A subject this map covers
Rho/ROCK inhibition
Part of: Axon growth and regeneration
What belongs here
Drugs that switch off the internal pathway collapsing the growth cone.
What does not belong here, however close it looks
The same drugs in cardiology or vasospasm do not belong here.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 38 records · 2004–2024
- Indexed as work in animals: 47 records · 2002–2026
- Indexed as laboratory work: 2 records · 2012–2017
- The source has not said who or what was studied: 49 records · 1966–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
136 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Pharmacologic Therapy for Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors. — PubMed · 2022 · Journal Article
- Strategies to neutralize RhoA/ROCK pathway after spinal cord injury. — PubMed · 2021 · Journal Article
- A Randomized Controlled Trial of Local Delivery of a Rho Inhibitor (VX-210) in Patients with Acute Traumatic Cervical Spinal Cord Injury. — PubMed · 2021 · Clinical Trial, Phase II
- Role of Rho-associated coiled-coil containing protein kinase in the spinal cord injury induced neuropathic pain. — PubMed · 2021 · Journal Article
- Novel inhibitors of Rho-kinase mediated neuroinflammatory pathways and their potential application in recovery of injured spinal cord. — PubMed · 2020 · Journal Article
- Assessment and management of acute spinal cord injury: From point of injury to rehabilitation. — PubMed · 2017 · Case Reports
- Traumatic Spinal Cord Injury-Repair and Regeneration. — PubMed · 2017 · Journal Article
- Predicting Recruitment Feasibility for Acute Spinal Cord Injury Clinical Trials in Canada Using National Registry Data. — PubMed · 2017 · Journal Article
- Mevalonate Cascade and Small Rho GTPase in Spinal Cord Injury. — PubMed · 2017 · Journal Article
- Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats. — PubMed · 2016 · Journal Article
- Acute Spinal Cord Injury. — PubMed · 2015 · Journal Article
- Cethrin in Acute Cervical Spinal Cord Injury — ClinicalTrials.gov · 2015 · Interventional · Withdrawn
- Recent advances in the pharmacologic treatment of spinal cord injury. — PubMed · 2015 · Journal Article
- Fasudil reduces GFAP expression after hypoxic injury. — PubMed · 2014 · Journal Article
- Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis. — PubMed · 2014 · Journal Article
- Analysis of recruitment and outcomes in the phase I/IIa Cethrin clinical trial for acute spinal cord injury. — PubMed · 2013 · Clinical Trial, Phase I
- Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury — ClinicalTrials.gov · 2013 · Interventional · Completed
- Rho as a target to promote repair: translation to clinical studies with cethrin. — PubMed · 2013 · Journal Article
- Neuroproteomics approach and neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration and neurotrauma. — PubMed · 2012 · Journal Article
- [Physiopathology of overactive bladder syndrome]. — PubMed · 2012 · English Abstract
- Rho signaling and axon regeneration. — PubMed · 2012 · Journal Article
- A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. — PubMed · 2011 · Clinical Trial, Phase I
- Spinal cord injury: a systematic review of current treatment options. — PubMed · 2011 · Journal Article
- Emerging repair, regeneration, and translational research advances for spinal cord injury. — PubMed · 2010 · Journal Article
- Pharmacological approaches to induce neuroregeneration in spinal cord injury: an overview. — PubMed · 2009 · Journal Article
- Spinal cord injury and neural repair: focus on neuroregenerative approaches for spinal cord injury. — PubMed · 2009 · Journal Article
- Inflammation: beneficial or detrimental after spinal cord injury? — PubMed · 2008 · Journal Article
- Rho-ROCK inhibitors for the treatment of CNS injury. — PubMed · 2007 · Journal Article
- Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II. — PubMed · 2007 · Journal Article
- Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. — PubMed · 2007 · Journal Article
- Update on the treatment of spinal cord injury. — PubMed · 2007 · Journal Article
- Recent patents on Rho signaling pathway as therapeutic target for cardiovascular diseases. — PubMed · 2006 · Journal Article
- Pharmacological approaches to repair the injured spinal cord. — PubMed · 2006 · Journal Article
