A subject this map covers
Scar proteoglycan modulation
Part of: Glial scar and its remodelling
What belongs here
Acting on the scar’s inhibitory molecules or their receptors without enzymatic digestion.
What does not belong here, however close it looks
Enzymatic digestion is chondroitinase, a separate concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 84 records · 2000–2025
- Indexed as work in animals: 244 records · 1997–2026
- Indexed as laboratory work: 23 records · 2004–2021
- The source has not said who or what was studied: 68 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
419 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Embryonic stem cells promote motor recovery and affect inflammatory cell infiltration in spinal cord injured mice. — PubMed · 2010 · Journal Article
- Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. — PubMed · 2010 · Journal Article
- Gait analysis of spinal cord injured rats after delivery of chondroitinase ABC and adult olfactory mucosa progenitor cell transplantation. — PubMed · 2010 · Journal Article
- Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice. — PubMed · 2010 · Journal Article
- Adult NG2+ cells are permissive to neurite outgrowth and stabilize sensory axons during macrophage-induced axonal dieback after spinal cord injury. — PubMed · 2010 · Comparative Study
- Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord. — PubMed · 2009 · Journal Article
- Enrichment of rat oligodendrocyte progenitor cells by magnetic cell sorting. — PubMed · 2009 · Journal Article
- Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. — PubMed · 2009 · Journal Article
- PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. — PubMed · 2009 · Journal Article
- Overcoming macrophage-mediated axonal dieback following CNS injury. — PubMed · 2009 · Journal Article
- Shengmai-san-mediated enhancement of regenerative responses of spinal cord axons after injury in rats. — PubMed · 2009 · Journal Article
- Postinjury niches induce temporal shifts in progenitor fates to direct lesion repair after spinal cord injury. — PubMed · 2009 · Journal Article
- GM-CSF inhibits glial scar formation and shows long-term protective effect after spinal cord injury. — PubMed · 2009 · Journal Article
- Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord. — PubMed · 2008 · Journal Article
- A novel diketopiperazine stimulates sprouting of spinally projecting axons. — PubMed · 2008 · Journal Article
- A new in vitro model of the glial scar inhibits axon growth. — PubMed · 2008 · Journal Article
- Chondroitinase ABC-mediated plasticity of spinal sensory function. — PubMed · 2008 · Journal Article
- Statins decrease chondroitin sulfate proteoglycan expression and acute astrocyte activation in central nervous system injury. — PubMed · 2008 · Journal Article
- Robust axonal growth and a blunted macrophage response are associated with impaired functional recovery after spinal cord injury in the MRL/MpJ mouse. — PubMed · 2008 · Comparative Study
- Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes. — PubMed · 2008 · Comparative Study
- Chondroitin-4-sulfation negatively regulates axonal guidance and growth. — PubMed · 2008 · Journal Article
- Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS. — PubMed · 2008 · Journal Article
- Role of Rho kinase pathway in chondroitin sulfate proteoglycan-mediated inhibition of neurite outgrowth in PC12 cells. — PubMed · 2008 · Journal Article
- Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat. — PubMed · 2008 · Journal Article
- Microfluidic-based strip assay for testing the effects of various surface-bound inhibitors in spinal cord injury. — PubMed · 2008 · Journal Article
- Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. — PubMed · 2008 · Journal Article
- tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2. — PubMed · 2008 · Journal Article
- Chondroitin sulfate proteoglycans in spinal cord contusion injury and the effects of chondroitinase treatment. — PubMed · 2007 · Journal Article
- Analysis of axonal regeneration in the central and peripheral nervous systems of the NG2-deficient mouse. — PubMed · 2007 · Journal Article
- Sensory afferents regenerated into dorsal columns after spinal cord injury remain in a chronic pathophysiological state. — PubMed · 2007 · Journal Article
- Prominent oligodendrocyte genesis along the border of spinal contusion lesions. — PubMed · 2007 · Journal Article
