A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Hypoxia inducible factor-1 (HIF-1α) reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723. — PubMed · 2020 · Journal Article
- Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture. — PubMed · 2020 · Journal Article
- Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes. — PubMed · 2020 · Journal Article
- TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT. — PubMed · 2020 · Journal Article
- Excess administration of miR-340-5p ameliorates spinal cord injury-induced neuroinflammation and apoptosis by modulating the P38-MAPK signaling pathway. — PubMed · 2020 · Journal Article
- Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice. — PubMed · 2020 · Journal Article
- MiR-615 Regulates NSC Differentiation In Vitro and Contributes to Spinal Cord Injury Repair by Targeting LINGO-1. — PubMed · 2020 · Journal Article
- mRNA Profiling for miR-124-mediated Repair in Spinal Cord Injury. — PubMed · 2020 · Journal Article
- Adipose mesenchymal stem cell transplantation alleviates spinal cord injury-induced neuroinflammation partly by suppressing the Jagged1/Notch pathway. — PubMed · 2020 · Journal Article
- Curcumin protects BV2 cells against lipopolysaccharide-induced injury via adjusting the miR-362-3p/TLR4 axis. — PubMed · 2020 · Journal Article
- The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain. — PubMed · 2020 · Journal Article
- MicroRNA-92a-3p enhances functional recovery and suppresses apoptosis after spinal cord injury via targeting phosphatase and tensin homolog. — PubMed · 2020 · Journal Article
- miR-384-5p promotes spinal cord injury recovery in rats through suppressing of autophagy and endoplasmic reticulum stress. — PubMed · 2020 · Journal Article
- MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury. — PubMed · 2020 · Journal Article
- Loss of SNHG4 Attenuated Spinal Nerve Ligation-Triggered Neuropathic Pain through Sponging miR-423-5p. — PubMed · 2020 · Journal Article
- LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3. — PubMed · 2020 · Journal Article
- Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization. — PubMed · 2020 · Journal Article
- MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathway. — PubMed · 2020 · Journal Article
- MiR-24 inhibits oligodendrocyte precursor cell differentiation after spinal injury by targeting adrenal medulla. — PubMed · 2020 · Journal Article
- Serum exosomal microRNA transcriptome profiling in subacute spinal cord injured rats. — PubMed · 2020 · Journal Article
- The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway. — PubMed · 2020 · Journal Article
- [Identification of potential traumatic spinal cord injury related circular RNA-microRNA networks by sequence analysis]. — PubMed · 2020 · Journal Article
- Integrated analysis of competing endogenous RNA (ceRNA) networks in subacute stage of spinal cord injury. — PubMed · 2020 · Journal Article
- Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization. — PubMed · 2020 · Journal Article
- MicroRNA-34a suppresses neuronal apoptosis and alleviates microglia inflammation by negatively targeting the Notch pathway in spinal cord injury. — PubMed · 2020 · Journal Article
- RETRACTED: Knockdown PEG10 deteriorates H(2)O(2)-injury of PC-12 cells by targeting miR-34a-5p/TLX. — PubMed · 2020 · Journal Article The source marks this record as retracted.
