A subject this map covers
Immunomodulatory drugs
Part of: Inflammation and immune response
What belongs here
Drugs that change the immune response after injury, other than steroids and minocycline, which have their own concepts.
What does not belong here, however close it looks
Immunosuppression to keep a graft alive is part of cell therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 678 records · 1968–2026
- Indexed as work in animals: 932 records · 1982–2026
- Indexed as laboratory work: 34 records · 1991–2026
- The source has not said who or what was studied: 437 records · 1977–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
2081 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Urolithin A alleviates NLRP3 inflammasome activation and pyroptosis by promoting microglial mitophagy following spinal cord injury. — PubMed · 2025 · Journal Article
- Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury. — PubMed · 2025 · Journal Article
- Engineered Extracellular Vesicles Modified by Angiopep-2 Peptide Promote Targeted Repair of Spinal Cord Injury and Brain Inflammation. — PubMed · 2025 · Journal Article
- Clickable immune-microenvironment modulated hydrogels for spinal cord injury repair. — PubMed · 2025 · Journal Article
- DOCK2 deficiency alleviates neuroinflammation and affords neuroprotection after spinal cord injury. — PubMed · 2025 · Journal Article
- Effects of wavelength and spinal cord injury segment on photobiomodulation efficacy: Monte Carlo simulation in a rat model. — PubMed · 2025 · Journal Article
- Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-induced immunosuppression. — PubMed · 2025 · Journal Article
- A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation. — PubMed · 2025 · Journal Article
- SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia. — PubMed · 2025 · Journal Article
- A cryo-shocked M2 macrophages based treatment strategy promoting repair of spinal cord injury via immunomodulation and axonal regeneration effects. — PubMed · 2025 · Journal Article
- Depression-like behavior is associated with deficits in cognition and hippocampal neurogenesis in a subset of spinally contused male, but not female, rats. — PubMed · 2025 · Journal Article
- Electroacupuncture stimulation inhibited astrogliosis and microglia polarisation to alleviate spinal cord injury via Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. — PubMed · 2025 · Journal Article
- Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology. — PubMed · 2025 · Journal Article
- No impact of anti-inflammatory medication on inflammation-driven recovery following cervical spinal cord injury in rats. — PubMed · 2025 · Journal Article
- Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Amplification of Metalloregulatory Proteins in Macrophages by Bioactive ZnMn@SF Hydrogels for Spinal Cord Injury Repair. — PubMed · 2024 · Journal Article
- Low-energy extracorporeal shockwave therapy improves locomotor functions, tissue regeneration, and modulating the inflammation induced FGF1 and FGF2 signaling to protect damaged tissue in spinal cord injury of rat model: an experimental animal study. — PubMed · 2024 · Journal Article
- Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation. — PubMed · 2024 · Journal Article
- Neuroprotective agents ineffective in mitigating autonomic dysreflexia following experimental spinal cord injury. — PubMed · 2024 · Journal Article
- Induction of Neural Differentiation and Protection by a Novel Slow-Release Nanoparticle Estrogen Construct in a Rat Model of Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Resveratrol Enhances the Efficacy of Combined BM-MSCs Therapy for Rat Spinal Cord Injury via Modulation of the Sirt-1/NF-κB Signaling Pathway. — PubMed · 2024 · Journal Article
- P2Y12-targeted modulation of microglial phenotypes: A novel therapeutic strategy for enhanced axonal regeneration post-spinal cord injury. — PubMed · 2024 · Journal Article
- Effectiveness of Pharmacotherapy in Reducing the Inflammation Process of Spinal Cord Injuries: A Systematic Review of Animal Studies. — PubMed · 2024 · Journal Article
- Constructing Electron-Rich Ru Clusters on Non-Stoichiometric Copper Hydroxide for Superior Biocatalytic ROS Scavenging to Treat Inflammatory Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury. — PubMed · 2024 · Journal Article
- Natural Polyphenol Delivered Methylprednisolone Achieve Targeted Enrichment for Acute Spinal Cord Injury Therapy. — PubMed · 2024 · Journal Article
- Beyond expectations: safinamide's unprecedented neuroprotective impact on acute spinal cord injury. — PubMed · 2024 · Journal Article
- Delivery of TGFβ3 from Magnetically Responsive Coaxial Fibers Reduces Spinal Cord Astrocyte Reactivity In Vitro. — PubMed · 2024 · Journal Article
- Sovateltide (ILR-1620) Improves Motor Function and Reduces Hyperalgesia in a Rat Model of Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Low-Dose LPS Modulates Microglia/Macrophages Phenotypic Transformation to Amplify Rehabilitation Effects in Chronic Spinal Cord Injured (CSCI) Mice. — PubMed · 2024 · Journal Article
