A subject this map covers
Macrophage therapy and polarisation
Part of: Inflammation and immune response
What belongs here
Delivering or reprogramming macrophages to change the character of inflammation at the injury.
What does not belong here, however close it looks
Describing what macrophages do without intervening is mechanism, not therapy; such a record stays in the parent concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 265 records · 1967–2026
- Indexed as work in animals: 781 records · 1966–2026
- Indexed as laboratory work: 41 records · 1988–2026
- The source has not said who or what was studied: 211 records · 1999–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1298 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as laboratory work
- Activated autologous macrophage implantation in a large-animal model of spinal cord injury. — PubMed · 2008 · Journal Article
- Characterization and modeling of monocyte-derived macrophages after spinal cord injury. — PubMed · 2007 · Journal Article
- An overview of tissue engineering approaches for management of spinal cord injuries. — PubMed · 2007 · Journal Article
- Characterization of the early neuroinflammation after spinal cord injury in mice. — PubMed · 2007 · Comparative Study
- Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats. — PubMed · 2007 · Journal Article
- Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: phase I study results. — PubMed · 2005 · Clinical Trial
- In vitro spinal cord trauma. — PubMed · 1988 · Journal Article
The source has not said who or what was studied
- M1 macrophage-derived CXCL12 drives neurogenic heterotopic ossification following spinal cord injury. — PubMed · 2026 · Journal Article
- Context-dependent CCL2-CCR2 signaling drives distinct immune infiltration programs in traumatic and autoimmune CNS disorders. — PubMed · 2026 · Journal Article
- Lipid Signaling and Foam Cell Formation in Atherosclerosis and Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Neutrophil-Hitchhiking and Microenvironment-Responsive Cascade Nanoparticles for STING Inhibition and Spinal Cord Injury Repair. — PubMed · 2026 · Journal Article
- Exosomes target liver TREM-1 to break the systemic inflammatory cascade and improve spinal cord injury outcomes. — PubMed · 2026 · Journal Article
- Apolipoprotein E in spinal cord injury: mechanisms of lipid dysregulation, neuroinflammation, and opportunities for repair. — PubMed · 2026 · Journal Article
- Transplantation of LPS, IL-4, and TGF-β-induced reparative-biased macrophages promotes early motor functional recovery after spinal cord injury in rats. — PubMed · 2026 · Journal Article
- M2 polarization of macrophages: Manipulation of spinal cord injury repair. — PubMed · 2026 · Journal Article
- Retraction: The effects of the M2a macrophage-induced axonal regeneration of neurons by arginase 1. — PubMed · 2026 · Journal Article
- Hierarchical targeting biomimetic nanoparticles directing to lesion site and mitochondria promote neuroregeneration and attenuate inflammation after spinal cord injury. — PubMed · 2026 · Journal Article
- A low-crosslinking hydrogel integrating prodrug nanoparticles modulates neuroinflammation and ECM deposition for enhanced spinal cord regeneration. — PubMed · 2026 · Journal Article
- Sonic Hedgehog Signaling Promotes Survival and Lineage Specific Differentiation of Transplanted Neural Precursor Cells and Improves Motor Recovery After Thoracic Spinal Cord Injury in Rats. — PubMed · 2026 · Journal Article
- Exacerbation of neuronal senescence after spinal cord injury: Role of the macrophage-derived transforming growth factor-β1-SMAD2 signaling axis. — PubMed · 2026 · Journal Article
- Interferon regulatory factor 4-releasing 3D-printed scaffolds enhance spinal cord repair by modulating macrophage polarization. — PubMed · 2026 · Journal Article
- Corrigendum to " Panax notoginseng saponins ameliorate spinal cord injury by inhibiting JAK2/STAT3-mediated macrophage polarization: Enhanced delivery by ultrasound-targeted microbubble destruction" [Phytomedicine Volume 152, March 2026, 157856]. — PubMed · 2026 · Published Erratum
- D-dopachrome tautomerase promotes astrocytic cholesterol 25-hydroxylase expression through the ERK/NF-κB pathway following rat spinal cord injury. — PubMed · 2026 · Journal Article
- Interfering with PTBP1 expression promotes anti-inflammatory macrophage polarization alongside altered activity of the miR-124/p38MAPK pathway. — PubMed · 2026 · Journal Article
- GP130 Regulates Macrophage Polarization and Functional Recovery after Spinal Cord Injury in Rats: A Single-Cell RNA Sequencing Study — Crossref · 2026 · journal-article
- Immuno-engineered conductive hydrogels: Bridging neural signaling and microenvironmental remodeling for neural repair. — PubMed · 2026 · Journal Article
- Tea egg-inspired high mechanical strength hydrogel microneedle patch combined with tea polyphenol-magnesium nanoparticles promotes spinal cord injury repair. — PubMed · 2026 · Journal Article
- Emerging role of copper in the pathophysiology of spinal cord injury. — PubMed · 2026 · Journal Article
- Single-cell RNA sequencing of the post-spinal cord injury dorsal root ganglia in cynomolgus monkeys: Elucidation of the cellular immune microenvironment of the central nervous system. — PubMed · 2026 · Journal Article
