A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Selective inhibition of STAT1 reduces spinal cord injury in mice. — PubMed · 2014 · Journal Article
- Regulatory effects of intermittent noxious stimulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion. — PubMed · 2014 · Journal Article
- Persistent pain after spinal cord injury is maintained by primary afferent activity. — PubMed · 2014 · Journal Article
- Circulating microRNAs as biomarkers for evaluating the severity of acute spinal cord injury. — PubMed · 2014 · Journal Article
- Time-specific microRNA changes during spinal motoneuron degeneration in adult rats following unilateral brachial plexus root avulsion: ipsilateral vs. contralateral changes. — PubMed · 2014 · Journal Article
- AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury. — PubMed · 2014 · Journal Article
- Administration of microRNA-210 promotes spinal cord regeneration in mice. — PubMed · 2014 · Journal Article
- Precise control of miR-125b levels is required to create a regeneration-permissive environment after spinal cord injury: a cross-species comparison between salamander and rat. — PubMed · 2014 · Comparative Study
- GART expression in rat spinal cord after injury and its role in inflammation. — PubMed · 2014 · Journal Article
- Identifying gene expression profile of spinal cord injury in rat by bioinformatics strategy. — PubMed · 2014 · Journal Article
- Silencing ephrinB3 improves functional recovery following spinal cord injury. — PubMed · 2014 · Journal Article
- Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice. — PubMed · 2014 · Journal Article
- Expressional difference, distributions of TGF-β1 in TGF-β1 knock down transgenic mouse, and its possible roles in injured spinal cord. — PubMed · 2014 · Journal Article
- Spatial and temporal expression levels of specific microRNAs in a spinal cord injury mouse model and their relationship to the duration of compression. — PubMed · 2014 · Comparative Study
- MiR-7-1 potentiated estrogen receptor agonists for functional neuroprotection in VSC4.1 motoneurons. — PubMed · 2014 · Journal Article
- Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats. — PubMed · 2014 · Journal Article
- Upregulation of eIF-5A1 in the paralyzed muscle after spinal cord transection associates with spontaneous hindlimb locomotor recovery in rats by upregulation of the ErbB, MAPK and neurotrophin signal pathways. — PubMed · 2013 · Journal Article
- Local injection of lentivirus encoding LINGO-1-shRNA promotes functional recovery in rats with complete spinal cord transection. — PubMed · 2013 · Journal Article
- Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury. — PubMed · 2013 · Journal Article
- Role of telomerase reverse transcriptase in glial scar formation after spinal cord injury in rats. — PubMed · 2013 · Journal Article
- Transcription factor SCIRR69 involved in the activation of brain-derived neurotrophic factor gene promoter II in mechanically injured neurons. — PubMed · 2013 · Journal Article
- Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats. — PubMed · 2013 · Journal Article
- Hyaluronic acid/chitosan multilayer coatings on neuronal implants for localized delivery of siRNA nanoplexes. — PubMed · 2013 · Journal Article
- CaMKII activates ASK1 to induce apoptosis of spinal astrocytes under oxygen-glucose deprivation. — PubMed · 2013 · Journal Article
- CX3CL1/CX3CR1 regulates nerve injury-induced pain hypersensitivity through the ERK5 signaling pathway. — PubMed · 2013 · Journal Article
- Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats. — PubMed · 2013 · Journal Article
- Overexpression of melatonin membrane receptors increases calcium-binding proteins and protects VSC4.1 motoneurons from glutamate toxicity through multiple mechanisms. — PubMed · 2013 · Journal Article
- Role of neuregulin-1/ErbB signaling in stem cell therapy for spinal cord injury-induced chronic neuropathic pain. — PubMed · 2013 · Journal Article
- Transplanting p75-suppressed bone marrow stromal cells promotes functional behavior in a rat model of spinal cord injury. — PubMed · 2013 · Journal Article
- 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. — PubMed · 2012 · Journal Article
- Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord. — PubMed · 2012 · Journal Article
- miR-124 regulates neural stem cells in the treatment of spinal cord injury. — PubMed · 2012 · Journal Article
- FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction. — PubMed · 2012 · Journal Article
- Genetic study of axon regeneration with cultured adult dorsal root ganglion neurons. — PubMed · 2012 · Journal Article
- Acute molecular perturbation of inducible nitric oxide synthase with an antisense approach enhances neuronal preservation and functional recovery after contusive spinal cord injury. — PubMed · 2012 · Journal Article
- Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury. — PubMed · 2012 · Journal Article
- FOXJ2 expression in rat spinal cord after injury and its role in inflammation. — PubMed · 2012 · Journal Article
- MicroRNA 486 is a potentially novel target for the treatment of spinal cord injury. — PubMed · 2012 · Journal Article
- Lentivirus-siNgR199 promotes axonal regeneration and functional recovery in rats. — PubMed · 2012 · Journal Article
- Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury. — PubMed · 2012 · Journal Article
- MicroRNA dysregulation in the spinal cord following traumatic injury. — PubMed · 2012 · Journal Article
- Photomechanical wave-driven delivery of siRNAs targeting intermediate filament proteins promotes functional recovery after spinal cord injury in rats. — PubMed · 2012 · Journal Article
- Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury. — PubMed · 2011 · Journal Article
- MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repair. — PubMed · 2011 · Journal Article
- Delayed intrathecal delivery of RhoA siRNA to the contused spinal cord inhibits allodynia, preserves white matter, and increases serotonergic fiber growth. — PubMed · 2011 · Journal Article
- MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish. — PubMed · 2011 · Journal Article
- TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. — PubMed · 2011 · Journal Article
- Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats. — PubMed · 2011 · Journal Article
- MicroRNA-223 expression in neutrophils in the early phase of secondary damage after spinal cord injury. — PubMed · 2011 · Journal Article
- Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. — PubMed · 2011 · Journal Article
- Down-regulation of glutamine synthetase enhances migration of rat astrocytes after in vitro injury. — PubMed · 2011 · Journal Article
- Activated microglia inhibit axonal growth through RGMa. — PubMed · 2011 · Journal Article
- FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels. — PubMed · 2010 · Journal Article
- Cycling exercise affects the expression of apoptosis-associated microRNAs after spinal cord injury in rats. — PubMed · 2010 · Journal Article
- Comparative profiling of microRNA expression between neural stem cells and motor neurons in embryonic spinal cord in rat. — PubMed · 2010 · Comparative Study
- Involvement of ERK2 in traumatic spinal cord injury. — PubMed · 2010 · Journal Article
- Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. — PubMed · 2010 · Journal Article
- Responses of microRNAs 124a and 223 following spinal cord injury in mice. — PubMed · 2010 · Journal Article
- BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury. — PubMed · 2010 · Journal Article
- [Construction and screening of neurite outgrowth inhibitory 66 eukaryotic expression vectors]. — PubMed · 2010 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])