- Protective effect of valproic acid on ischemia-reperfusion induced spinal cord injury in a rat model. — PubMed · 2024 · Journal Article
- Protocatechuic aldehyde promotes the functional recovery of spinal cord injury by activating the Wnt/β-catenin signaling pathway. — PubMed · 2024 · Journal Article
- Tangeretin alleviates inflammation and oxidative response induced by spinal cord injury by activating the Sesn2/Keap1/Nrf2 pathway. — PubMed · 2024 · Journal Article
- Delayed administration of interleukin-4 coacervate alleviates the neurotoxic phenotype of astrocytes and promotes functional recovery after a contusion spinal cord injury. — PubMed · 2024 · Journal Article
- Metformin enhances endogenous neural stem cells proliferation, neuronal differentiation, and inhibits ferroptosis through activating AMPK pathway after spinal cord injury. — PubMed · 2024 · Journal Article
- Transplantation of miR-145a-5p modified M2 type microglia promotes the tissue repair of spinal cord injury in mice. — PubMed · 2024 · Journal Article
- A comprehensive and systematic review of the potential neuroprotective effect of quercetin in rat models of spinal cord injury. — PubMed · 2024 · Journal Article
- Carboxymethyl cellulose/quaternized chitosan hydrogel loaded with polydopamine nanoparticles promotes spinal cord injury recovery by anti-ferroptosis and M1/M2 polarization modulation. — PubMed · 2024 · Journal Article
- Fucoidan improving spinal cord injury recovery: Modulating microenvironment and promoting remyelination. — PubMed · 2024 · Journal Article
- miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1. — PubMed · 2024 · Journal Article
- Neuroimmune modulating and energy supporting nanozyme-mimic scaffold synergistically promotes axon regeneration after spinal cord injury. — PubMed · 2024 · Journal Article
- Comparative model of minimal spinal cord injury reveals a rather anti-inflammatory response in the lesion site as well as increased proliferation in the central canal lining in the neonates compared to the adult rats. — PubMed · 2024 · Journal Article
- Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice. — PubMed · 2024 · Journal Article
- Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair. — PubMed · 2024 · Journal Article
- Wogonoside alleviates microglia-mediated neuroinflammation via TLR4/MyD88/NF-κB signaling axis after spinal cord injury. — PubMed · 2024 · Journal Article
- Treatment of Syringomyelia Characterized by Focal Dilatation of the Central Canal Using Mesenchymal Stem Cells and Neural Stem Cells. — PubMed · 2024 · Journal Article
- Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response. — PubMed · 2024 · Journal Article
- 3D hydrogel microfibers promote the differentiation of encapsulated neural stem cells and facilitate neuron protection and axon regrowth after complete transactional spinal cord injury. — PubMed · 2024 · Journal Article
- In Situ Piezoelectric-Catalytic Anti-Inflammation Promotes the Rehabilitation of Acute Spinal Cord Injury in Synergy. — PubMed · 2024 · Journal Article
- Multifunctional Conductive and Electrogenic Hydrogel Repaired Spinal Cord Injury via Immunoregulation and Enhancement of Neuronal Differentiation. — PubMed · 2024 · Journal Article
- Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Sex Dependent Disparities in the Central Innate Immune Response after Moderate Spinal Cord Contusion in Rat. — PubMed · 2024 · Journal Article
- ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion. — PubMed · 2024 · Journal Article
- Spatiotemporal Dynamics of Neuroinflammation Relate to Behavioral Recovery in Rats with Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Fisetin orchestrates neuroinflammation resolution and facilitates spinal cord injury recovery through enhanced autophagy in pro-inflammatory glial cells. — PubMed · 2024 · Journal Article
- Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway. — PubMed · 2024 · Journal Article
- Comparison between stem cell therapy and stem cell derived exosomes on induced multiple sclerosis in dogs. — PubMed · 2024 · Journal Article
- Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury. — PubMed · 2024 · Journal Article
- Acetyl-11-keto-beta-boswellic acid modulates macrophage polarization and Schwann cell migration to accelerate spinal cord injury repair in rats. — PubMed · 2024 · Journal Article
- Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21/JAK2/STAT3 pathway. — PubMed · 2024 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 13 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1741999 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 17 · this programme has 2063 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("immunomodulation" OR "anti-inflammatory") - Crossref
spinal cord injury immunomodulation anti-inflammatory - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Immunomodulating Agents"[MeSH Terms] OR "Anti-Inflammatory Agents"[MeSH Terms] OR "immunomodulation"[Title/Abstract] OR "anti-inflammatory"[Title/Abstract])