Chondroitinase ABC

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What belongs here

The enzyme that cleaves the scar’s inhibitory molecules, injected or gene-delivered.

What does not belong here, however close it looks

Other ways of neutralising the same molecules are the proteoglycan-modulation concept.

What has been looked at

Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.

• Registered or indexed as work in people: 61 records · 2002–2025
• Indexed as work in animals: 126 records · 2002–2026
• Indexed as laboratory work: 10 records · 2009–2025
• The source has not said who or what was studied: 81 records · 2000–2026

• No clinical trial on this subject is registered for spinal cord injury.

Checked

Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.

• Chondroitinase ABC administration improves locomotor recovery after spinal cord injury.
• Enzymatic degradation of chondroitin sulfate proteoglycans with Chondroitinase ABC improves motor function after spinal cord injury.
• The locomotor benefit of chondroitinase ABC after spinal cord injury is not modified by follow-up duration or by the locomotor scoring scale used.
• The locomotor benefit of chondroitinase ABC after spinal cord injury is not modified by the injury model, the injury severity, or the number of administrations.
• A systematic review and meta-analysis of chondroitinase ABC promotes functional recovery in rat models of spinal cord injury.
• Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC
• Chondroitinase ABC
• Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis.
• Chondroitinase ABC combined with Schwann cell transplantation enhances axonal regrowth after spinal cord injury.
• Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury.
• Chondroitinase ABC combined with Schwann cell transplantation improves locomotor recovery after spinal cord injury.
• Chondroitinase ABC combined with Schwann cell transplantation improves urinary bladder function after spinal cord injury.

Found in the scientific sources, not yet checked

Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.

278 records

This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.

Where this was looked for, and when

The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.

Subjects next to this one

• Glial scar and its remodelling
• Scar proteoglycan modulation