A subject this map covers
Viral vector delivery
Part of: Gene therapy
What belongs here
Gene delivery by viral vector to the cord or to the neurons that reach it.
What does not belong here, however close it looks
Non-viral delivery — nanoparticles, electroporation — has its own concepts.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 92 records · 1995–2026
- Indexed as work in animals: 246 records · 1998–2026
- Indexed as laboratory work: 13 records · 1997–2021
- The source has not said who or what was studied: 68 records · 1996–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
419 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Synergistic effects of BDNF and rehabilitative training on recovery after cervical spinal cord injury. — PubMed · 2013 · Journal Article
- The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127. — PubMed · 2013 · Journal Article
- Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site. — PubMed · 2013 · Journal Article
- The retrograde delivery of adenovirus vector carrying the gene for brain-derived neurotrophic factor protects neurons and oligodendrocytes from apoptosis in the chronically compressed spinal cord of twy/twy mice. — PubMed · 2012 · Journal Article
- Chondroitinase ABC promotes plasticity of spinal reflexes following peripheral nerve injury. — PubMed · 2012 · Journal Article
- Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord. — PubMed · 2012 · Journal Article
- Herpes simplex virus vector-mediated expression of interleukin-10 reduces below-level central neuropathic pain after spinal cord injury. — PubMed · 2012 · Comparative Study
- Effects of retrograde gene transfer of brain-derived neurotrophic factor in the rostral spinal cord of a compression model in rat. — PubMed · 2012 · Journal Article
- Tissue repair driven by two different mechanisms of growth factor plasmids VEGF and NGF in mice auricular cartilage: regeneration mediated by administering growth factor plasmids. — PubMed · 2012 · Journal Article
- Motor axonal regeneration after partial and complete spinal cord transection. — PubMed · 2012 · Journal Article
- [Neuroprotective effects of recombinant adeno-associated virus expressing vascular endothelial growth factor on rat traumatic spinal cord injury and its mechanism]. — PubMed · 2012 · English Abstract
- The protective effects of the lentivirus-mediated neuroglobin gene transfer on spinal cord injury in rabbits. — PubMed · 2012 · Journal Article
- Lentiviral vector mediates exogenous gene expression in adult rat DRG following peripheral nerve remote delivery. — PubMed · 2012 · Journal Article
- BDNF and NT-3 expression by using glucocorticoid-induced bicistronic expression vector pGC-BDNF-IRES-NT3 protects apoptotic cells in a cellular injury model. — PubMed · 2012 · Journal Article
- [Experiment study on the treatment of SCI based on HSV carried BDNF transgene technique]. — PubMed · 2012 · English Abstract
- Lentivirus-siNgR199 promotes axonal regeneration and functional recovery in rats. — PubMed · 2012 · Journal Article
- Activation of the unfolded protein response enhances motor recovery after spinal cord injury. — PubMed · 2012 · Journal Article
- Neurotrophin-3 gene modified mesenchymal stem cells promote remyelination and functional recovery in the demyelinated spinal cord of rats. — PubMed · 2012 · Comparative Study
- Comparison of AAV2 and AAV5 in gene transfer in the injured spinal cord of mice. — PubMed · 2011 · Comparative Study
- Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo. — PubMed · 2011 · Journal Article
- Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons. — PubMed · 2011 · Journal Article
- Controlled nonviral gene delivery and expression using stable neural stem cell line transfected with a hypoxia-inducible gene expression system. — PubMed · 2010 · Journal Article
- Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord. — PubMed · 2010 · Journal Article
- Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury. — PubMed · 2010 · Journal Article
- [Lentiviral vector-mediated RNA interfere gene Nogo receptor to repair spinal cord injury]. — PubMed · 2010 · Journal Article
- The extracellular matrix glycoprotein tenascin-C is beneficial for spinal cord regeneration. — PubMed · 2010 · Journal Article
- Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. — PubMed · 2010 · Journal Article
- Promoting directional axon growth from neural progenitors grafted into the injured spinal cord. — PubMed · 2010 · Journal Article
- Targeted retrograde gene delivery of brain-derived neurotrophic factor suppresses apoptosis of neurons and oligodendroglia after spinal cord injury in rats. — PubMed · 2010 · Journal Article
