A subject this map covers
Viral vector delivery
Part of: Gene therapy
What belongs here
Gene delivery by viral vector to the cord or to the neurons that reach it.
What does not belong here, however close it looks
Non-viral delivery — nanoparticles, electroporation — has its own concepts.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 92 records · 1995–2026
- Indexed as work in animals: 246 records · 1998–2026
- Indexed as laboratory work: 13 records · 1997–2021
- The source has not said who or what was studied: 68 records · 1996–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
419 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Schwann cell transplantation improves reticulospinal axon growth and forelimb strength after severe cervical spinal cord contusion. — PubMed · 2007 · Journal Article
- Transplantation of fibroblasts that overexpress matrix metalloproteinase-3 into the site of spinal cord injury in rats. — PubMed · 2006 · Journal Article
- Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. — PubMed · 2006 · Journal Article
- Lentiviral vector expressing retinoic acid receptor beta2 promotes recovery of function after corticospinal tract injury in the adult rat spinal cord. — PubMed · 2006 · Journal Article
- Expression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cord. — PubMed · 2006 · Comparative Study
- Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compression. — PubMed · 2006 · Journal Article
- Genetic engineering neural stem cell modified by lentivirus for repair of spinal cord injury in rats. — PubMed · 2006 · Journal Article
- Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury. — PubMed · 2006 · Journal Article
- Genetic manipulation of intraspinal plasticity after spinal cord injury alters the severity of autonomic dysreflexia. — PubMed · 2006 · Journal Article
- Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. — PubMed · 2006 · Comparative Study
- Integration of genetically modified adult astrocytes into the lesioned rat spinal cord. — PubMed · 2006 · Journal Article
- In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury. — PubMed · 2005 · Journal Article
- Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system. — PubMed · 2005 · Journal Article
- Targeted retrograde gene delivery into the injured cervical spinal cord using recombinant adenovirus vector. — PubMed · 2005 · Comparative Study
- Enhanced functional recovery from spinal cord injury following intrathecal or intramuscular administration of poliovirus replicons encoding IL-10. — PubMed · 2005 · Comparative Study
- Intrathecal gene delivery of glial cell line-derived neurotrophic factor ameliorated paraplegia in rats after spinal ischemia. — PubMed · 2005 · Comparative Study
- Lentiviral vector-mediated transduction of neural progenitor cells before implantation into injured spinal cord and brain to detect their migration, deliver neurotrophic factors and repair tissue. — PubMed · 2005 · Comparative Study
- Survival, integration, and axon growth support of glia transplanted into the chronically contused spinal cord. — PubMed · 2005 · Journal Article
- Potent pro-inflammatory actions of leukemia inhibitory factor in the spinal cord of the adult mouse. — PubMed · 2004 · Journal Article
- Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain. — PubMed · 2004 · Journal Article
- Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury. — PubMed · 2004 · Journal Article
- Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord. — PubMed · 2004 · Journal Article
- Recombinant AAV-mediated gene delivery to the central nervous system. — PubMed · 2004 · Journal Article
- Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury. — PubMed · 2003 · Journal Article
- A herpesvirus vector can transduce axotomized brain neurons. — PubMed · 2003 · Journal Article
- Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord. — PubMed · 2003 · Journal Article
- Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function. — PubMed · 2003 · Journal Article
- Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system. — PubMed · 2002 · Journal Article
- Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. — PubMed · 2002 · Journal Article
- Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord. — PubMed · 2002 · Journal Article
- Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy. — PubMed · 2001 · Journal Article
- Adenovirus-mediated glial cell line-derived neurotrophic factor gene delivery reduces motor neuron injury after transient spinal cord ischemia in rabbits. — PubMed · 2000 · Journal Article
