A subject this map covers
Immunomodulatory drugs
Part of: Inflammation and immune response
What belongs here
Drugs that change the immune response after injury, other than steroids and minocycline, which have their own concepts.
What does not belong here, however close it looks
Immunosuppression to keep a graft alive is part of cell therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 678 records · 1968–2026
- Indexed as work in animals: 932 records · 1982–2026
- Indexed as laboratory work: 34 records · 1991–2026
- The source has not said who or what was studied: 437 records · 1977–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
2081 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- SPP1 expression after spinal cord compression injury and its effects on glial cell activation. — PubMed · 2025 · Journal Article
- 1,8-Cineole alleviates spinal cord injury by inhibiting microglial pyroptosis via the P38 MAPK and PI3K/AKT/NLRP3 signaling pathways to protects neurons. — PubMed · 2025 · Journal Article
- Dental pulp stem cells promote the recovery of spinal cord injury by regulating microglia polarization via JAK2/STAT3 signaling pathway. — PubMed · 2025 · Journal Article
- Abscisic Acid Regulates Immune-inflammatory Responses to Induce Neuroprotection in Spinal Cord Injury: Insights from Gene Expression and Network Analysis. — PubMed · 2025 · Journal Article
- Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway. — PubMed · 2025 · Journal Article
- GDF11 alleviates spinal cord injury in rats by modulating microglia polarization through Smad2/3 and MAPK/NFκB signaling pathways. — PubMed · 2025 · Journal Article
- Phenserine Mitigates Neuroinflammation, Apoptosis, and Behavioural Deficits to Enhance Motor Function and Recovery in a Mouse Model of Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Roflumilast inhibits neuronal ferroptosis via AMPK/Nrf2/HO-1 signaling and promotes motor function recovery after spinal cord injury in rats. — PubMed · 2025 · Journal Article
- Adaptive Phenol-Based Hydrogel Embedded with Metformin Nanoparticles Targets Oxidative Stress and Ferroptosis for Spinal Cord Injury Repair. — PubMed · 2025 · Journal Article
- Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats). — PubMed · 2025 · Journal Article
- Forced polarisation of microglia by IL-13 is modified by inflammatory and microenvironmental context. — PubMed · 2025 · Journal Article
- Bilirubin Alleviates Spinal Cord Injury by Enhancing SOCS3-Mediated Anti-Inflammatory Effects via Gas6-Axl Signaling. — PubMed · 2025 · Journal Article
- Ganoderma lucidum low molecular weight polysaccharide promotes the repair of spinal cord injury through anti-inflammatory and antioxidant. — PubMed · 2025 · Journal Article
- Intermittent Electrical Stimulation-Induced Contractions Accelerate Pro-Regenerative Processes in Muscles With Deep Tissue Injury in Rats. — PubMed · 2025 · Journal Article
- Nasal Delivery of Engineered Exosomes via a Thermo-Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair. — PubMed · 2025 · Journal Article
- Preventive and therapeutic effects of Tanshinone IIA on spinal cord injury without radiographic abnormality by regulating microglial phenotype polarization. — PubMed · 2025 · Journal Article
- Tibolone Improves Motor Recovery and Regulates Neuroinflammation and Gliosis in a Model of Traumatic Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Sparc Suppresses Microglial Neuroinflammation and Promotes Axonal Regeneration by Interacting With Uba52. — PubMed · 2025 · Journal Article
- Liposomal ellagic acid enhances the regenerative potential of ADMSC-laden nanofibrous PCL scaffolds in a rat model of spinal cord injury. — PubMed · 2025 · Journal Article
- Spinal Cord Injury Treatment by Applying a Composite Scaffold Transplanted with Mesenchymal Stem Cells and Chitosan-Coated Nanostructured Lipid Carriers of Curcumin. — PubMed · 2025 · Journal Article
- Mechanistic Study of Jaceosidin in Regulating Secondary Inflammation After Spinal Cord Injury in Mouse by Inhibiting PKM2 Activity. — PubMed · 2025 · Journal Article
- Magnetically Driven Biomimetic Microrobot Loaded with Eleutheroside B for Targeted Delivery and Neural Repair in Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Impact of Corn Silk Extract on paclitaxel-induced spinal cord and sciatic nerve injuries in rats: Biochemical and histological evaluation. — PubMed · 2025 · Journal Article
- Transplantation of miR-216a-5p-overexpressing mesenchymal stem cells encapsulated in a thermosensitive hydrogel promotes functional recovery in a rat model of spinal cord injury. — PubMed · 2025 · Journal Article
- Repair of spinal cord injury using a time-specific four-dimensional multifunctional hydrogel with anti-inflammatory and neuronal differentiated microenvironments. — PubMed · 2025 · Journal Article
- Phosphodiesterase 2A as a Therapeutic Target for Relieving Mechanical Allodynia and Modulating Microglial Polarization in Neuropathic Pain Models Following Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Bone marrow mesenchymal stem cells-derived exosomal miR-24-3p alleviates spinal cord injury by targeting MAPK9 to inhibit the JNK/c-Jun/c-Fos pathway. — PubMed · 2025 · Journal Article
- Case-Control Investigation of Association of Clinician-Determined Variables With Progressive Myelomalacia After Acute Thoracolumbar Disc Extrusion in Dogs. — PubMed · 2025 · Journal Article
- Hyaluronan-bisphosphonate conjugate: A macromolecular anti-inflammatory agent and gas delivery system for neuroimmunomodulation in spinal cord injury. — PubMed · 2025 · Journal Article
