A subject this map covers
Macrophage therapy and polarisation
Part of: Inflammation and immune response
What belongs here
Delivering or reprogramming macrophages to change the character of inflammation at the injury.
What does not belong here, however close it looks
Describing what macrophages do without intervening is mechanism, not therapy; such a record stays in the parent concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 265 records · 1967–2026
- Indexed as work in animals: 781 records · 1966–2026
- Indexed as laboratory work: 41 records · 1988–2026
- The source has not said who or what was studied: 211 records · 1999–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1298 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- In Situ Cross-Linkable Hyaluronic-Ferulic Acid Conjugate Containing Bucladesine Nanoparticles Promotes Neural Regeneration after Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Targeted delivery of CD163(+) macrophage-derived small extracellular vesicles via RGD peptides promote vascular regeneration and stabilization after spinal cord injury. — PubMed · 2023 · Journal Article
- Hydralazine Promotes Central Nervous System Recovery after Spinal Cord Injury by Suppressing Oxidative Stress and Inflammation through Macrophage Regulation. — PubMed · 2023 · Journal Article The source marks this record as retracted.
- Protein arginine methyltransferase 8 regulates ferroptosis and macrophage polarization in spinal cord injury via glial cell-derived neurotrophic factor. — PubMed · 2023 · Journal Article
- Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis. — PubMed · 2023 · Journal Article
- Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3/JAK2/STAT3 axis and improve the outcome of spinal cord injury. — PubMed · 2023 · Journal Article
- Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. — PubMed · 2023 · Journal Article
- Self-delivering mRNA inhibitors of MK2 improve outcomes after spinal cord injury. — PubMed · 2023 · Journal Article
- Sodium houttuyfonate exerts its neuroprotection effect by inhibiting the M1 microglia polarization in a TLR4/NF-κB signal pathway. — PubMed · 2023 · Journal Article
- Adipose-Derived Mesenchymal Stromal Cell Transplantation for Severe Spinal Cord Injury: Functional Improvement Supported by Angiogenesis and Neuroprotection. — PubMed · 2023 · Journal Article
- Chronic intermittent hypobaric hypoxia ameliorates osteoporosis after spinal cord injury through balancing osteoblast and osteoclast activities in rats. — PubMed · 2023 · Journal Article
- Architecture-Engineered Electrospinning Cascade Regulates Spinal Microenvironment to Promote Nerve Regeneration. — PubMed · 2023 · Journal Article
- Curcumin-Primed Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Improve Motor Functional Recovery of Mice with Complete Spinal Cord Injury by Reducing Inflammation and Enhancing Axonal Regeneration. — PubMed · 2023 · Journal Article
- Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury. — PubMed · 2023 · Journal Article
- Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury. — PubMed · 2023 · Journal Article
- Engineering of M2 Macrophages-Derived Exosomes via Click Chemistry for Spinal Cord Injury Repair. — PubMed · 2023 · Journal Article
- Conditioned medium from bone marrow mesenchymal stem cells relieves spinal cord injury through suppression of Gal-3/NLRP3 and M1 microglia/macrophage polarization. — PubMed · 2023 · Journal Article
- Supramolecular Hydrogel Microspheres of Platelet-Derived Growth Factor Mimetic Peptide Promote Recovery from Spinal Cord Injury. — PubMed · 2023 · Journal Article
- The polarization of microglia and infiltrated macrophages in the injured mice spinal cords: a dynamic analysis. — PubMed · 2023 · Journal Article
- Macrophage Migration Inhibitory Factor Promotes Expression of Matrix Metalloproteinases 1 and 3 in Spinal Cord Astrocytes following Gecko Tail Amputation. — PubMed · 2023 · Journal Article
- Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury. — PubMed · 2023 · Journal Article
- Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury. — PubMed · 2023 · Journal Article
- Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury. — PubMed · 2023 · Journal Article
- Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis. — PubMed · 2023 · Journal Article
- Infiltrating circulating monocytes provide an important source of BMP4 at the early stage of spinal cord injury. — PubMed · 2023 · Journal Article
- Intrathecal minocycline does not block the adverse effects of repeated, intravenous morphine administration on recovery of function after SCI. — PubMed · 2023 · Journal Article
- Dopamine-modified chitosan hydrogel for spinal cord injury. — PubMed · 2022 · Journal Article
- Inflammatory Microenvironment-Responsive Nanomaterials Promote Spinal Cord Injury Repair by Targeting IRF5. — PubMed · 2022 · Journal Article
