A subject this map covers
Extracellular vesicles and exosomes
Part of: Cell therapy
What belongs here
Products of cells without the cells: vesicles, exosomes, conditioned medium, delivered in spinal cord injury.
What does not belong here, however close it looks
Delivering living cells, even when the authors credit their vesicles, is cell therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 226 records · 2000–2026
- Indexed as work in animals: 224 records · 1998–2026
- Indexed as laboratory work: 33 records · 2003–2026
- The source has not said who or what was studied: 171 records · 1977–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
654 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord. — PubMed · 2018 · Journal Article
- Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury. — PubMed · 2018 · Journal Article
- Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats. — PubMed · 2017 · Journal Article
- Co-transplantation of mesenchymal and neural stem cells and overexpressing stromal-derived factor-1 for treating spinal cord injury. — PubMed · 2017 · Journal Article
- Effect of transplantation of olfactory ensheathing cell conditioned medium induced bone marrow stromal cells on rats with spinal cord injury. — PubMed · 2017 · Journal Article
- Neural Stem Cell-Conditioned Medium Suppresses Inflammation and Promotes Spinal Cord Injury Recovery. — PubMed · 2017 · Journal Article
- Down-Regulation of miRNA-128 Contributes to Neuropathic Pain Following Spinal Cord Injury via Activation of P38. — PubMed · 2017 · Journal Article
- Bone marrow mesenchymal stem cells decrease CHOP expression and neuronal apoptosis after spinal cord injury. — PubMed · 2017 · Journal Article
- Transplantation of Pro-Oligodendroblasts, Preconditioned by LPS-Stimulated Microglia, Promotes Recovery After Acute Contusive Spinal Cord Injury. — PubMed · 2016 · Journal Article
- Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p. — PubMed · 2016 · Journal Article
- Bone marrow mesenchymal stem cells attenuate 2,5-hexanedione-induced neuronal apoptosis through a NGF/AKT-dependent pathway. — PubMed · 2016 · Journal Article
- Toll like receptor 9 antagonism modulates spinal cord neuronal function and survival: Direct versus astrocyte-mediated mechanisms. — PubMed · 2016 · Journal Article
- Calpain inhibitor attenuates ER stress-induced apoptosis in injured spinal cord after bone mesenchymal stem cells transplantation. — PubMed · 2016 · Journal Article
- Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration. — PubMed · 2015 · Journal Article
- Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury. — PubMed · 2015 · Journal Article
- Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury. — PubMed · 2015 · Journal Article
- Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury. — PubMed · 2014 · Journal Article
- Cotransplantation of glial restricted precursor cells and Schwann cells promotes functional recovery after spinal cord injury. — PubMed · 2013 · Journal Article
- Transplantation of D15A-expressing glial-restricted-precursor-derived astrocytes improves anatomical and locomotor recovery after spinal cord injury. — PubMed · 2013 · Journal Article
- Effects of andrographolide and 14-deoxy-11,12-didehydroandrographolide on cultured primary astrocytes and PC12 cells. — PubMed · 2012 · Journal Article
- ErbB2 activation contributes to de-differentiation of astrocytes into radial glial cells following induction of scratch-insulted astrocyte conditioned medium. — PubMed · 2011 · Journal Article
- Reactive astrocytes inhibit the survival and differentiation of oligodendrocyte precursor cells by secreted TNF-α. — PubMed · 2011 · Journal Article
- Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types. — PubMed · 2011 · Journal Article
- Reactive astrocytes in glial scar attract olfactory ensheathing cells migration by secreted TNF-alpha in spinal cord lesion of rat. — PubMed · 2009 · Journal Article
- Muscle-conditioned media and cAMP promote survival and neurite outgrowth of adult spinal cord motor neurons. — PubMed · 2009 · Journal Article
- Olfactory ensheathing cells promote proliferation and inhibit neuronal differentiation of neural progenitor cells through activation of Notch signaling. — PubMed · 2008 · Journal Article
- Olfactory ensheathing cells promote migration of Schwann cells by secreted nerve growth factor. — PubMed · 2007 · Journal Article
- Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons. — PubMed · 2007 · Journal Article
- Fibroblast growth factor treatment produces differential effects on survival and neurite outgrowth from identified bulbospinal neurons in vitro. — PubMed · 2000 · Journal Article
- Transmural compression-induced proliferation and DNA synthesis through activation of a tyrosine kinase pathway in rat astrocytoma RCR-1 cells. — PubMed · 1998 · Journal Article
Indexed as laboratory work
- Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury. — PubMed · 2026 · Journal Article