- Hyaluronic acid methacryloyl hydrogel with sustained IL-10 release promotes macrophage M2 polarization and motor function after spinal cord injury. — PubMed · 2025 · Journal Article
- Identifying Microglia and Peripheral Infiltrating Macrophages in the Injured Spinal Cords Using Flow Cytometry. — PubMed · 2025 · Journal Article
- Xanthoxylin Regulating the Inflammatory Microenvironment After Spinal Cord Injury Through Inhibition of the NF-κB Signaling Pathway. — PubMed · 2025 · Journal Article
- Betulinic acid enhances autopahgy to promote microglial M2 polarization and alleviate inflammation via AMPK-HDAC5-KLF2 signaling pathways in spinal cord injury. — PubMed · 2025 · Journal Article
- Injectable thermosensitive hydrogel system based on hyaluronic acid and methylcellulose for the synergistic therapy of traumatic spinal cord injury. — PubMed · 2025 · Journal Article
- Polygonati Rhizoma polysaccharide suppresses microglial activation and promotes functional recovery of spinal cord via improving intestinal microbiota. — PubMed · 2025 · Journal Article
- Role of MS4A7 in Regulating Microglial Polarization and Neuroinflammation in Spinal Cord Injury via the cGAS-STING-NLRP3 Axis. — PubMed · 2025 · Journal Article
- TRIM55 suppresses inflammatory response after spinal cord injury by accelerating the ubiquitination and degradation of TLR4. — PubMed · 2025 · Journal Article
- Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinflammation and improves locomotor outcome following spinal cord injury. — PubMed · 2025 · Journal Article
- Hydrogen Sulfide Modulates Microglial Polarization and Remodels the Injury Microenvironment to Promote Functional Recovery After Spinal Cord Injury. — PubMed · 2025 · Journal Article
- lncRNA SNHG6 Knockdown Promotes Microglial M2 Polarization and Alleviates Spinal Cord Injury via Regulating the miR-182-5p/NEUROD4 Axis. — PubMed · 2025 · Journal Article
- Lupeol mitigates spinal cord injury by modulating microglial M1/M2 polarization via Na(+)/K(+)-ATPase-mediated mitophagy. — PubMed · 2025 · Journal Article
- Regulation of Nrf2/GPX4 Signaling Pathway by Hyperbaric Oxygen Protects Against Depressive Behavior and Cognitive Impairment in a Spinal Cord Injury Rat Model. — PubMed · 2025 · Journal Article
- MMP-responsive nanodrug loaded with glibenclamide for targeted repair of acute spinal cord injury. — PubMed · 2025 · Journal Article
- Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA/NF-κB signaling pathway. — PubMed · 2025 · Journal Article
- Targeted Delivery of Acid-Responsive Rutin Nanoparticles Based on Aldehyde Adsorption for the Treatment of Spinal Cord Injury in Rats. — PubMed · 2025 · Journal Article
- An engineering-reinforced extracellular vesicle-integrated hydrogel with an ROS-responsive release pattern mitigates spinal cord injury. — PubMed · 2025 · Journal Article
- Aloperine treatment attenuates acute spinal cord injury by reducing oxidative, inflammatory, and apoptotic responses via PI3K/AKT/NF-κB signaling in a rat contusion model. — PubMed · 2025 · Journal Article
- Astrocyte-conditional knockout of MOB2 inhibits the phenotypic conversion of reactive astrocytes from A1 to A2 following spinal cord injury in mice. — PubMed · 2025 · Journal Article
- Baicalin ameliorates neuroinflammation by targeting TLR4/MD2 complex on microglia via PI3K/AKT/NF-κB signaling pathway. — PubMed · 2025 · Journal Article
- Early Pro- and Anti-Inflammatory Immune Response Induced by Probiotic Treatment After Th9 Compression: The Interplay Between Spinal Cord and Jejunum. — PubMed · 2025 · Journal Article
- Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Sodium butyrate alleviates spinal cord injury via inhibition of NLRP3/Caspase-1/GSDMD-mediated pyroptosis. — PubMed · 2025 · Journal Article
- Sodium tanshinone IIA sulfonate promotes proliferation and differentiation of endogenous neural stem cells to repair rat spinal cord injury via the Notch pathway. — PubMed · 2025 · Journal Article
- Fidgetin-like 2 knockdown increases acute neuroinflammation and improves recovery in a rat model of spinal cord injury. — PubMed · 2025 · Journal Article
- Conditional deletion of IκBζ in hematopoietic cells promotes functional recovery after spinal cord injury in mice. — PubMed · 2025 · Journal Article
- Genetically Programmed Single-Component Protein Hydrogel for Spinal Cord Injury Repair. — PubMed · 2025 · Journal Article
- Neutrophil membrane-coated multifunctional biomimetic nanoparticles for spinal cord injuries. — PubMed · 2025 · Journal Article
- Resveratrol loaded microglia-derived exosomes attenuate astrogliasis by restoring mitochondrial function to reduce spinal cord injury. — PubMed · 2025 · Journal Article
- Fecal microbiota transplantation promotes functional recovery in mice with spinal cord injury by modulating the spinal cord microenvironment. — PubMed · 2025 · Journal Article
- Punicalagin inhibits neuron ferroptosis and secondary neuroinflammation to promote spinal cord injury recovery. — PubMed · 2025 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 13 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1741999 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 17 · this programme has 2063 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("immunomodulation" OR "anti-inflammatory") - Crossref
spinal cord injury immunomodulation anti-inflammatory - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Immunomodulating Agents"[MeSH Terms] OR "Anti-Inflammatory Agents"[MeSH Terms] OR "immunomodulation"[Title/Abstract] OR "anti-inflammatory"[Title/Abstract])