- Melittin regulates iron homeostasis and mediates macrophage polarization in rats with lumbar spinal stenosis. — PubMed · 2022 · Journal Article
- Codelivery of minocycline hydrochloride and dextran sulfate via bionic liposomes for the treatment of spinal cord injury. — PubMed · 2022 · Journal Article
- Morphine-induced changes in the function of microglia and macrophages after acute spinal cord injury. — PubMed · 2022 · Journal Article
- Astaxanthin ameliorates serum level and spinal expression of macrophage migration inhibitory factor following spinal cord injury. — PubMed · 2022 · Journal Article
- Genetic deletion of the glucocorticoid receptor in Cx(3)cr1(+) myeloid cells is neuroprotective and improves motor recovery after spinal cord injury. — PubMed · 2022 · Journal Article
- Therapeutic Effects of Azithromycin on Spinal Cord Injury in Male Wistar Rats: A Role for Inflammatory Pathways. — PubMed · 2022 · Journal Article
- Bioinformatics analysis identified apolipoprotein E as a hub gene regulating neuroinflammation in macrophages and microglia following spinal cord injury. — PubMed · 2022 · Journal Article
- Macrophages Treated with VEGF and PDGF Exert Paracrine Effects on Olfactory Ensheathing Cell Function. — PubMed · 2022 · Journal Article
- Fatty Acid-Binding Protein 4 Inhibition Promotes Locomotor and Autonomic Recovery in Rats following Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Microglia coordinate cellular interactions during spinal cord repair in mice. — PubMed · 2022 · Journal Article
- Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice. — PubMed · 2022 · Journal Article
- Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization. — PubMed · 2022 · Journal Article
- Mitochondrial-targeting antioxidant MitoQ modulates angiogenesis and promotes functional recovery after spinal cord injury. — PubMed · 2022 · Journal Article
- Single-cell sequencing reveals microglia induced angiogenesis by specific subsets of endothelial cells following spinal cord injury. — PubMed · 2022 · Journal Article
- [Effect of M2-like macrophage/microglia-derived mitochondria transplantation in treatment of mouse spinal cord injury]. — PubMed · 2022 · Journal Article
- BET protein inhibition promotes non-myeloid cell mediated neuroprotection after rodent spinal cord contusion. — PubMed · 2022 · Journal Article
- PBMSCs transplantation facilitates functional recovery after spinal cord injury by regulating microglia/macrophages plasticity. — PubMed · 2022 · Journal Article
- Thrombin acts as inducer of proinflammatory macrophage migration inhibitory factor in astrocytes following rat spinal cord injury. — PubMed · 2022 · Journal Article
- Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury. — PubMed · 2022 · Journal Article
- Ac-SDKP peptide improves functional recovery following spinal cord injury in a preclinical model. — PubMed · 2022 · Journal Article
- A Single Administration of Riluzole Applied Acutely After Spinal Cord Injury Attenuates Pro-inflammatory Activity and Improves Long-Term Functional Recovery in Rats. — PubMed · 2022 · Journal Article
- Macrophage polarization in vitro and in vivo modified by contact with fragmented chitosan hydrogel. — PubMed · 2022 · Journal Article
- Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages. — PubMed · 2022 · Journal Article
- Photobiomodulation Attenuates Neurotoxic Polarization of Macrophages by Inhibiting the Notch1-HIF-1α/NF-κB Signalling Pathway in Mice With Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Ultrasound stimulation improves inflammatory resolution, neuroprotection, and functional recovery after spinal cord injury. — PubMed · 2022 · Journal Article
- M1 macrophages impair tight junctions between endothelial cells after spinal cord injury. — PubMed · 2022 · Journal Article
- Glutathione-modified macrophage-derived cell membranes encapsulated metformin nanogels for the treatment of spinal cord injury. — PubMed · 2022 · Journal Article
- Myelin and non-myelin debris contribute to foamy macrophage formation after spinal cord injury. — PubMed · 2022 · Journal Article
- Inhibiting RGS1 attenuates secondary inflammation response and tissue degradation via the TLR/TRIF/NF-κB pathway in macrophage post spinal cord injury. — PubMed · 2022 · Journal Article
- A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury. — PubMed · 2022 · Journal Article
- Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway. — PubMed · 2021 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1037078 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 4 · this programme has 1301 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("macrophage" OR "macrophage polarization" OR "autologous incubated macrophage") - Crossref
spinal cord injury macrophage macrophage polarization - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Macrophages"[MeSH Terms] OR "macrophage"[Title/Abstract] OR "macrophage polarization"[Title/Abstract] OR "autologous incubated macrophage"[Title/Abstract])