A subject this map covers
Rho/ROCK inhibition
Part of: Axon growth and regeneration
What belongs here
Drugs that switch off the internal pathway collapsing the growth cone.
What does not belong here, however close it looks
The same drugs in cardiology or vasospasm do not belong here.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 38 records · 2004–2024
- Indexed as work in animals: 47 records · 2002–2026
- Indexed as laboratory work: 2 records · 2012–2017
- The source has not said who or what was studied: 49 records · 1966–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
136 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- ROCK inhibition with fasudil promotes early functional recovery of spinal cord injury in rats by enhancing microglia phagocytosis. — PubMed · 2016 · Journal Article
- Beneficial effects of local profound hypothermia and the possible mechanism after experimental spinal cord injury in rats. — PubMed · 2016 · Journal Article
- Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway. — PubMed · 2015 · Journal Article
- AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury. — PubMed · 2015 · Journal Article
- Infralimbic cortex Rho-kinase inhibition causes antidepressant-like activity in rats. — PubMed · 2015 · Journal Article
- RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain. — PubMed · 2015 · Journal Article
- Ibuprofen protects ventilator-induced lung injury by downregulating Rho-kinase activity in rats. — PubMed · 2014 · Journal Article
- Inactivation of the Rho-ROCK signaling pathway to promote neurologic recovery after spinal cord injuries in rats. — PubMed · 2013 · Journal Article
- 17β-Estradiol inhibits apoptotic cell death of oligodendrocytes by inhibiting RhoA-JNK3 activation after spinal cord injury. — PubMed · 2012 · Journal Article
- The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of Rho and ROCK inhibitors on neurite outgrowth and myelination. — PubMed · 2012 · Journal Article
- The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes. — PubMed · 2011 · Journal Article
- Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation. — PubMed · 2010 · Journal Article
- Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice. — PubMed · 2010 · Journal Article
- Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits. — PubMed · 2010 · Journal Article
- Rho-associated kinase II (ROCKII) limits axonal growth after trauma within the adult mouse spinal cord. — PubMed · 2009 · Journal Article
- Targeting a dominant negative rho kinase to neurons promotes axonal outgrowth and partial functional recovery after rat rubrospinal tract lesion. — PubMed · 2009 · Journal Article
- Role of Rho kinase pathway in chondroitin sulfate proteoglycan-mediated inhibition of neurite outgrowth in PC12 cells. — PubMed · 2008 · Journal Article
- Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule. — PubMed · 2008 · Journal Article
- Wallerian degeneration involves Rho/Rho-kinase signaling. — PubMed · 2005 · Journal Article
- Lesional RhoA+ cell numbers are suppressed by anti-inflammatory, cyclooxygenase-inhibiting treatment following subacute spinal cord injury. — PubMed · 2004 · Journal Article
- Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats. — PubMed · 2004 · Journal Article
- The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. — PubMed · 2003 · Journal Article
- Rho kinase inhibition enhances axonal regeneration in the injured CNS. — PubMed · 2003 · Journal Article
- A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat. — PubMed · 2003 · Journal Article
- Rho signaling pathway targeted to promote spinal cord repair. — PubMed · 2002 · Journal Article
Indexed as laboratory work
- Regulation of RhoA by STAT3 coordinates glial scar formation. — PubMed · 2017 · Journal Article
- Optimized protocol for derivation of human embryonic stem cell lines. — PubMed · 2012 · Journal Article
The source has not said who or what was studied
- A nasally delivered ferroptosis nano-inhibitor for spinal cord injury repair — Crossref · 2026 · journal-article
- Electrochemiluminescence-enhanced mesoporous composite enabling sensitive deoxynivalenol detection and nano-delivery of a ROCK inhibitor for spinal cord injury — Crossref · 2026 · journal-article
- Potential Pharmacologic Treatments in Spinal Cord Injury: A Narrative Review. — PubMed · 2025 · Journal Article
- Candida parapsilosis Fungemia in a Patient With Spinal Cord Injury on Sodium-Glucose Cotransporter-2 Inhibitor Therapy: A Case Report — Crossref · 2025 · journal-article
- Suppression of the Growth Inhibitor Nogo-A in Spinal Cord Injury: Preclinical Basis and First Clinical Studies — Crossref · 2025 · book-chapter
