A subject this map covers
Scar proteoglycan modulation
Part of: Glial scar and its remodelling
What belongs here
Acting on the scar’s inhibitory molecules or their receptors without enzymatic digestion.
What does not belong here, however close it looks
Enzymatic digestion is chondroitinase, a separate concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 84 records · 2000–2025
- Indexed as work in animals: 244 records · 1997–2026
- Indexed as laboratory work: 23 records · 2004–2021
- The source has not said who or what was studied: 68 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
419 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Chronic alterations in the cellular composition of spinal cord white matter following contusion injury. — PubMed · 2005 · Journal Article
- Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord. — PubMed · 2004 · Journal Article
- Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord. — PubMed · 2004 · Journal Article
- Upregulation of CD44 expression in the spinal cords of rats with clip compression injury. — PubMed · 2004 · Comparative Study
- Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129X1/SvJ) with a diminished inflammatory response. — PubMed · 2004 · Comparative Study
- NG2 proteoglycan expression in the peripheral nervous system: upregulation following injury and comparison with CNS lesions. — PubMed · 2004 · Comparative Study
- Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. — PubMed · 2004 · Journal Article
- PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. — PubMed · 2004 · Journal Article
- Present situation and future aspects of spinal cord regeneration. — PubMed · 2004 · Journal Article
- Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Surgical repair of the injured spinal cord using biodegradable polymer implants to facilitate axon regeneration. — PubMed · 2004 · Journal Article
- The effects of treatment with antibodies to transforming growth factor beta1 and beta2 following spinal cord damage in the adult rat. — PubMed · 2004 · Journal Article
- Steroid effects on glial cells: detrimental or protective for spinal cord function? — PubMed · 2003 · Comparative Study
- Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice. — PubMed · 2003 · Journal Article
- Activated/effector CD4+ T cells exacerbate acute damage in the central nervous system following traumatic injury. — PubMed · 2003 · Comparative Study
- The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. — PubMed · 2003 · Journal Article
- Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. — PubMed · 2003 · Journal Article
- Changes in neurocan expression in the distal spinal cord stump following complete cord transection: a comparison between infant and adult rats. — PubMed · 2003 · Comparative Study
- Increased expression of the putative axon growth-repulsive extracellular matrix molecule, keratan sulphate proteoglycan, following traumatic injury of the adult rat spinal cord. — PubMed · 2002 · Journal Article
- Rho signaling pathway targeted to promote spinal cord repair. — PubMed · 2002 · Journal Article
- Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord. — PubMed · 2002 · Journal Article
- [New treatments for spinal cord injuries]. — PubMed · 2002 · Journal Article
- Spinal cord injury elicits expression of keratan sulfate proteoglycans by macrophages, reactive microglia, and oligodendrocyte progenitors. — PubMed · 2002 · Journal Article
- Intrathecal administration of epidermal growth factor and fibroblast growth factor 2 promotes ependymal proliferation and functional recovery after spinal cord injury in adult rats. — PubMed · 2002 · Journal Article
- Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury. — PubMed · 2001 · Journal Article
- MMP-related gelatinase activity is strongly induced in scar tissue of injured adult spinal cord and forms pathways for ingrowing neurites. — PubMed · 2001 · Journal Article
- Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. — PubMed · 2001 · Journal Article
- Inhibitory proteoglycan immunoreactivity is higher at the caudal than the rostral Schwann cell graft-transected spinal cord interface. — PubMed · 2001 · Journal Article
- Axonal and nonneuronal cell responses to spinal cord injury in mice lacking glial fibrillary acidic protein. — PubMed · 1997 · Journal Article
Indexed as laboratory work
- Select neurotrophins promote oligodendrocyte progenitor cell process outgrowth in the presence of chondroitin sulfate proteoglycans. — PubMed · 2021 · Journal Article
- Time-Course Changes of Extracellular Matrix Encoding Genes Expression Level in the Spinal Cord Following Contusion Injury-A Data-Driven Approach. — PubMed · 2021 · Journal Article