- Fostering Regeneration and Functional Improvement in the Injured Spinal Cord by a Novel, Stem Cell Secretome-Based Drug Delivery Method. — PubMed · 2026 · Journal Article
- Correction: Differential microglial dynamics and neuroinflammation underlying neuropathic pain in the central nervous system: comparative insights from spinal cord injury and compressive myelopathy models. — PubMed · 2026 · Published Erratum
- Neonatal small extracellular vesicle-loaded GelNB hydrogel reprograms the vascular-immune microenvironment for spinal cord injury repair. — PubMed · 2026 · Journal Article
- Screening macrophage polarization genes in spinal cord injury as therapeutic targets — Crossref · 2026 · journal-article
- The SHEDs-derived apoptotic bodies for inflammatory regulation in spinal cord repair. — PubMed · 2026 · Journal Article
- Targeted biohybrid nanoplatform for spinal cord injury treatment: Restoring microglial mitophagy and alleviating oxidative stress. — PubMed · 2026 · Journal Article
- The Emerging Role of N-Lactoyl-Phenylalanine (Lac-Phe) in Metabolic Regulation and Disease: From Exercise-Induced Metabolite to Therapeutic Candidate. — PubMed · 2026 · Journal Article
- Exosome-derived ncRNAs and proteins: inflammation regulatory mechanisms and biomarker potential in spinal cord injury. — PubMed · 2026 · Journal Article
- Algorithmically defined therapeutic targets: integrating single-cell transfer learning frameworks with small molecule drugs to reverse disease-associated cell fates. — PubMed · 2026 · Journal Article
- Exosome Cargo Molecules and NLRP3/BDNF: Clinical and Preclinical Evidence for Acupuncture-Mediated Spinal Cord Injury Recovery. — PubMed · 2026 · Journal Article
- A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization. — PubMed · 2026 · Journal Article
- Systemic delivery of drug-free polymeric nanoparticles reprograms innate immunity in a sex-dependent manner after spinal cord injury. — PubMed · 2026 · Journal Article
- Mitochondrial metabolism restoration via Tramiprosate suppresses mitochondrial ROS-driven foamy macrophage senescence post spinal cord injury. — PubMed · 2026 · Journal Article
- P0595 miR-21-5p regulates macrophage M2 polarization and mediates bladder fibrosis after spinal cord injury — Crossref · 2026 · journal-article
- Panax notoginseng saponins ameliorate spinal cord injury by inhibiting JAK2/STAT3-mediated macrophage polarization: Enhanced delivery by ultrasound-targeted microbubble destruction — Crossref · 2026 · journal-article
- Profibrotic macrophage-derived CXCL4 promotes pericyte-to-myofibroblast transition after spinal cord injury. — PubMed · 2026 · Journal Article
- Can Transcutaneous Vagus Nerve Stimulation be Effective After Rats' Spinal Cord Injury? — PubMed · 2026 · Journal Article
- A single-cell landscape of the regenerating spinal cord of zebrafish. — PubMed · 2026 · Journal Article
- Temporal regulation of macrophage polarization by abnormally innervated CGRP + Sensory nerves following spinal cord injury — Crossref · 2026 · journal-article
- Differential microglial dynamics and neuroinflammation underlying neuropathic pain in the central nervous system: comparative insights from spinal cord injury and compressive myelopathy models. — PubMed · 2026 · Journal Article
- Omaveloxolone promotes functional recovery of spinal cord injury by reducing inflammatory response and regulating macrophage polarization. — PubMed · 2026 · Journal Article
- Intelligent structure prediction and visualization analysis Aof macrophage-mediated immunomodulation in spinal cord injury repair research — Crossref · 2026 · journal-article
- Spatiotemporal delivery of multifunctional nanozymes for neuroinflammation alleviation via autophagy modulation in spinal cord injury. — PubMed · 2025 · Journal Article
- Leveraging microbiota-metabolites to reduce inflammation and promote functional recovery following spinal cord injury in female mice. — PubMed · 2025 · Journal Article
- A dual-drug sequential delivery hydrogel for programmatic microglia/macrophage polarization and function recovery in spinal cord injury — Crossref · 2025 · journal-article
- Effect of Lycium barbarum polysaccharide on functional recovery after decompression in a rat model of degenerative cervical myelopathy. — PubMed · 2025 · Journal Article
- Engineering a targeted daphnetin delivery system to enhance spinal cord injury treatment effectiveness. — PubMed · 2025 · Journal Article
- Effects of Clobetasol in an Aging Mouse Model of Spinal Cord Hemisection. — PubMed · 2025 · Journal Article
- Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury. — PubMed · 2025 · Journal Article
- Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases. — PubMed · 2025 · Journal Article
- Integrating single-cell RNA sequencing and spatial multi-omics reveals the molecular signature of regeneration after spinal cord injury. — PubMed · 2025 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1037078 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 4 · this programme has 1301 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("macrophage" OR "macrophage polarization" OR "autologous incubated macrophage") - Crossref
spinal cord injury macrophage macrophage polarization - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Macrophages"[MeSH Terms] OR "macrophage"[Title/Abstract] OR "macrophage polarization"[Title/Abstract] OR "autologous incubated macrophage"[Title/Abstract])