- Rho kinase, a promising drug target for neurological disorders. — PubMed · 2005 · Journal Article
- A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries — ClinicalTrials.gov · 2005 · Interventional · Completed
- Step forwards for spinal-cord repair. — PubMed · 2004 · News
- Safety and Efficacy of Cethrin® in Adult Subjects With Acute Cervical Spinal Cord Injury — ClinicalTrials.gov · Interventional · Withdrawn
Indexed as work in animals
- Netrin-1 derived from BMSC-exosomes promotes axonal regeneration and functional recovery after spinal cord injury via inhibition of the RhoA/ROCK pathway. — PubMed · 2026 · Journal Article
- Improving neuronal recovery in spinal cord injury with NEP1-40-modified neural stem cells through RhoA/ROCK signaling pathway modulation. — PubMed · 2025 · Journal Article
- LDH nanoparticles-doped cellulose nanofiber scaffolds with aligned microchannels direct high-efficiency neural regeneration and organized neural circuit remodeling through RhoA/Rock/Myosin II pathway. — PubMed · 2025 · Journal Article
- The potential role of RhoA/ROCK-inhibition on locomotor recovery after spinal cord injury: a systematic review of in-vivo studies. — PubMed · 2025 · Journal Article
- Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Schwann Cell-Derived Exosomes Induced Axon Growth after Spinal Cord Injury by Decreasing PTP-σ Activation on CSPGs via the Rho/ROCK Pathway. — PubMed · 2024 · Journal Article
- PD-1 deficiency aggravates spinal cord injury by regulating the reprogramming of NG2 glia and activating the NgR/RhoA/ROCK signaling pathway. — PubMed · 2024 · Journal Article
- Chondroitin 6-sulfate-binding peptides improve recovery in spinal cord-injured mice. — PubMed · 2021 · Journal Article
- Ibuprofen does not inhibit RhoA-mediated growth cone collapse of embryonic chicken retinal axons by LPA. — PubMed · 2021 · Journal Article
- A rationally designed self-immolative linker enhances the synergism between a polymer-rock inhibitor conjugate and neural progenitor cells in the treatment of spinal cord injury. — PubMed · 2021 · Journal Article
- AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo. — PubMed · 2021 · Journal Article
- Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury. — PubMed · 2020 · Journal Article
- miR-30b Promotes spinal cord sensory function recovery via the Sema3A/NRP-1/PlexinA1/RhoA/ROCK Pathway. — PubMed · 2020 · Journal Article
- Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors. — PubMed · 2019 · Journal Article
- P2Y12 regulates microglia activation and excitatory synaptic transmission in spinal lamina II neurons during neuropathic pain in rodents. — PubMed · 2019 · Journal Article
- [Electroacupuncture Improves Limb Locomotor Function Possibly by Suppressing Rho-ROCK Ⅱ Pathway Related Factors in Anterior Horns of Spinal Cord in Rats with Acute Spinal Cord Injury]. — PubMed · 2018 · Journal Article
- β-Elemene Enhances GAP-43 Expression and Neurite Outgrowth by Inhibiting RhoA Kinase Activation in Rats with Spinal Cord Injury. — PubMed · 2018 · Journal Article
- RhoA/Rho Kinase Mediates Neuronal Death Through Regulating cPLA(2) Activation. — PubMed · 2017 · Journal Article
- Combined application of Rho-ROCKII and GSK-3β inhibitors exerts an improved protective effect on axonal regeneration in rats with spinal cord injury. — PubMed · 2016 · Journal Article
- Behavioural effects of basal ganglia rho-kinase inhibition in the unilateral 6-hydroxydopamine rat model of Parkinson's disease. — PubMed · 2016 · Journal Article
- Lentivirus-mediated PGC-1α overexpression protects against traumatic spinal cord injury in rats. — PubMed · 2016 · Journal Article
- A novel Nogo-66 receptor antagonist peptide promotes neurite regeneration in vitro. — PubMed · 2016 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 4 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1341389 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 102 · this programme has 102 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("Rho inhibitor" OR "ROCK inhibitor" OR "Cethrin") - Crossref
spinal cord injury Rho inhibitor ROCK inhibitor - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("rho-Associated Kinases"[MeSH Terms] OR "Rho inhibitor"[Title/Abstract] OR "ROCK inhibitor"[Title/Abstract] OR "Cethrin"[Title/Abstract])