- TGF-β Secretion by M2 Macrophages Induces Glial Scar Formation by Activating Astrocytes In Vitro. — PubMed · 2019 · Journal Article
- RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth. — PubMed · 2017 · Journal Article
- Non-viral xylosyltransferase-1 siRNA delivery as an effective alternative to chondroitinase in an in vitro model of reactive astrocytes. — PubMed · 2016 · Journal Article
- Dynamic behaviors of astrocytes in chemically modified fibrin and collagen hydrogels. — PubMed · 2016 · Journal Article
- Nebulized solvent ablation of aligned PLLA fibers for the study of neurite response to anisotropic-to-isotropic fiber/film transition (AFFT) boundaries in astrocyte-neuron co-cultures. — PubMed · 2015 · Journal Article
- Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. — PubMed · 2014 · Journal Article
- A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin. — PubMed · 2013 · Comparative Study
- Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury. — PubMed · 2012 · Journal Article
- The roles of neuronal and glial precursors in overcoming chondroitin sulfate proteoglycan inhibition. — PubMed · 2012 · Comparative Study
- Neuronal glycosylation differentials in normal, injured and chondroitinase-treated environments. — PubMed · 2012 · Journal Article
- Minimal essential length of Clostridium botulinum C3 peptides to enhance neuronal regenerative growth and connectivity in a non-enzymatic mode. — PubMed · 2012 · Journal Article
- Promoting survival, migration, and integration of transplanted Schwann cells by over-expressing polysialic acid. — PubMed · 2011 · Journal Article
- The effects of combining chondroitinase ABC and NEP1-40 on the corticospinal axon growth in organotypic co-cultures. — PubMed · 2010 · Journal Article
- Neurite outgrowth of neural progenitors in presence of inhibitory proteoglycans. — PubMed · 2010 · Journal Article
- Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. — PubMed · 2010 · Journal Article
- Beta-catenin signaling increases in proliferating NG2+ progenitors and astrocytes during post-traumatic gliogenesis in the adult brain. — PubMed · 2010 · Journal Article
- Fibrin-based tissue engineering scaffolds enhance neural fiber sprouting and delay the accumulation of reactive astrocytes at the lesion in a subacute model of spinal cord injury. — PubMed · 2010 · Journal Article
- Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter. — PubMed · 2008 · Journal Article
- Mixed primary culture and clonal analysis provide evidence that NG2 proteoglycan-expressing cells after spinal cord injury are glial progenitors. — PubMed · 2007 · Journal Article
- Simvastatin promotes neurite outgrowth in the presence of inhibitory molecules found in central nervous system injury. — PubMed · 2006 · Journal Article
- Studies on the development and behavior of the dystrophic growth cone, the hallmark of regeneration failure, in an in vitro model of the glial scar and after spinal cord injury. — PubMed · 2004 · Journal Article
The source has not said who or what was studied
- Antigliotic guiding regenerative gel: a bioactive hydrogel platform for peripheral nerve and spinal cord repair. — PubMed · 2026 · Journal Article
- NG2 Glia and Cellular Crosstalk in Health and Disease: Focus on Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Widespread AAV-mediated CSPG digestion impairs functional recovery after cervical spinal cord injury — Crossref · 2026 · posted-content
- GIP Affects Neuronal Microtubule Acetylation by Regulating αTAT1 Degradation. — PubMed · 2026 · Journal Article
- Spinal cord transection repair occurs when Nestin+ cells differentiate into neurons within a taxol-collagen-enhanced microenvironment in mice. — PubMed · 2025 · Journal Article
- Pharmacological intervention for chronic phase of spinal cord injury. — PubMed · 2025 · Journal Article
- Chondroitin sulfate in invertebrate development — Crossref · 2024 · journal-article
- Hepatocyte Growth Factor Delivery to Injured Cervical Spinal Cord Using an Engineered Biomaterial Protects Respiratory Neural Circuitry and Preserves Functional Diaphragm Innervation. — PubMed · 2024 · Journal Article
- Corrigendum: Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury. — PubMed · 2024 · Published Erratum
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1527414 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 404 · this programme has 404 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("chondroitin sulfate proteoglycan" OR "CSPG receptor" OR "PTPsigma peptide") - Crossref
spinal cord injury chondroitin sulfate proteoglycan CSPG receptor - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Chondroitin Sulfate Proteoglycans"[MeSH Terms] OR "chondroitin sulfate proteoglycan"[Title/Abstract] OR "CSPG receptor"[Title/Abstract] OR "PTPsigma peptide"[Title/Abstract])