- Partial functional recovery of paraplegic rat by adenovirus-mediated gene delivery of constitutively active MEK1. — PubMed · 2000 · Journal Article
- Herpes simplex viral and amplicon vector-mediated gene transfer into glia and neurons in organotypic spinal cord and dorsal root ganglion cultures. — PubMed · 2000 · Journal Article
- A multi-mutant herpes simplex virus vector has minimal cytotoxic effects on the distribution of filamentous actin, alpha-actinin 2 and a glutamate receptor in differentiated PC12 cells. — PubMed · 2000 · Journal Article
- Adenoviral gene transfer into the normal and injured spinal cord: enhanced transgene stability by combined administration of temperature-sensitive virus and transient immune blockade. — PubMed · 1998 · Journal Article
- NT-3 delivered by an adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats. — PubMed · 1998 · Journal Article
- Intraspinal grafting of fibroblasts genetically modified by recombinant adenoviruses. — PubMed · 1998 · Journal Article
Indexed as laboratory work
- Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice. — PubMed · 2021 · Journal Article
- Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling. — PubMed · 2017 · Journal Article
- CCL2 Mediates Neuron-Macrophage Interactions to Drive Proregenerative Macrophage Activation Following Preconditioning Injury. — PubMed · 2015 · Journal Article
- PERK pathway is involved in oxygen-glucose-serum deprivation-induced NF-kB activation via ROS generation in spinal cord astrocytes. — PubMed · 2015 · Journal Article
- Effects of brain‑derived neurotrophic factor and neurotrophin‑3 on the neuronal differentiation of rat adipose‑derived stem cells. — PubMed · 2015 · Journal Article
- Establishment and expression of recombinant human glial cell line-derived neurotrophic factor and TNF α receptor in human neural stem cells. — PubMed · 2012 · Evaluation Study
- Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. — PubMed · 2010 · Journal Article
- Co-transplantation of bFGF-expressing amniotic epithelial cells and neural stem cells promotes functional recovery in spinal cord-injured rats. — PubMed · 2008 · Journal Article
- Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury. — PubMed · 2007 · Journal Article
- NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration. — PubMed · 2005 · Journal Article
- Olfactory ensheathing cells genetically modified to secrete GDNF to promote spinal cord repair. — PubMed · 2004 · Journal Article
- The use of adenoviral vectors and ex vivo transduced neurotransplants: towards promotion of neuroregeneration. — PubMed · 2000 · Journal Article
- Potential use of herpes simplex virus (HSV) vectors for gene therapy of neurological disorders. — PubMed · 1997 · Journal Article
The source has not said who or what was studied
- Therapeutic potential of astrocyte transdifferentiated neurons. — PubMed · 2026 · Journal Article
- NRN1 inhibits neuronal apoptosis and improves motor recovery after spinal cord injury via binding to FZD2 to activate the GSK-3β/Nrf2 pathway. — PubMed · 2026 · Journal Article
- Examining Mgat5 upregulation's protective effects and underlying mechanisms in spinal cord injury. — PubMed · 2026 · Journal Article
- The role of microglial Tim-3 in neuroinflammation and functional recovery after spinal cord injury. — PubMed · 2026 · Journal Article
- The role of gene therapy in neural injury repair. — PubMed · 2026 · Journal Article
- TRIM59 alleviates neuronal ferroptosis and promotes functional recovery after spinal cord injury by mediating ubiquitination and degradation of ANXA2. — PubMed · 2026 · Journal Article
- LXRα/SCD1-Mediated Endoplasmic Reticulum-Mitochondria Crosstalk in Inhibiting Neuronal Ferroptosis after Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Optogenetic approaches for neural tissue regeneration: A review of basic optogenetic principles and target cells for therapy. — PubMed · 2026 · Journal Article
- Selective Enrichment and Identification of Cerebrospinal Fluid-Contacting Neurons In Vitro via PKD2L1 Promoter-Driven Lentiviral System. — PubMed · 2025 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-17 | the source found 2898038 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 393 · this programme has 393 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("adeno-associated virus" OR "AAV vector" OR "lentiviral vector") - Crossref
spinal cord injury adeno-associated virus AAV vector - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Dependovirus"[MeSH Terms] OR "Genetic Vectors"[MeSH Terms] OR "adeno-associated virus"[Title/Abstract] OR "AAV vector"[Title/Abstract] OR "lentiviral vector"[Title/Abstract])