A subject this map covers
Glial scar and its remodelling
What belongs here
The tissue that forms around the lesion, and attempts to change it — soften, remodel or use it.
What does not belong here, however close it looks
Skin or soft-tissue scarring after surgery does not belong here.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 478 records · 1963–2026
- Indexed as work in animals: 879 records · 1969–2026
- Indexed as laboratory work: 59 records · 1992–2026
- The source has not said who or what was studied: 294 records · 1983–2026
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
1710 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model. — PubMed · 2025 · Journal Article
- Hyaluronan-bisphosphonate conjugate: A macromolecular anti-inflammatory agent and gas delivery system for neuroimmunomodulation in spinal cord injury. — PubMed · 2025 · Journal Article
- Incorporation of graphene oxide into collagenous biomaterials attenuates scar-forming phenotype transition of reactive astrocytes in vitro. — PubMed · 2025 · Journal Article
- Nanodrug-loaded microneedles promote scar-reduced repair after spinal cord injury by re-establishing microglial homeostasis. — PubMed · 2025 · Journal Article
- Acute Extrinsic Activation of the RANKL Pathway Decreases Wound Healing and Functional Recovery After Spinal Cord Injury in Mice. — PubMed · 2025 · Journal Article
- Olfactory ensheathing cells from adult female rats are hybrid glia that promote neural repair. — PubMed · 2025 · Journal Article
- Body weight-supported treadmill training reduces glial scar overgrowth in SCI rats by decreasing the reactivity of astrocytes during the subacute phase. — PubMed · 2025 · Journal Article
- Repeated Administrations of Polyphenolic Extracts Prevent Chronic Reflexive and Non-Reflexive Neuropathic Pain Responses by Modulating Gliosis and CCL2-CCR2/CX3CL1-CX3CR1 Signaling in Spinal Cord-Injured Female Mice. — PubMed · 2025 · Journal Article
- SGK1 upregulation in GFAP(+) neurons in the frontal association cortex protects against neuronal apoptosis after spinal cord injury. — PubMed · 2025 · Journal Article
- Combined treatment targeting Ca2+ store mediated Ca2+ release and store-operated calcium entry reduces secondary axonal degeneration and improves functional outcome after SCI. — PubMed · 2025 · Journal Article
- Targeting Nerve Fiber Outgrowth Inhibition After Experimental Spinal Cord Injury: A Systematic Review and Meta-analysis of Chondroitinase ABC. — PubMed · 2025 · Journal Article
- Electroacupuncture Improves the Motor Function in Rats with Spinal Cord Injury by Regulating UCN2-Mediated cAMP-PKA Signaling in the Spinal Cord Microenvironment. — PubMed · 2025 · Journal Article
- Metformin's therapeutic potential in spinal cord injury: a systematic review and meta-analysis on locomotor recovery, neuropathic pain alleviation, and modulation of secondary injury mechanisms. — PubMed · 2025 · Journal Article
- Calycosin regulates astrocyte reactivity and astrogliosis after spinal cord injury by targeting STAT3 phosphorylation. — PubMed · 2025 · Journal Article
- Mesenchymal stem cells overexpressing neuropeptide S promote the recovery of rats with spinal cord injury by activating the PI3K/AKT/GSK3β signaling pathway. — PubMed · 2025 · Journal Article
- Resveratrol loaded microglia-derived exosomes attenuate astrogliasis by restoring mitochondrial function to reduce spinal cord injury. — PubMed · 2025 · Journal Article
- Fecal microbiota transplantation promotes functional recovery in mice with spinal cord injury by modulating the spinal cord microenvironment. — PubMed · 2025 · Journal Article
- Demonstration of therapeutic effect of plasma-synthesized polypyrrole/iodine biopolymer in rhesus monkey with complete spinal cord section. — PubMed · 2025 · Journal Article
- Transcranial alternating current stimulation inhibits ferroptosis and promotes functional recovery in spinal cord injury via the cGMP-PKG signalling pathway. — PubMed · 2025 · Journal Article
