A subject this map covers
Viral vector delivery
Part of: Gene therapy
What belongs here
Gene delivery by viral vector to the cord or to the neurons that reach it.
What does not belong here, however close it looks
Non-viral delivery — nanoparticles, electroporation — has its own concepts.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 92 records · 1995–2026
- Indexed as work in animals: 246 records · 1998–2026
- Indexed as laboratory work: 13 records · 1997–2021
- The source has not said who or what was studied: 68 records · 1996–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
419 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Adeno-associated virus-mediated human acidic fibroblast growth factor expression promotes functional recovery of spinal cord-contused rats. — PubMed · 2011 · Journal Article
- Branched oligomerization of cell-permeable peptides markedly enhances the transduction efficiency of adenovirus into mesenchymal stem cells. — PubMed · 2010 · Journal Article
- Transplanted neural progenitor cells expressing mutant NT3 promote myelination and partial hindlimb recovery in the chronic phase after spinal cord injury. — PubMed · 2010 · Journal Article
- BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. — PubMed · 2009 · Journal Article
- Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury. — PubMed · 2009 · Journal Article
- Adeno-associated virus-mediated gene delivery approaches for the treatment of CNS disorders. — PubMed · 2008 · Journal Article
- Targeted activation of astrocytes: a potential neuroprotective strategy. — PubMed · 2008 · Journal Article
- The neuroscientist's melting pot: immunology, cell transplantation and other delivery systems, and enlightenment of disease etiology and treatment. — PubMed · 2008 · Journal Article
- Target muscles for retrograde gene delivery to specific spinal cord segments. — PubMed · 2008 · Journal Article
- Gene transfer to the spinal cord neural scar with lentiviral vectors: predominant transgene expression in astrocytes but not in meningeal cells. — PubMed · 2007 · Journal Article
- [Construction of eukaryotic expression vector for human glial derived neurotrophic factor and its expression in spinal cord tissue of SD rat]. — PubMed · 2007 · English Abstract
- The 'current state of play' in transplantation and restoration research of the CNS. — PubMed · 2007 · Journal Article
- The pivotal role of RhoA GTPase in the molecular signaling of axon growth inhibition after CNS injury and targeted therapeutic strategies. — PubMed · 2007 · Journal Article
- Combination of adenoviral vector-mediated neurotrophin-3 gene transfer and retinoic acid promotes adult bone marrow cells to differentiate into neuronal phenotypes. — PubMed · 2006 · Journal Article
- Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. — PubMed · 2006 · Comparative Study
- Gene delivery to the spinal cord: comparison between lentiviral, adenoviral, and retroviral vector delivery systems. — PubMed · 2006 · Comparative Study
- Direct gene therapy for repair of the spinal cord. — PubMed · 2006 · Journal Article
- [Herpes vector-mediated gene therapy]. — PubMed · 2006 · Journal Article
- The experimental study of genetic engineering human neural stem cells mediated by lentivirus to express multigene. — PubMed · 2006 · Journal Article
- Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications. — PubMed · 2006 · Journal Article
- Development and application of replication-incompetent HSV-1-based vectors. — PubMed · 2005 · Journal Article
- Herpes vector-mediated gene transfer in treatment of diseases of the nervous system. — PubMed · 2004 · Journal Article
- Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. — PubMed · 2004 · Journal Article
- Gene transfer of glial cell line-derived neurotrophic factor promotes functional recovery following spinal cord contusion. — PubMed · 2003 · Journal Article
- Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. — PubMed · 2003 · Journal Article
- Construction of recombinant adenoviral vector overexpressing human HIF-1alpha gene. — PubMed · 2003 · Journal Article
- Optimal treatment timing to attenuate neuronal apoptosis via Bcl-2 gene transfer in vitro and in vivo. — PubMed · 2002 · Comparative Study
- Gene therapy for spinal applications. — PubMed · 2002 · Journal Article
- Gene therapy and spinal disorders. — PubMed · 2001 · Journal Article
- Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor. — PubMed · 2000 · Journal Article
- Preparation of brain-derived neurotrophic factor- and neurotrophin-3-secreting Schwann cells by infection with a retroviral vector. — PubMed · 1998 · Journal Article
- Ex vivo gene therapy for Alzheimer's disease and spinal cord injury. — PubMed · 1995 · Journal Article
