A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Changes in the Expression of miR-34a and its Target Genes Following Spinal Cord Injury In Rats. — PubMed · 2016 · Journal Article
- MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection. — PubMed · 2016 · Journal Article
- Combination of grafted Schwann cells and lentiviral-mediated prevention of glial scar formation improve recovery of spinal cord injured rats. — PubMed · 2016 · Journal Article
- Nanoparticle-Delivered IRF5 siRNA Facilitates M1 to M2 Transition, Reduces Demyelination and Neurofilament Loss, and Promotes Functional Recovery After Spinal Cord Injury in Mice. — PubMed · 2016 · Journal Article
- Protective effects of BMP-7 against tumor necrosis factor α-induced oligodendrocyte apoptosis. — PubMed · 2016 · Journal Article
- Temporal and Spatial Expression of LGR5 After Acute Spinal Cord Injury in Adult Rats. — PubMed · 2016 · Journal Article
- Tetramethylpyrazine enhances functional recovery after contusion spinal cord injury by modulation of MicroRNA-21, FasL, PDCD4 and PTEN expression. — PubMed · 2016 · Journal Article
- Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats. — PubMed · 2016 · Journal Article
- Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke. — PubMed · 2016 · Journal Article
- PCBP2 Modulates Neural Apoptosis and Astrocyte Proliferation After Spinal Cord Injury. — PubMed · 2016 · Journal Article
- miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair. — PubMed · 2016 · Journal Article
- Fatty Acid Binding Protein 5 Modulates Docosahexaenoic Acid-Induced Recovery in Rats Undergoing Spinal Cord Injury. — PubMed · 2016 · Journal Article
- Knockdown of Nogo gene by short hairpin RNA interference promotes functional recovery of spinal cord injury in a rat model. — PubMed · 2016 · Journal Article
- Cationic, amphiphilic copolymer micelles as nucleic acid carriers for enhanced transfection in rat spinal cord. — PubMed · 2016 · Journal Article
- Knockdown of α-synuclein in cerebral cortex improves neural behavior associated with apoptotic inhibition and neurotrophin expression in spinal cord transected rats. — PubMed · 2016 · Journal Article
- MiR-93 Targeting EphA4 Promotes Neurite Outgrowth from Spinal Cord Neurons. — PubMed · 2016 · Journal Article
- miR-434-3p and DNA hypomethylation co-regulate eIF5A1 to increase AChRs and to improve plasticity in SCT rat skeletal muscle. — PubMed · 2016 · Journal Article
- Lingo-1 shRNA and Notch signaling inhibitor DAPT promote differentiation of neural stem/progenitor cells into neurons. — PubMed · 2016 · Journal Article
- MicroRNA-9 controls apoptosis of neurons by targeting monocyte chemotactic protein-induced protein 1 expression in rat acute spinal cord injury model. — PubMed · 2016 · Journal Article
- The Angiogenic Effect of microRNA-21 Targeting TIMP3 through the Regulation of MMP2 and MMP9. — PubMed · 2016 · Journal Article
- Bioinformatics Analysis of microRNA Time-Course Expression in Brown Rat (Rattus norvegicus): Spinal Cord Injury Self-Repair. — PubMed · 2016 · Journal Article
- Decreased miR-195 Expression Protects Rats from Spinal Cord Injury Primarily by Targeting HIF-1α. — PubMed · 2016 · Journal Article
- MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression. — PubMed · 2016 · Journal Article
- MicroRNA-9 regulates osteoblast differentiation and angiogenesis via the AMPK signaling pathway. — PubMed · 2016 · Journal Article
- Neuroprotective effect of allicin in a rat model of acute spinal cord injury. — PubMed · 2015 · Journal Article
- CISD2 serves a novel role as a suppressor of nitric oxide signalling and curcumin increases CISD2 expression in spinal cord injuries. — PubMed · 2015 · Journal Article
- Neuroprotective effect of functionalized multi-walled carbon nanotubes on spinal cord injury in rats. — PubMed · 2015 · Journal Article
- Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration. — PubMed · 2015 · Journal Article
- Fluorescent Phosphorus Dendrimer as a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury. — PubMed · 2015 · Journal Article
- MicroRNA-21 regulates cell proliferation and apoptosis in H₂O₂-stimulated rat spinal cord neurons. — PubMed · 2015 · Journal Article
- Down regulation of lncSCIR1 after spinal cord contusion injury in rat. — PubMed · 2015 · Journal Article
- miR-381 Regulates Neural Stem Cell Proliferation and Differentiation via Regulating Hes1 Expression. — PubMed · 2015 · Journal Article The source marks this record as retracted.
- MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death. — PubMed · 2015 · Journal Article
- A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury. — PubMed · 2015 · Journal Article
- Antisense Morpholino Oligonucleotides Reduce Neurofilament Synthesis and Inhibit Axon Regeneration in Lamprey Reticulospinal Neurons. — PubMed · 2015 · Journal Article
- Identification of microRNAome in rat bladder reveals miR-1949 as a potential inducer of bladder cancer following spinal cord injury. — PubMed · 2015 · Journal Article
- Regulation of gene expression in rats with spinal cord injury based on microarray data. — PubMed · 2015 · Journal Article
- Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. — PubMed · 2015 · Journal Article
- AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury. — PubMed · 2015 · Journal Article
- Spatiotemporal Expression of EAPP Modulates Neuronal Apoptosis and Reactive Astrogliosis After Spinal Cord Injury. — PubMed · 2015 · Journal Article
- Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury. — PubMed · 2015 · Journal Article
- miR-126 promotes angiogenesis and attenuates inflammation after contusion spinal cord injury in rats. — PubMed · 2015 · Journal Article
- Administration of antagomir-223 inhibits apoptosis, promotes angiogenesis and functional recovery in rats with spinal cord injury. — PubMed · 2015 · Journal Article
- MicroRNA-155 Deficiency Suppresses Th17 Cell Differentiation and Improves Locomotor Recovery after Spinal Cord Injury. — PubMed · 2015 · Journal Article
- shRNA against PTEN promotes neurite outgrowth of cortical neurons and functional recovery in spinal cord contusion rats. — PubMed · 2015 · Journal Article
- MiR-124 promotes bone marrow mesenchymal stem cells differentiation into neurogenic cells for accelerating recovery in the spinal cord injury. — PubMed · 2015 · Journal Article
- Vimentin regulates neuroplasticity in transected spinal cord rats associated with micRNA138. — PubMed · 2015 · Journal Article
- Systemic administration of valproic acid stimulates overexpression of microtubule-associated protein 2 in the spinal cord injury model to promote neurite outgrowth. — PubMed · 2015 · Journal Article
- MicroRNA-145 as one negative regulator of astrogliosis. — PubMed · 2015 · Journal Article
- Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury. — PubMed · 2015 · Journal Article
- Allicin protects spinal cord neurons from glutamate-induced oxidative stress through regulating the heat shock protein 70/inducible nitric oxide synthase pathway. — PubMed · 2015 · Journal Article
- Lentiviral-mediated silencing of glial fibrillary acidic protein and vimentin promotes anatomical plasticity and functional recovery after spinal cord injury. — PubMed · 2015 · Journal Article
- Transforming growth factor β-induced expression of chondroitin sulfate proteoglycans is mediated through non-Smad signaling pathways. — PubMed · 2015 · Journal Article
- Functional requirement of dicer1 and miR-17-5p in reactive astrocyte proliferation after spinal cord injury in the mouse. — PubMed · 2014 · Journal Article
- Expression of SGTA correlates with neuronal apoptosis and reactive gliosis after spinal cord injury. — PubMed · 2014 · Journal Article
- Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury. — PubMed · 2014 · Journal Article
- The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine. — PubMed · 2014 · Journal Article
- Targeting RPTPσ with lentiviral shRNA promotes neurites outgrowth of cortical neurons and improves functional recovery in a rat spinal cord contusion model. — PubMed · 2014 · Journal Article
- Exercise preconditioning protects against spinal cord injury in rats by upregulating neuronal and astroglial heat shock protein 72. — PubMed · 2014 · Journal Article
- Spatiotemporal pattern of TRAF3 expression after rat spinal cord injury. — PubMed · 2014 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])