- Glial cell loss, proliferation and replacement in the contused murine spinal cord. — PubMed · 2007 · Journal Article
- Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans. — PubMed · 2007 · Journal Article
- Erythropoietin-mediated preservation of the white matter in rat spinal cord injury. — PubMed · 2007 · Journal Article
- Characterization of retinaldehyde dehydrogenase-2 induction in NG2-positive glia after spinal cord contusion injury. — PubMed · 2007 · Journal Article
- Axon regeneration through scars and into sites of chronic spinal cord injury. — PubMed · 2007 · Journal Article
- Phenotypic changes in NG2+ cells after spinal cord injury. — PubMed · 2006 · Journal Article
- Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. — PubMed · 2006 · Journal Article
- Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. — PubMed · 2006 · Journal Article
- Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. — PubMed · 2006 · Journal Article
- Degradation of chondroitin sulfate proteoglycans potentiates transplant-mediated axonal remodeling and functional recovery after spinal cord injury in adult rats. — PubMed · 2006 · Comparative Study
- Antibodies against the NG2 proteoglycan promote the regeneration of sensory axons within the dorsal columns of the spinal cord. — PubMed · 2006 · Comparative Study
- Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. — PubMed · 2006 · Comparative Study
- NG2 colocalizes with axons and is expressed by a mixed cell population in spinal cord lesions. — PubMed · 2006 · Comparative Study
- Decorin promotes plasminogen/plasmin expression within acute spinal cord injuries and by adult microglia in vitro. — PubMed · 2006 · Journal Article
- Expression of two temporally distinct microglia-related gene clusters after spinal cord injury. — PubMed · 2006 · Journal Article
- Progesterone increases the expression of myelin basic protein and the number of cells showing NG2 immunostaining in the lesioned spinal cord. — PubMed · 2006 · Journal Article
- Acute and delayed transplantation of olfactory ensheathing cells promote partial recovery after complete transection of the spinal cord. — PubMed · 2006 · Journal Article
- In situ gelling hydrogels for conformal repair of spinal cord defects, and local delivery of BDNF after spinal cord injury. — PubMed · 2006 · Journal Article
- Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury. — PubMed · 2005 · Comparative Study
- Increase of NG2-positive cells associated with radial glia following traumatic spinal cord injury in adult rats. — PubMed · 2005 · Journal Article
- Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. — PubMed · 2005 · Comparative Study
- Early profiles of axonal growth and astroglial response after spinal cord hemisection and implantation of Schwann cell-seeded guidance channels in adult rats. — PubMed · 2005 · Comparative Study
- Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord. — PubMed · 2005 · Comparative Study
- Regulation of neuronal and glial galectin-1 expression by peripheral and central axotomy of rat primary afferent neurons. — PubMed · 2005 · Comparative Study
- Embryonic radial glia bridge spinal cord lesions and promote functional recovery following spinal cord injury. — PubMed · 2005 · Comparative Study
- Differential responses of spinal axons to transection: influence of the NG2 proteoglycan. — PubMed · 2005 · Comparative Study
- X-irradiation reduces lesion scarring at the contusion site of adult rat spinal cord. — PubMed · 2005 · Journal Article
- Corticospinal regeneration into lumbar grey matter correlates with locomotor recovery after complete spinal cord transection and repair with peripheral nerve grafts, fibroblast growth factor 1, fibrin glue, and spinal fusion. — PubMed · 2005 · Comparative Study
- Retinoic acid synthesis by a population of NG2-positive cells in the injured spinal cord. — PubMed · 2005 · Comparative Study
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1527414 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 404 · this programme has 404 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("chondroitin sulfate proteoglycan" OR "CSPG receptor" OR "PTPsigma peptide") - Crossref
spinal cord injury chondroitin sulfate proteoglycan CSPG receptor - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Chondroitin Sulfate Proteoglycans"[MeSH Terms] OR "chondroitin sulfate proteoglycan"[Title/Abstract] OR "CSPG receptor"[Title/Abstract] OR "PTPsigma peptide"[Title/Abstract])