Indexed as work in animals
- Every-Other-Day Fasting Prehabilitation Attenuates Secondary Injury Following Spinal Cord Injury and Is Associated with Stage-Dependent SREBP1-Related Metabolic-Immune Remodeling. — PubMed · 2026 · Journal Article
- Knockdown of DLGAP5 inhibits microglia activation in spinal cord injury rats through limiting NF-κB activation. — PubMed · 2026 · Journal Article
- TERT Promotes Reactive Astrocytes Proliferation and Differentiation Through the Wnt/β-Catenin Pathway and Improves Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Transneuronal cytokine delivery promotes functional recovery across spinal cord contusion severities via descending circuit plasticity. — PubMed · 2026 · Journal Article
- PLD3-mediated Mitophagy Attenuates Neuronal Ferroptosis and Promotes Functional Recovery after Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Silencing of Ifi27l2a Attenuates Inflammation After Spinal Cord Injury by Regulating Microglial Polarization via JAK2/STAT3 Signaling. — PubMed · 2026 · Journal Article
- Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats. — PubMed · 2026 · Journal Article
- Ccn1 Mediates Pyroptosis and Purine Metabolism Pattern Shifts in a High-Uric Acid Microenvironment After Spinal Cord Injury. — PubMed · 2025 · Journal Article
- AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury. — PubMed · 2025 · Journal Article
- Fetal rat neural progenitor cell transplantation after spinal cord injury improves motor recovery following optogenetic stimulation. — PubMed · 2025 · Journal Article
- Chemogenetic activation of the diaphragm after spinal cord injury in rats. — PubMed · 2025 · Journal Article
- UCP2 attenuates neural apoptosis and inflammation in spinal cord injury by inducing the acetylation of ANXA1 and activating the PI3K/AKT pathway. — PubMed · 2025 · Journal Article
- Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury. — PubMed · 2025 · Journal Article
- Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury. — PubMed · 2025 · Journal Article
- Hyperactive delta isoform of PI3 kinase enables long-distance regeneration of adult rat corticospinal tract. — PubMed · 2025 · Journal Article
- Shh Protects the Injured Spinal Cord in Mice by Promoting the Proliferation and Inhibiting the Apoptosis of Nerve Cells via the Gli1-TGF-β1/ERK Axis. — PubMed · 2025 · Journal Article
- Heme Oxygenase-1 Overexpression Activates the IRF1/DRP1 Signaling Pathway to Promote M2-Type Polarization of Spinal Cord Microglia. — PubMed · 2024 · Journal Article
- Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury. — PubMed · 2024 · Journal Article
- TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid droplet accumulation after acute spinal cord injury. — PubMed · 2024 · Journal Article
- Astrocyte-derived lipocalin 2 promotes inflammation and scarring after spinal cord injury by activating SMAD in mice. — PubMed · 2024 · Journal Article
- Critical role of checkpoint kinase 1 in spinal cord injury-induced motor dysfunction in mice. — PubMed · 2024 · Journal Article
- Neuronal repair after spinal cord injury by in vivo astrocyte reprogramming mediated by the overexpression of NeuroD1 and Neurogenin-2. — PubMed · 2024 · Journal Article
- AAV6 mediated Gsx1 expression in neural stem progenitor cells promotes neurogenesis and restores locomotor function after contusion spinal cord injury. — PubMed · 2024 · Journal Article
- AAV-mediated VEGFA overexpression promotes angiogenesis and recovery of locomotor function following spinal cord injury via PI3K/Akt signaling. — PubMed · 2024 · Journal Article
- Knockdown of calpain1 in lumbar motoneurons reduces spasticity after spinal cord injury in adult rats. — PubMed · 2024 · Journal Article
- Myelin repair of spinal cord injury in adult mice induced by treadmill training upregulated peroxisome proliferator-activated receptor gamma coactivator 1 alpha. — PubMed · 2024 · Journal Article
- Microchip encapsulation and microRNA-7 overexpression of trabecular meshwork mesenchymal stem/stromal cells improve motor function after spinal cord injury. — PubMed · 2023 · Journal Article
- Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression. — PubMed · 2023 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-17 | the source found 2898038 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 393 · this programme has 393 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("adeno-associated virus" OR "AAV vector" OR "lentiviral vector") - Crossref
spinal cord injury adeno-associated virus AAV vector - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Dependovirus"[MeSH Terms] OR "Genetic Vectors"[MeSH Terms] OR "adeno-associated virus"[Title/Abstract] OR "AAV vector"[Title/Abstract] OR "lentiviral vector"[Title/Abstract])