A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- miR-378-3p alleviates contusion spinal cord injury by negatively regulating ATG12. — PubMed · 2021 · Journal Article
- Up-regulation of miR-338-5p after spinal cord injury enhances the neuronal repair via inhibition of inflammation aggravation and oxidative stress. — PubMed · 2021 · Letter
- miR-21a-5p Promotes Inflammation following Traumatic Spinal Cord Injury through Upregulation of Neurotoxic Reactive Astrocyte (A1) Polarization by Inhibiting the CNTF/STAT3/Nkrf Pathway. — PubMed · 2021 · Journal Article
- Long noncoding RNA ZFAS1 aggravates spinal cord injury by binding with miR-1953 and regulating the PTEN/PI3K/AKT pathway. — PubMed · 2021 · Journal Article
- LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels. — PubMed · 2021 · Journal Article
- SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats. — PubMed · 2021 · Journal Article
- Downregulating lncRNA PVT1 Relieves Astrocyte Overactivation Induced Neuropathic Pain Through Targeting miR-186-5p/CXCL13/CXCR5 Axis. — PubMed · 2021 · Journal Article
- EphB2 knockdown decreases the formation of astroglial-fibrotic scars to promote nerve regeneration after spinal cord injury in rats. — PubMed · 2021 · Journal Article
- LncRNA CASC9 attenuates lactate dehydrogenase-mediated oxidative stress and inflammation in spinal cord injury via sponging miR-383-5p. — PubMed · 2021 · Journal Article
- LncRNA H19 Regulates Lipopolysaccharide (LPS)-Induced Apoptosis and Inflammation of BV2 Microglia Cells Through Targeting miR-325-3p/NEUROD4 Axis. — PubMed · 2021 · Journal Article
- LncRNA Neat1 Promotes Regeneration after Spinal Cord Injury by Targeting miR-29b. — PubMed · 2021 · Journal Article
- miR-219 overexpressing oligodendrocyte progenitor cells for treating compression spinal cord injury. — PubMed · 2021 · Journal Article
- miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury. — PubMed · 2021 · Journal Article
- MicroRNA-145-Mediated KDM6A Downregulation Enhances Neural Repair after Spinal Cord Injury via the NOTCH2/Abcb1a Axis. — PubMed · 2021 · Journal Article
- EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5. — PubMed · 2021 · Journal Article
- CCR2 downregulation attenuates spinal cord injury by suppressing inflammatory monocytes. — PubMed · 2021 · Journal Article
- Lithium alleviated spinal cord injury (SCI)-induced apoptosis and inflammation in rats via BDNF-AS/miR-9-5p axis. — PubMed · 2021 · Journal Article
- Mesenchymal stem cell-derived exosomes containing miR-145-5p reduce inflammation in spinal cord injury by regulating the TLR4/NF-κB signaling pathway. — PubMed · 2021 · Journal Article
- NF-κB 1-induced LINC00665 regulates inflammation and apoptosis of neurons caused by spinal cord injury by targeting miR-34a-5p. — PubMed · 2021 · Journal Article
- Novel circular RNA 2960 contributes to secondary damage of spinal cord injury by sponging miRNA-124. — PubMed · 2021 · Journal Article
- MICAL1 (molecule interacting with CasL 1) protects oligodendrocyte cells from oxidative injury through regulating apoptosis, autophagy in spinal cord injury. — PubMed · 2021 · Journal Article
- miRNA-221 Regulates Spinal Cord Injury-Induced Inflammatory Response through Targeting TNF-α Expression. — PubMed · 2021 · Journal Article The source marks this record as retracted.
- Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury. — PubMed · 2021 · Journal Article
- Exosomes with high level of miR-181c from bone marrow-derived mesenchymal stem cells inhibit inflammation and apoptosis to alleviate spinal cord injury. — PubMed · 2021 · Journal Article
- Knockdown of SNHG1 alleviates autophagy and apoptosis by regulating miR-362-3p/Jak2/stat3 pathway in LPS-injured PC12 cells. — PubMed · 2021 · Journal Article
- MiR-152 inhibits neuronal axon growth after spinal cord injury through regulating p38 MAPK signaling pathway. — PubMed · 2021 · Journal Article
- Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury via microRNA-130b-5p/TLR4/NF-κB axis. — PubMed · 2021 · Journal Article
- Knockdown of miR-130a-3p alleviates spinal cord injury induced neuropathic pain by activating IGF-1/IGF-1R pathway. — PubMed · 2021 · Journal Article
- LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression. — PubMed · 2021 · Journal Article
- Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway in rats. — PubMed · 2021 · Journal Article
- TRPA1 involved in miR-141-5p-alleviated neuropathic pain induced by oxaliplatin. — PubMed · 2021 · Journal Article
- Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model. — PubMed · 2021 · Journal Article
- MicroRNA-139-5p Promotes Functional Recovery and Reduces Pain Hypersensitivity in Mice with Spinal Cord Injury by Targeting Mammalian Sterile 20-like Kinase 1. — PubMed · 2021 · Journal Article
- MicroRNA-211-5p attenuates spinal cord injury via targeting of activating transcription factor 6. — PubMed · 2021 · Journal Article
- Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential. — PubMed · 2021 · Journal Article
- The lncRNA Ftx/miR-382-5p/Nrg1 axis improves the inflammation response of microglia and spinal cord injury repair. — PubMed · 2021 · Journal Article
- NIMA-related kinase 7 amplifies NLRP3 inflammasome pro-inflammatory signaling in microglia/macrophages and mice models of spinal cord injury. — PubMed · 2021 · Journal Article
- Upregulating miR-130a-5p relieves astrocyte over activation-induced neuropathic pain through targeting C-X-C motif chemokine receptor 12/C-X-C motif chemokine receptor 4 axis. — PubMed · 2021 · Journal Article
- Knockdown of long non-coding RNA LEF1-AS1 attenuates apoptosis and inflammatory injury of microglia cells following spinal cord injury. — PubMed · 2021 · Journal Article
- Dynamics of biomarkers across the stages of traumatic spinal cord injury - implications for neural plasticity and repair. — PubMed · 2021 · Journal Article
- MicroRNA-22-3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5. — PubMed · 2021 · Journal Article
- MiR-19b-3p accelerates bone loss after spinal cord injury by suppressing osteogenesis via regulating PTEN/Akt/mTOR signalling. — PubMed · 2021 · Journal Article
- Combination of In Situ Lcn2 pRNA-RNAi Nanotherapeutics and iNSC Transplantation Ameliorates Experimental SCI in Mice. — PubMed · 2020 · Journal Article
- Matrine protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via upregulation of miR-9. — PubMed · 2020 · Journal Article
- MiR-124 improves spinal cord injury in rats by activating the Wnt/β-catenin signaling pathway. — PubMed · 2020 · Letter
- Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury. — PubMed · 2020 · Journal Article
- LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis. — PubMed · 2020 · Journal Article
- microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation. — PubMed · 2020 · Journal Article
- miR-27a promotion resulting from silencing of HDAC3 facilitates the recovery of spinal cord injury by inhibiting PAK6 expression in rats. — PubMed · 2020 · Journal Article
- miR-30b Promotes spinal cord sensory function recovery via the Sema3A/NRP-1/PlexinA1/RhoA/ROCK Pathway. — PubMed · 2020 · Journal Article
- Range of Neurological Signs in Cynomolgus Monkeys After Intrathecal Bolus Administration of Antisense Oligonucleotides. — PubMed · 2020 · Journal Article
- Serum exosomal microRNA transcriptome profiling in subacute spinal cord injured rats. — PubMed · 2020 · Journal Article
- mRNA and miRNA expression profile reveals the role of miR-31 overexpression in neural stem cell. — PubMed · 2020 · Journal Article
- Exosomes derived from miR-544-modified mesenchymal stem cells promote recovery after spinal cord injury. — PubMed · 2020 · Journal Article
- High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death. — PubMed · 2020 · Journal Article
- MicroRNA-34c promotes neuronal recovery in rats with spinal cord injury through the C-X-C motif ligand 14/Janus kinase 2/signal transducer and activator of transcription-3 axis. — PubMed · 2020 · Journal Article
- Promoting functions of microRNA-29a/199B in neurological recovery in rats with spinal cord injury through inhibition of the RGMA/STAT3 axis. — PubMed · 2020 · Journal Article
- MiR-139-5p alleviates neural cell apoptosis induced by spinal cord injury through targeting TRAF3. — PubMed · 2020 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])