A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Microfiber drug/gene delivery platform for study of myelination. — PubMed · 2018 · Journal Article
- Long noncoding RNA MALAT1 contributes to inflammatory response of microglia following spinal cord injury via the modulation of a miR-199b/IKKβ/NF-κB signaling pathway. — PubMed · 2018 · Journal Article
- MiR-25 protects PC-12 cells from H(2)O(2) mediated oxidative damage via WNT/β-catenin pathway. — PubMed · 2018 · Journal Article
- Time-dependent, bidirectional, anti- and pro-spinal hyper-reflexia and muscle spasticity effect after chronic spinal glycine transporter 2 (GlyT2) oligonucleotide-induced downregulation. — PubMed · 2018 · Journal Article
- microRNA-21 regulates astrocytic reaction post-acute phase of spinal cord injury through modulating TGF-β signaling. — PubMed · 2018 · Journal Article
- miR-411 suppresses acute spinal cord injury via downregulation of Fas ligand in rats. — PubMed · 2018 · Journal Article
- Knockdown of Ski decreased the reactive astrocytes proliferation in vitro induced by oxygen-glucose deprivation/reoxygenation. — PubMed · 2018 · Journal Article
- MicroRNA-409 promotes recovery of spinal cord injury by regulating ZNF366. — PubMed · 2018 · Journal Article
- Ecto-5'-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice. — PubMed · 2018 · Journal Article
- The Role of Smurf1 in Neuronal Necroptosis after Lipopolysaccharide-Induced Neuroinflammation. — PubMed · 2018 · Journal Article
- Phrenic motor neuron adenosine 2A receptors elicit phrenic motor facilitation. — PubMed · 2018 · Journal Article
- Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. — PubMed · 2018 · Journal Article
- Lentiviral vector delivery of short hairpin RNA to NgR1 promotes nerve regeneration and locomotor recovery in injured rat spinal cord. — PubMed · 2018 · Journal Article
- MiR-137 attenuates spinal cord injury by modulating NEUROD4 through reducing inflammation and oxidative stress. — PubMed · 2018 · Journal Article
- MicroRNA-125b promotes the regeneration and repair of spinal cord injury through regulation of JAK/STAT pathway. — PubMed · 2018 · Journal Article
- MicroRNA-21-5p mediates TGF-β-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury. — PubMed · 2018 · Journal Article
- Effects of MicroRNA-494 on Astrocyte Proliferation and Synaptic Remodeling in the Spinal Cord of a Rat Model of Chronic Compressive Spinal Cord Injury by Regulating the Nogo/Ngr Signaling Pathway. — PubMed · 2018 · Journal Article The source marks this record as retracted.
- Knockdown of lncRNA BDNF-AS suppresses neuronal cell apoptosis via downregulating miR-130b-5p target gene PRDM5 in acute spinal cord injury. — PubMed · 2018 · Journal Article
- Lentivirus-mediated silencing of the CTGF gene suppresses the formation of glial scar tissue in a rat model of spinal cord injury. — PubMed · 2018 · Journal Article
- miR-136-5p Regulates the Inflammatory Response by Targeting the IKKβ/NF-κB/A20 Pathway After Spinal Cord Injury. — PubMed · 2018 · Journal Article
- MiR-30a-5p ameliorates spinal cord injury-induced inflammatory responses and oxidative stress by targeting Neurod 1 through MAPK/ERK signalling. — PubMed · 2018 · Journal Article
- miRNA-138 regulates MLK3/JNK/MAPK pathway to protect BV-2 cells from H2O2-induced apoptosis. — PubMed · 2018 · Journal Article
- miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4. — PubMed · 2018 · Journal Article
- Spatiotemporal expression of FOXA1 correlates with reactive gliosis after spinal cord injury. — PubMed · 2017 · Journal Article
- Suppression of miR-127 protects PC-12 cells from LPS-induced inflammatory injury by downregulation of PDCD4. — PubMed · 2017 · Journal Article
- miR-181d-5p promotes neurite outgrowth in PC12 Cells via PI3K/Akt pathway. — PubMed · 2017 · Journal Article
- TWEAK-Fn14 Influences Neurogenesis Status via Modulating NF-κB in Mice with Spinal Cord Injury. — PubMed · 2017 · Journal Article The source marks this record as retracted.