- Dental pulp stem cell-derived exosomes promote axonal repair in spinal cord injury by suppressing neuroinflammation and apoptosis. — PubMed · 2026 · Journal Article
- Peripheral Blood-Derived Mesenchymal Stem Cells Promote A2 Phenotype Polarization in Astrocytes via TGF-β-Mediated PI3K/Akt Pathway Activation. — PubMed · 2025 · Journal Article
- Engineered Extracellular Vesicles from Antler Blastema Progenitor Cells: A Therapeutic Choice for Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Spinal Cord Repair: From Cells and Tissue Engineering to Extracellular Vesicles. — PubMed · 2021 · Journal Article
- The Effect of Inflammatory Priming on the Therapeutic Potential of Mesenchymal Stromal Cells for Spinal Cord Repair. — PubMed · 2021 · Journal Article
- An In Vitro Comparison of the Neurotrophic and Angiogenic Activity of Human and Canine Adipose-Derived Mesenchymal Stem Cells (MSCs): Translating MSC-Based Therapies for Spinal Cord Injury. — PubMed · 2020 · Comparative Study
- The superiority of conditioned medium derived from rapidly expanded mesenchymal stem cells for neural repair. — PubMed · 2019 · Journal Article
- TGF-β Secretion by M2 Macrophages Induces Glial Scar Formation by Activating Astrocytes In Vitro. — PubMed · 2019 · Journal Article
- Effect of Differently Polarized Macrophages on Proliferation and Differentiation of Ependymal Cells from Adult Spinal Cord. — PubMed · 2019 · Journal Article
- Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment. — PubMed · 2018 · Journal Article
- The neuroprotective effect of rat adipose tissue-derived mesenchymal stem cell-conditioned medium on cortical neurons using an in vitro model of SCI inflammation. — PubMed · 2018 · Journal Article
- Conditioned medium of olfactory ensheathing cells promotes the functional recovery and axonal regeneration after contusive spinal cord injury. — PubMed · 2017 · Journal Article
- Non-viral xylosyltransferase-1 siRNA delivery as an effective alternative to chondroitinase in an in vitro model of reactive astrocytes. — PubMed · 2016 · Journal Article
- Glial restricted precursors maintain their permissive properties after long-term expansion but not following exposure to pro-inflammatory factors. — PubMed · 2015 · Journal Article
- CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. — PubMed · 2015 · Journal Article
- Astrocyte-conditioned medium attenuates glutamate-induced apoptotic cell death in primary cultured spinal cord neurons of rats. — PubMed · 2015 · Journal Article
- Isolation and long-term expansion of functional, myelinating oligodendrocyte progenitor cells from neonatal rat brain. — PubMed · 2014 · Journal Article
- Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. — PubMed · 2014 · Journal Article
- Primary olfactory mucosal cells promote axonal outgrowth in a three-dimensional assay. — PubMed · 2014 · Journal Article
- Conditioned medium of Wnt/β-catenin signaling-activated olfactory ensheathing cells promotes synaptogenesis and neurite growth in vitro. — PubMed · 2013 · Journal Article
- Conditioned medium from bone marrow-derived mesenchymal stem cells improves recovery after spinal cord injury in rats: an original strategy to avoid cell transplantation. — PubMed · 2013 · Journal Article
- Combining adult stem cells and olfactory ensheathing cells: the secretome effect. — PubMed · 2013 · Journal Article
- The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition. — PubMed · 2012 · Comparative Study
- Response of cartilage and meniscus tissue explants to in vitro compressive overload. — PubMed · 2012 · Journal Article
- Curcumin attenuates the expression and secretion of RANTES after spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro. — PubMed · 2011 · Journal Article
- Characterization of conditioned medium of cultured bone marrow stromal cells. — PubMed · 2010 · Journal Article
- The effect of umbilical cord blood cells on outcomes after experimental traumatic spinal cord injury. — PubMed · 2010 · Journal Article
- Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. — PubMed · 2010 · Journal Article
- The differentiation of rat adipose-derived stem cells into OEC-like cells on collagen scaffolds by co-culturing with OECs. — PubMed · 2007 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 3 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 963561 · this programme has 49 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 12 · this programme has 639 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("extracellular vesicle" OR "exosome" OR "conditioned medium" OR "secretome") - Crossref
spinal cord injury extracellular vesicle exosome - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Extracellular Vesicles"[MeSH Terms] OR "Exosomes"[MeSH Terms] OR "extracellular vesicle"[Title/Abstract] OR "exosome"[Title/Abstract] OR "conditioned medium"[Title/Abstract] OR "secretome"[Title/Abstract])