- PKR inhibitor protects spinal cord injury through mitigating endoplasmic reticulum stress and pyroptosis — Crossref · 2024 · journal-article
- CK2 inhibitor DMAT ameliorates spinal cord injury by increasing autophagy and inducing anti-inflammatory microglial polarization — Crossref · 2023 · journal-article
- Effect of Rho-Rock Signaling Pathway Block-er on Neurological Recovery in Rats with Spinal Cord Injury — Crossref · 2023 · journal-article
- SGLT2 Inhibitor Regulates Ketone Body Metabolism Via Inter-Organ Crosstalk to Promote the Recovery of Spinal Cord Injury — Crossref · 2023 · posted-content
- The Effect of PIN1 Inhibitor Juglone on the Spinal Cord after Acute Spinal Cord Injury (ASCI) and Its Mechanism of Action: An Animal Study on Rats — Crossref · 2022 · journal-article
- Transplantation of Human-Fetal-Spinal-Cord-Derived NPCs Primed with a Polyglutamate-Conjugated Rho/Rock Inhibitor in Acute Spinal Cord Injury — Crossref · 2022 · journal-article
- Correction: Rho Kinase Inhibitor Y27632 Improves Recovery After Spinal Cord Injury by Shifting Astrocyte Phenotype and Morphology via the ROCK/NF-?B/C3 Pathway — Crossref · 2022 · journal-article
- Rho Kinase Inhibitor Y27632 Improves Recovery After Spinal Cord Injury by Shifting Astrocyte Phenotype and Morphology via the ROCK/NF-κB/C3 Pathway — Crossref · 2022 · journal-article
- MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury — Crossref · 2022 · journal-article
- The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats — Crossref · 2021 · journal-article
- Rho/ROCK Pathway and Noncoding RNAs: Implications in Ischemic Stroke and Spinal Cord Injury — Crossref · 2021 · journal-article
- Pharmacologic and Regenerative Cell Therapy for Spinal Cord Injury: WFNS Spine Committee Recommendations. — PubMed · 2020 · Journal Article
- Evaluation of PTEN Inhibitor Following Spinal Cord Injury on Recovery of Voiding Efficiency and Motor Function Observed by Regeneration in Spinal Cord — Crossref · 2020 · journal-article
- Exosome-Mediated siRNA pool Inhibits Axonal Growth Inhibitor in Cortical Neurons of Spinal Cord Injury in Rats — Crossref · 2020 · posted-content
- Role of Smad3 inhibitor and the pyroptosis pathway in spinal cord injury — Crossref · 2020 · journal-article
- Inhibiting an inhibitor: a decoy to recover dexterity after spinal cord injury — Crossref · 2020 · journal-article
- Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility. — PubMed · 2020 · Journal Article
- The mechanism of electroacupuncture for treating spinal cord injury rats by mediating Rho/Rho-associated kinase signaling pathway — Crossref · 2019 · journal-article
- The blocking of Rho-ROCK signalling pathway significantly improve functional outcome after spinal cord compression: Effect of Rho-A-kinase inhibitor Y-27632 vs acute Atorvastatin treatment — Crossref · 2018 · posted-content
- Rho Inhibitor VX-210 in Acute Traumatic Subaxial Cervical Spinal Cord Injury: Design of the SPinal Cord Injury Rho INhibition InvestiGation (SPRING) Clinical Trial — Crossref · 2018 · journal-article
- Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury — Crossref · 2018 · journal-article
- Neuroprotective Effects of Fasudil, a Rho-Kinase Inhibitor, After Spinal Cord Ischemia and Reperfusion in Rats — Crossref · 2018 · journal-article
- Promising neuroprotective strategies for traumatic spinal cord injury with a focus on the differential effects among anatomical levels of injury. — PubMed · 2017 · Journal Article
- The relation between neurite growth inhibitor factor and spinal cord injury — Crossref · 2017 · journal-article
- STAT1 inhibitor alleviates spinal cord injury by decreasing apoptosis — Crossref · 2016 · journal-article
- Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. — PubMed · 2015 · Journal Article
- Rho-ROCK Inhibition in the Treatment of Spinal Cord Injury — Crossref · 2014 · journal-article
- Cervical spinal cord injury: tailoring clinical trial endpoints to reflect meaningful functional improvements. — PubMed · 2014 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 4 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1341389 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 102 · this programme has 102 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("Rho inhibitor" OR "ROCK inhibitor" OR "Cethrin") - Crossref
spinal cord injury Rho inhibitor ROCK inhibitor - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("rho-Associated Kinases"[MeSH Terms] OR "Rho inhibitor"[Title/Abstract] OR "ROCK inhibitor"[Title/Abstract] OR "Cethrin"[Title/Abstract])