reprogramming Through Targeting RELA and NRF2. — PubMed · 2026 · Journal Article
- Serotonergic System-Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy. — PubMed · 2026 · Journal Article
- Sustained MicroRNA delivery enhanced remyelination and functional recovery after spinal cord injury. — PubMed · 2026 · Journal Article
- Hypoxia-conditioned BMSC exosomes improve short-term spinal cord injury outcomes via the miR-615-3p/PDE4C-mediated cAMP/PKA pathway. — PubMed · 2026 · Journal Article
- Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1-Mediated Mechanotransduction. — PubMed · 2026 · Journal Article
- Silencing miR-134-5p promotes functional recovery after spinal cord injury by activating brain-derived neurotrophic factor (BDNF). — PubMed · 2026 · Journal Article
- MiR499-5P loaded MSC derived exosomes affect oxidative stress and inflammatory response after spinal cord injury by targeting genes. — PubMed · 2025 · Journal Article
- Engineered BMSC-derived exosomes deliver miR-17-5p inhibitor to restore sensory conduction via the IL-11/GP130/STAT3/GAP-43 axis in dorsal column lesion. — PubMed · 2025 · Journal Article
- Exosomal miR-494 from Bone Marrow Mesenchymal Stem Cells Attenuates Ferroptosis and Enhances Spinal Cord Injury Repair by Modulating the SIRT1/HO-1 Pathway. — PubMed · 2025 · Journal Article
- Pharmacological Activation of GPR68 Attenuates Ferroptosis in Spinal Cord Ischemia/Reperfusion Injury Through PI3K/Akt-Mediated Nrf2 Antioxidant Pathway. — PubMed · 2025 · Journal Article
- [Underlying Mechanism of the circ_0011462/miRNA-1200/SP1 Axis in Regulating Inflammatory Response, Apoptosis, and Neural Regeneration in a Spinal Cord Injury Model]. — PubMed · 2025 · English Abstract
- Machine Learning Identifies FLNA as a Key Molecular Target Regulating Neuronal Apoptosis after Spinal Cord Injury. — PubMed · 2025 · Journal Article
- ATF3 enhancement of CHAC1 expression: A pathway to neuronal ferroptosis in spinal cord injury. — PubMed · 2025 · Journal Article
- miR-218a-5p derived from neural stem cell-exosomes inhibits ferroptosis in spinal cord injury through the Bmil/Mettl3/Alox12 axis. — PubMed · 2025 · Journal Article
- MYCN-mediated pyroptosis and inflammation in the molecular mechanism of MicroRNA-202-3P promote functional recovery in spinal cord injury. — PubMed · 2025 · Journal Article
- Ptbp1 knockdown induces conversion of rat spinal cord astrocytes into neuron like cells. — PubMed · 2025 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])