A subject this map covers
Antisense oligonucleotides and RNA therapy
Part of: Gene therapy
What belongs here
RNA molecules or their analogues given to change how a gene works after injury.
What does not belong here, however close it looks
MicroRNA as a biomarker without intervention is diagnostics, not therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 262 records · 1997–2026
- Indexed as work in animals: 612 records · 2000–2026
- Indexed as laboratory work: 28 records · 2007–2024
- The source has not said who or what was studied: 173 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1075 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- A molecular mechanism for ibuprofen-mediated RhoA inhibition in neurons. — PubMed · 2010 · Journal Article
- [Treatment of spinal cord injury by transplanting neural stem cells with NgR gene silencing]. — PubMed · 2010 · Journal Article
- Altered microRNA expression following traumatic spinal cord injury. — PubMed · 2009 · Journal Article
- The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. — PubMed · 2009 · Journal Article
- The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells. — PubMed · 2009 · Journal Article
- De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. — PubMed · 2009 · Journal Article
- Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. — PubMed · 2008 · Journal Article
- Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons. — PubMed · 2008 · Journal Article
- Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury. — PubMed · 2008 · Journal Article
- Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes. — PubMed · 2008 · Comparative Study
- Chondroitin-4-sulfation negatively regulates axonal guidance and growth. — PubMed · 2008 · Journal Article
- Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury. — PubMed · 2008 · Journal Article
- Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule. — PubMed · 2008 · Journal Article
- Transforming growth factor-beta1 regulates the fate of cultured spinal cord-derived neural progenitor cells. — PubMed · 2008 · Journal Article
- Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury. — PubMed · 2008 · Journal Article
- Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. — PubMed · 2008 · Journal Article
- A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats. — PubMed · 2008 · Journal Article
- Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation. — PubMed · 2008 · Journal Article
- Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. — PubMed · 2007 · Journal Article
- Effects of single versus combinatorial treatment strategies on beta II-tubulin gene expression in axotomized hamster rubrospinal motoneurons. — PubMed · 2007 · Journal Article
- Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain. — PubMed · 2006 · Comparative Study
- Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery. — PubMed · 2006 · Comparative Study
- Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. — PubMed · 2006 · Journal Article
- Antisense oligos to neuronal nitric oxide synthase aggravate motoneuron death induced by spinal root avulsion in adult rat. — PubMed · 2006 · Journal Article
- JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury. — PubMed · 2005 · Journal Article
- Changes in electrophysiological properties and sodium channel Nav1.3 expression in thalamic neurons after spinal cord injury. — PubMed · 2005 · Journal Article
- A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. — PubMed · 2005 · Journal Article
- Inhibition of tumour necrosis factor-alpha by antisense targeting produces immunophenotypical and morphological changes in injury-activated microglia and macrophages. — PubMed · 2004 · Comparative Study
- Regulation of semaphorin 3A expression in neurons of the rat spinal cord and cerebral cortex after transection injury. — PubMed · 2004 · Comparative Study
- Comparison of iNOS inhibition by antisense and pharmacological inhibitors after spinal cord injury. — PubMed · 2003 · Comparative Study
- Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. — PubMed · 2003 · Journal Article
- [Role of antisense oligodeoxynucleotide of inducible nitric oxide synthase in the apoptosis and p-p38 MAPK signal transduction in rat neurons after spinal cord injury]. — PubMed · 2003 · English Abstract
- Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury. — PubMed · 2001 · Journal Article
- Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat. — PubMed · 2000 · Journal Article
Indexed as laboratory work
- Ginsenoside Rg1 regulates astrocytes to promote angiogenesis in spinal cord injury via the JAK2/STAT3 signaling pathway. — PubMed · 2024 · Journal Article
- miR-NPs-RVG promote spinal cord injury repair: implications from spinal cord-derived microvascular endothelial cells. — PubMed · 2024 · Journal Article
- Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment. — PubMed · 2023 · Journal Article
- Upregulation of miR‑128 inhibits neuronal cell apoptosis following spinal cord injury via FasL downregulation by repressing ULK1. — PubMed · 2021 · Journal Article
- MicroRNA-223 targets NLRP3 to relieve inflammation and alleviate spinal cord injury. — PubMed · 2020 · Journal Article
- miR-22-3p enhances the intrinsic regenerative abilities of primary sensory neurons via the CBL/p-EGFR/p-STAT3/GAP43/p-GAP43 axis. — PubMed · 2020 · Journal Article
- Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis. — PubMed · 2020 · Journal Article
- Transplantation of miR-219 overexpressed human endometrial stem cells encapsulated in fibrin hydrogel in spinal cord injury. — PubMed · 2019 · Journal Article
- MiR-124 inhibits spinal neuronal apoptosis through binding to GCH1. — PubMed · 2019 · Journal Article
- MiR-137-5p alleviates inflammation by upregulating IL-10R1 expression in rats with spinal cord injury. — PubMed · 2019 · Journal Article
- MicroRNA-204-5p targets SOX11 to regulate the inflammatory response in spinal cord injury. — PubMed · 2019 · Journal Article
- Low frequency pulsed electromagnetic field promotes differentiation of oligodendrocyte precursor cells through upregulation of miR-219-5p in vitro. — PubMed · 2019 · Journal Article
- MiR-92b-5p inhibitor suppresses IL-18 mediated inflammatory amplification after spinal cord injury via IL-18BP up-regulation. — PubMed · 2019 · Journal Article
- MicroRNA-212 inhibits oligodendrocytes during maturation by down-regulation of differentiation-associated gene expression. — PubMed · 2017 · Journal Article
- RNAi-mediated ephrin-B2 silencing attenuates astroglial-fibrotic scar formation and improves spinal cord axon growth. — PubMed · 2017 · Journal Article
- Regulation of RhoA by STAT3 coordinates glial scar formation. — PubMed · 2017 · Journal Article
- Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling. — PubMed · 2017 · Journal Article
- Non-viral xylosyltransferase-1 siRNA delivery as an effective alternative to chondroitinase in an in vitro model of reactive astrocytes. — PubMed · 2016 · Journal Article
- The importance of EHD1 in neurite outgrowth contributing to the functional recovery after spinal cord injury. — PubMed · 2016 · Journal Article
- eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach. — PubMed · 2015 · Journal Article
- PERK pathway is involved in oxygen-glucose-serum deprivation-induced NF-kB activation via ROS generation in spinal cord astrocytes. — PubMed · 2015 · Journal Article
- TCTP Expression After Rat Spinal Cord Injury: Implications for Astrocyte Proliferation and Migration. — PubMed · 2015 · Journal Article
- Permissive role of Cdc2 activity induced from astrocytes in neurite outgrowth. — PubMed · 2013 · Journal Article
- Curcumin attenuates the expression and secretion of RANTES after spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro. — PubMed · 2011 · Journal Article
- Lentiviral vector-mediated knockdown of the NG2 [corrected] proteoglycan or expression of neurotrophin-3 promotes neurite outgrowth in a cell culture model of the glial scar. — PubMed · 2010 · Journal Article
- A model for ex vivo spinal cord segment culture--a tool for analysis of injury repair strategies. — PubMed · 2010 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 854026 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-05 | the source found 2 · this programme has 1046 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("antisense oligonucleotide" OR "siRNA" OR "microRNA") - Crossref
spinal cord injury antisense oligonucleotide siRNA - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Oligonucleotides, Antisense"[MeSH Terms] OR "RNA, Small Interfering"[MeSH Terms] OR "MicroRNAs"[MeSH Terms] OR "antisense oligonucleotide"[Title/Abstract] OR "siRNA"[Title/Abstract] OR "microRNA"[Title/Abstract])