- Expression of Ski and its role in astrocyte proliferation and migration. — PubMed · 2017 · Journal Article
- MiR-136 controls neurocytes apoptosis by regulating Tissue Inhibitor of Metalloproteinases-3 in spinal cord ischemic injury. — PubMed · 2017 · Journal Article
- Up-regulation of TRAF2 Suppresses Neuronal Apoptosis after Rat Spinal Cord Injury. — PubMed · 2017 · Journal Article
- The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases. — PubMed · 2017 · Journal Article
- Bioinformatics analyses of pathways and gene predictions in IL-1α and IL-1β knockout mice with spinal cord injury. — PubMed · 2017 · Journal Article
- MicroRNA‑21 promotes neurite outgrowth by regulating PDCD4 in a rat model of spinal cord injury. — PubMed · 2017 · Journal Article
- Α-synuclein induces microglial cell migration through stimulating HIF-1α accumulation. — PubMed · 2017 · Journal Article
- lncRNA-Map2k4 sequesters miR-199a to promote FGF1 expression and spinal cord neuron growth. — PubMed · 2017 · Journal Article
- A causal relationship between the neurotherapeutic effects of miR182/7a and decreased expression of PRDM5. — PubMed · 2017 · Journal Article
- Knockdown of ANRIL aggravates H(2)O(2)-induced injury in PC-12 cells by targeting microRNA-125a. — PubMed · 2017 · Journal Article The source marks this record as retracted.
- MicroRNA-494 improves functional recovery and inhibits apoptosis by modulating PTEN/AKT/mTOR pathway in rats after spinal cord injury. — PubMed · 2017 · Journal Article
- Effects of Alpha-Synuclein on Primary Spinal Cord Neurons Associated with Apoptosis and CNTF Expression. — PubMed · 2017 · Journal Article
- Lentivirus-mediated microRNA-124 gene-modified bone marrow mesenchymal stem cell transplantation promotes the repair of spinal cord injury in rats. — PubMed · 2017 · Journal Article
- Serum MicroRNAs Reflect Injury Severity in a Large Animal Model of Thoracic Spinal Cord Injury. — PubMed · 2017 · Journal Article
- Effects of liposome-based local suppression of nerve growth factor in the bladder on autonomic dysreflexia during urinary bladder distention in rats with spinal cord injury. — PubMed · 2017 · Journal Article
- Electro-acupuncture-modulated miR-214 prevents neuronal apoptosis by targeting Bax and inhibits sodium channel Nav1.3 expression in rats after spinal cord injury. — PubMed · 2017 · Journal Article
- Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury. — PubMed · 2017 · Journal Article
- RETRACTED: Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury. — PubMed · 2017 · Journal Article The source marks this record as retracted.
- RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model. — PubMed · 2017 · Journal Article
- Salvianolic acid A ameliorates the integrity of blood-spinal cord barrier via miR-101/Cul3/Nrf2/HO-1 signaling pathway. — PubMed · 2017 · Journal Article
- BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury. — PubMed · 2017 · Journal Article The source marks this record as retracted.
- The Expression of IGFBP6 after Spinal Cord Injury: Implications for Neuronal Apoptosis. — PubMed · 2017 · Journal Article
- The expression of chemorepulsive guidance receptors and the regenerative abilities of spinal-projecting neurons after spinal cord injury. — PubMed · 2017 · Journal Article
- Down-Regulation of miRNA-128 Contributes to Neuropathic Pain Following Spinal Cord Injury via Activation of P38. — PubMed · 2017 · Journal Article
- Curcumin inhibits glial scar formation by suppressing astrocyte-induced inflammation and fibrosis in vitro and in vivo. — PubMed · 2017 · Journal Article
- Synchrotron radiation micro-CT as a novel tool to evaluate the effect of agomir-210 in a rat spinal cord injury model. — PubMed · 2017 · Journal Article
- MiR-17 targets PTEN and facilitates glial scar formation after spinal cord injuries via the PI3K/Akt/mTOR pathway. — PubMed · 2017 · Journal Article
- Molecular Mechanism of MiR-136-5p Targeting NF-κB/A20 in the IL-17-Mediated Inflammatory Response after Spinal Cord Injury. — PubMed · 2017 · Journal Article
- NFAT5 protects astrocytes against oxygen-glucose-serum deprivation/restoration damage via the SIRT1/Nrf2 pathway. — PubMed · 2017 · Journal Article
- Critical role of regulator of calcineurin 1 in spinal cord injury. — PubMed · 2016 · Journal Article
- Increased plasma VEGF levels following ischemic preconditioning are associated with downregulation of miRNA-762 and miR-3072-5p. — PubMed · 2016 · Journal Article
- Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells. — PubMed · 2016 · Journal Article
- Naringenin inhibits spinal cord injury-induced activation of neutrophils through miR-223. — PubMed · 2016 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])