- Transplantation of ciliary neurotrophic factor-expressing adult oligodendrocyte precursor cells promotes remyelination and functional recovery after spinal cord injury. — PubMed · 2010 · Journal Article
- An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury. — PubMed · 2010 · Journal Article
- [Construction and screening of neurite outgrowth inhibitory 66 eukaryotic expression vectors]. — PubMed · 2010 · Journal Article
- Targeting a dominant negative rho kinase to neurons promotes axonal outgrowth and partial functional recovery after rat rubrospinal tract lesion. — PubMed · 2009 · Journal Article
- [The repair of acute spinal cord injury in rats by olfactory ensheathing cells graft modified by glia cell line-derived neurotrophic factor gene in combination with the injection of monoclonal antibody IN-1]. — PubMed · 2009 · English Abstract
- Downregulation of thymosin beta4 in neural progenitor grafts promotes spinal cord regeneration. — PubMed · 2009 · Journal Article
- IL-10 promotes neuronal survival following spinal cord injury. — PubMed · 2009 · Journal Article
- Neurotrophic factor-expressing mesenchymal stem cells survive transplantation into the contused spinal cord without differentiating into neural cells. — PubMed · 2009 · Journal Article
- Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. — PubMed · 2009 · Journal Article
- Reconnecting injured nerves. — PubMed · 2009 · Comment
- HSV-mediated transfer of artemin overcomes myelin inhibition to improve outcome after spinal cord injury. — PubMed · 2009 · Journal Article
- Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. — PubMed · 2009 · Journal Article
- Combination of microsurgery and gene therapy for spinal dorsal root injury repair. — PubMed · 2009 · Journal Article
- Herpes simplex virus vector-mediated gene delivery of glutamic acid decarboxylase reduces detrusor overactivity in spinal cord-injured rats. — PubMed · 2009 · Evaluation Study
- Selective gene transfer into neurons via Na,K-ATPase beta1. Targeting gene transfer with monoclonal antibody and adenovirus vector. — PubMed · 2008 · Journal Article
- No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse. — PubMed · 2008 · Journal Article
- Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury. — PubMed · 2008 · Journal Article
- Immune activation is required for NT-3-induced axonal plasticity in chronic spinal cord injury. — PubMed · 2008 · Journal Article
- Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. — PubMed · 2008 · Journal Article
- Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord. — PubMed · 2007 · Journal Article
- Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury. — PubMed · 2007 · Journal Article
- [Impact of different drugs and different volumes injected intraspinally on the nerve function: experiment with rats]. — PubMed · 2007 · English Abstract
- Gene transfer to interfere with TNFalpha signaling in neuropathic pain. — PubMed · 2007 · Journal Article
- Hypoxia-inducible expression of vascular endothelial growth factor for the treatment of spinal cord injury in a rat model. — PubMed · 2007 · Journal Article
- Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery. — PubMed · 2007 · Journal Article
- Brain-derived neurotrophic factor gene transfer with adeno-associated viral and lentiviral vectors prevents rubrospinal neuronal atrophy and stimulates regeneration-associated gene expression after acute cervical spinal cord injury. — PubMed · 2007 · Journal Article
- Induced expression of polysialic acid in the spinal cord promotes regeneration of sensory axons. — PubMed · 2007 · Journal Article
- Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury. — PubMed · 2007 · Journal Article
- A hypoxia-inducible gene expression system using erythropoietin 3' untranslated region for the gene therapy of rat spinal cord injury. — PubMed · 2007 · Journal Article
- Combined treatment of neurotrophin-3 gene and neural stem cells is propitious to functional recovery after spinal cord injury. — PubMed · 2007 · Journal Article
- Lentiviral vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune "stealth" transgene. — PubMed · 2007 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-17 | the source found 2898038 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 393 · this programme has 393 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("adeno-associated virus" OR "AAV vector" OR "lentiviral vector") - Crossref
spinal cord injury adeno-associated virus AAV vector - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Dependovirus"[MeSH Terms] OR "Genetic Vectors"[MeSH Terms] OR "adeno-associated virus"[Title/Abstract] OR "AAV vector"[Title/Abstract] OR "lentiviral vector"[Title/Abstract])