A subject this map covers
Scar proteoglycan modulation
Part of: Glial scar and its remodelling
What belongs here
Acting on the scar’s inhibitory molecules or their receptors without enzymatic digestion.
What does not belong here, however close it looks
Enzymatic digestion is chondroitinase, a separate concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 84 records · 2000–2025
- Indexed as work in animals: 244 records · 1997–2026
- Indexed as laboratory work: 23 records · 2004–2021
- The source has not said who or what was studied: 68 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
419 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Transplantation of undifferentiated and induced human exfoliated deciduous teeth-derived stem cells promote functional recovery of rat spinal cord contusion injury model. — PubMed · 2012 · Journal Article
- Chondroitin sulfate: a key molecule in the brain matrix. — PubMed · 2012 · Journal Article
- [Cervical spinal cord injuries and respiratory insufficiency: a revolutionary treatment?]. — PubMed · 2012 · News
- Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury. — PubMed · 2012 · Journal Article
- Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. — PubMed · 2012 · Journal Article
- Regenerative medicine: drawing breath after spinal injury. — PubMed · 2011 · Comment
- Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair. — PubMed · 2011 · Journal Article
- Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium. — PubMed · 2010 · Journal Article
- Schwann cell migration is integrin-dependent and inhibited by astrocyte-produced aggrecan. — PubMed · 2010 · Journal Article
- Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury. — PubMed · 2010 · Journal Article
- NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury. — PubMed · 2009 · Journal Article
- Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. — PubMed · 2009 · Journal Article
- Axon regeneration in the peripheral and central nervous systems. — PubMed · 2009 · Journal Article
- Decorin promotes robust axon growth on inhibitory CSPGs and myelin via a direct effect on neurons. — PubMed · 2008 · Comparative Study
- [Strategies for axonal regeneration after spinal cord injury]. — PubMed · 2008 · Journal Article
- The role of extracellular matrix in CNS regeneration. — PubMed · 2007 · Journal Article
- Dynamic role of kallikrein 6 in traumatic spinal cord injury. — PubMed · 2006 · Comparative Study
- Characterization of non-neuronal elements within fibronectin mats implanted into the damaged adult rat spinal cord. — PubMed · 2006 · Journal Article
- The quest to repair the damaged spinal cord. — PubMed · 2006 · Journal Article
- Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. — PubMed · 2005 · Journal Article
- Gradual loss of myelin and formation of an astrocytic scar during Wallerian degeneration in the human spinal cord. — PubMed · 2004 · Journal Article
- Myelin molecules limiting nervous system plasticity. — PubMed · 2003 · Journal Article
- Chondroitin sulphate proteoglycans in the CNS injury response. — PubMed · 2002 · Journal Article
- Schwannosis: role of gliosis and proteoglycan in human spinal cord injury. — PubMed · 2000 · Journal Article
Indexed as work in animals
- Size-dependent alterations in phrenic motor neuron perineuronal nets following cervical spinal hemisection. — PubMed · 2026 · Journal Article
- Role of COL1A1 and CD44 in Modulating JAK1/STAT3-Mediated Autophagy for Spinal Cord Injury Recovery. — PubMed · 2026 · Journal Article
- Time-dependent adaptations of damaged neurons and their microenvironment in the regenerating adult zebrafish spinal cord. — PubMed · 2026 · Journal Article
- LPS Pre-Conditioned Olfactory Ensheathing Cells Derived Extracellular Vesicle Regulate Microglia Polarization Through mir-1224/CD44/SLC7A11 Axis Following Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors. — PubMed · 2026 · Journal Article
- Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats. — PubMed · 2026 · Journal Article
- CD44 Knockout Alters the Cellular Response and Improves Locomotor Outcome After Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Disrupting CSPG-Driven Microglia-Astrocyte Crosstalk Enables Scar-Free Repair in Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Molecular Changes in CSPG and Glial Scar Markers in Response to Subpial Chondroitinase ABC Treatment Following Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Regulatory T cells attenuate astrogliosis via IL-10/STAT3/PKC/vimentin signaling and promote neurological recovery after spinal cord injury. — PubMed · 2026 · Journal Article