- microRNA-331-3p attenuates neuropathic pain following spinal cord injury via targeting RAP1A. — PubMed · 2020 · Journal Article
- MiR-7a ameliorates spinal cord injury by inhibiting neuronal apoptosis and oxidative stress. — PubMed · 2020 · Journal Article
- MiRNA-125a-5p attenuates blood-spinal cord barrier permeability under hypoxia in vitro. — PubMed · 2020 · Journal Article
- MiRNA-411 attenuates inflammatory damage and apoptosis following spinal cord injury. — PubMed · 2020 · Journal Article
- Suppression of miR-10a-5p in bone marrow mesenchymal stem cells enhances the therapeutic effect on spinal cord injury via BDNF. — PubMed · 2020 · Journal Article
- The transcription factor Foxd3 induces spinal cord ischemia-reperfusion injury by potentiating microRNA-214-dependent inhibition of Kcnk2. — PubMed · 2020 · Journal Article
- Transplantation of sh-miR-199a-5p-Modified Olfactory Ensheathing Cells Promotes the Functional Recovery in Rats with Contusive Spinal Cord Injury. — PubMed · 2020 · Journal Article
- Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury. — PubMed · 2019 · Journal Article
- Curcumin Alleviates Lipopolysaccharide (LPS)-Activated Neuroinflammation via Modulation of miR-199b-5p/IκB Kinase β (IKKβ)/Nuclear Factor Kappa B (NF-κB) Pathway in Microglia. — PubMed · 2019 · Journal Article
- LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells. — PubMed · 2019 · Journal Article
- Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism. — PubMed · 2019 · Journal Article
- Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats. — PubMed · 2019 · Journal Article
- CRNDE enhances neuropathic pain via modulating miR-136/IL6R axis in CCI rat models. — PubMed · 2019 · Journal Article
- Downregulation of miRNA-127-5p aggravates spinal cord injury through activating MAPK1. — PubMed · 2019 · Journal Article
- Geniposide protects PC12 cells from lipopolysaccharide-evoked inflammatory injury via up-regulation of miR-145-5p. — PubMed · 2019 · Journal Article
- Long non-coding RNA SNHG16 reduces hydrogen peroxide-induced cell injury in PC-12 cells by up-regulating microRNA-423-5p. — PubMed · 2019 · Journal Article The source marks this record as retracted.
- miR-21 deficiency contributes to the impaired protective effects of obese rat mesenchymal stem cell-derived exosomes against spinal cord injury. — PubMed · 2019 · Journal Article
- Notoginsenoside R1 alleviates lipopolysaccharide-triggered PC-12 inflammatory damage via elevating microRNA-132. — PubMed · 2019 · Journal Article
- Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway. — PubMed · 2019 · Journal Article The source marks this record as retracted.
- Protective functions of salvianolic acid B in PC-12 cells against hydrogen peroxide-triggered damage by mediation of microRNA-26a. — PubMed · 2019 · Journal Article
- Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice. — PubMed · 2019 · Journal Article
- Protective Effects of MiR-129-5p on Acute Spinal Cord Injury Rats. — PubMed · 2019 · Journal Article
- MicroRNA expression in the cerebrospinal fluid of dogs with and without cervical spondylomyelopathy. — PubMed · 2019 · Journal Article
- MiR-223-5p inhibitor suppresses microglia inflammation and promotes Nrg-1 in rats of spinal cord injury. — PubMed · 2019 · Journal Article
- MiR-379-5p improved locomotor function recovery after spinal cord injury in rats by reducing endothelin 1 and inhibiting astrocytes expression. — PubMed · 2019 · Journal Article
- Relationships between microRNA-20a and microRNA-125b expression and apoptosis and inflammation in experimental spinal cord injury. — PubMed · 2019 · Journal Article
- Suppression of LINC00707 alleviates lipopolysaccharide-induced inflammation and apoptosis in PC-12 cells by regulated miR-30a-5p/Neurod 1. — PubMed · 2019 · Journal Article
- Identification of serum exosomal microRNAs in acute spinal cord injured rats. — PubMed · 2019 · Journal Article
- Long non-coding RNA TUG1 alleviates LPS-induced injury of PC-12 cells by down-regulating microRNA-127. — PubMed · 2019 · Journal Article The source marks this record as retracted.
- MAP‑1B, PACS‑2 and AHCYL1 are regulated by miR‑34A/B/C and miR‑449 in neuroplasticity following traumatic spinal cord injury in rats: Preliminary explorative results from microarray data. — PubMed · 2019 · Journal Article
- MiR-100 suppresses inflammatory activation of microglia and neuronal apoptosis following spinal cord injury via TLR4/NF-κB pathway. — PubMed · 2019 · Journal Article
- Prospects of siRNA cocktails as tools for modifying multiple gene targets in the injured spinal cord. — PubMed · 2019 · Journal Article
- Silencing miR-21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription-3 pathway after acute ischemic spinal cord injury. — PubMed · 2019 · Journal Article
- Targeting miR-106-3p facilitates functional recovery via inactivating inflammatory microglia and interfering glial scar component deposition after neural injury. — PubMed · 2019 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])