- Removal or inhibition of transglutaminase 2 decreases cellular stress, supporting tissue preservation, and recovery after SCI. — PubMed · 2025 · Journal Article
- Meflin/Islr is a marker of fibroblasts that arise in fibrotic regions after spinal cord injury. — PubMed · 2025 · Journal Article
- Combined loss of brevican, neurocan, tenascin-C and tenascin-R leads to impaired fear retrieval due to perineuronal net loss. — PubMed · 2025 · Journal Article
- Glycolytic metabolism modulation on spinal neuroinflammation and vital functions following cervical spinal cord injury. — PubMed · 2025 · Journal Article
- Inhibition of CSPG-PTPσ Activates Autophagy Flux and Lysosome Fusion, Aids Axon and Synaptic Reorganization in Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury. — PubMed · 2024 · Journal Article
- Photobiomodulation Increases M2-Type Polarization of Macrophages by Inhibiting Versican Production After Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Schwann Cell-Derived Exosomes Induced Axon Growth after Spinal Cord Injury by Decreasing PTP-σ Activation on CSPGs via the Rho/ROCK Pathway. — PubMed · 2024 · Journal Article
- Calycosin promotes axon growth by inhibiting PTPRS and alleviates spinal cord injury. — PubMed · 2024 · Journal Article
- Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review. — PubMed · 2024 · Journal Article
- Long-Acting Heterodimeric Paclitaxel-Idebenone Prodrug-Based Nanomedicine Promotes Functional Recovery after Spinal Cord Injury. — PubMed · 2024 · Journal Article
- microRNA-143 targets SIRT2 to mediate the histone acetylation of PLAUR and modulates functions of astrocytes in spinal cord injury. — PubMed · 2024 · Journal Article
- PD-1 deficiency aggravates spinal cord injury by regulating the reprogramming of NG2 glia and activating the NgR/RhoA/ROCK signaling pathway. — PubMed · 2024 · Journal Article
- Electroacupuncture promotes the repair of the damaged spinal cord in mice by mediating neurocan-perineuronal net. — PubMed · 2024 · Journal Article
- Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury. — PubMed · 2023 · Journal Article
- Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition. — PubMed · 2023 · Journal Article
- Identification of Neurocan and Phosphacan as Early Biomarkers for Open Neural Tube Defects. — PubMed · 2023 · Journal Article
- AAV Vector Mediated Delivery of NG2 Function Neutralizing Antibody and Neurotrophin NT-3 Improves Synaptic Transmission, Locomotion, and Urinary Tract Function after Spinal Cord Contusion Injury in Adult Rats. — PubMed · 2023 · Journal Article
- Fidgetin impacts axonal growth and branching in a local mTOR signal dependent manner. — PubMed · 2023 · Journal Article
- 5-Fluorouracil reduces the fibrotic scar via inhibiting matrix metalloproteinase 9 and stabilizing microtubules after spinal cord injury. — PubMed · 2022 · Journal Article
- A Localized Materials-Based Strategy to Non-Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model. — PubMed · 2022 · Journal Article
- Development of Neurogenic Detrusor Overactivity after Thoracic Spinal Cord Injury Is Accompanied by Time-Dependent Changes in Lumbosacral Expression of Axonal Growth Regulators. — PubMed · 2022 · Journal Article
- Regulation of perineuronal net components in the synaptic bouton vicinity on lumbar α-motoneurons in the rat after spinalization and locomotor training: New insights from spatio-temporal changes in gene, protein expression and WFA labeling. — PubMed · 2022 · Journal Article
- Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury. — PubMed · 2022 · Journal Article
- Water Treadmill Training Ameliorates Neurite Outgrowth Inhibition Associated with NGR/RhoA/ROCK by Inhibiting Astrocyte Activation following Spinal Cord Injury. — PubMed · 2022 · Journal Article
- Inhibition of Autophagy Flux Promotes Secretion of Chondroitin Sulfate Proteoglycans in Primary Rat Astrocytes. — PubMed · 2021 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1527414 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 404 · this programme has 404 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("chondroitin sulfate proteoglycan" OR "CSPG receptor" OR "PTPsigma peptide") - Crossref
spinal cord injury chondroitin sulfate proteoglycan CSPG receptor - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Chondroitin Sulfate Proteoglycans"[MeSH Terms] OR "chondroitin sulfate proteoglycan"[Title/Abstract] OR "CSPG receptor"[Title/Abstract] OR "PTPsigma peptide"[Title/Abstract])