- Transtraumatic Epidural Electrostimulation Promotes the Preservation of the Spinal Cord and Skeletal Muscles in Pigs. — PubMed · 2025 · Journal Article
- Nitric Oxide-Releasing Mesoporous Hollow Cerium Oxide Nanozyme-Based Hydrogel Synergizes with Neural Stem Cell for Spinal Cord Injury Repair. — PubMed · 2025 · Journal Article
- Application of Adipose Extracellular Matrix and Reduced Graphene Oxide Nanocomposites for Spinal Cord Injury Repair. — PubMed · 2025 · Journal Article
- Electroacupuncture stimulation inhibited astrogliosis and microglia polarisation to alleviate spinal cord injury via Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. — PubMed · 2025 · Journal Article
- Combined biomaterial scaffold and neuromodulation strategy to promote tissue repair and corticospinal connectivity after spinal cord injury in a rodent model. — PubMed · 2024 · Journal Article
- Lycium barbarum oligosaccharide-derived carbon quantum dots inhibit glial scar formation while promoting neuronal differentiation of neural stem cells. — PubMed · 2024 · Journal Article
- Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice. — PubMed · 2024 · Journal Article
- Tissue-Adaptive BSA Hydrogel with Dual Release of PTX and bFGF Promotes Spinal Cord Injury Repair via Glial Scar Inhibition and Axon Regeneration. — PubMed · 2024 · Journal Article
- A critical role for microglia in regulating metabolic homeostasis and neural repair after spinal cord injury. — PubMed · 2024 · Journal Article
- Lentivirus-mediated Knockdown of Ski Improves Neurological Function After Spinal Cord Injury in Rats. — PubMed · 2024 · Journal Article
- Biomimetic Multichannel Silk Nerve Conduits With Multicellular Spatiotemporal Distributions for Spinal Cord Injury Repair. — PubMed · 2024 · Journal Article
- Regulating Astrocytes via Short Fibers for Spinal Cord Repair. — PubMed · 2024 · Journal Article
- Curcumin/pEGCG-encapsulated nanoparticles enhance spinal cord injury recovery by regulating CD74 to alleviate oxidative stress and inflammation. — PubMed · 2024 · Journal Article
- Astrocyte-derived lipocalin 2 promotes inflammation and scarring after spinal cord injury by activating SMAD in mice. — PubMed · 2024 · Journal Article
- Endogenous opioid signalling regulates spinal ependymal cell proliferation. — PubMed · 2024 · Journal Article
- Involvement of vimentin- and BLBP-positive glial cells and their MMP expression in axonal regeneration after spinal cord transection in goldfish. — PubMed · 2024 · Journal Article
- NEMO-Binding Domain/IKKγ Inhibitory Peptide Alleviates Neuronal Pyroptosis in Spinal Cord Injury by Inhibiting ASMase-Induced Lysosome Membrane Permeabilization. — PubMed · 2024 · Journal Article
- Conductive Hydrogel Restores Electrical Conduction to Promote Neurological Recovery in a Rat Model. — PubMed · 2024 · Journal Article
- Microglia-mediated pericytes migration and fibroblast transition via S1P/S1P3/YAP signaling pathway after spinal cord injury. — PubMed · 2024 · Journal Article
- miR-540-3p partially recovers the locomotor function of spinal cord injury mice by targeting SIX4/Yap1 and inactivation of astrocytes. — PubMed · 2024 · Journal Article
- Tetramethylpyrazine alleviates ferroptosis and promotes functional recovery in spinal cord injury by regulating GPX4/ACSL4. — PubMed · 2024 · Journal Article
- Neuronal repair after spinal cord injury by in vivo astrocyte reprogramming mediated by the overexpression of NeuroD1 and Neurogenin-2. — PubMed · 2024 · Journal Article
- Transplantation of Predegenerated Peripheral Nerves after Complete Spinal Cord Transection in Rats: Effect of Neural Precursor Cells and Pharmacological Treatment with the Sulfoglycolipid Tol-51. — PubMed · 2024 · Journal Article
- Lactate promotes microglial scar formation and facilitates locomotor function recovery by enhancing histone H4 lysine 12 lactylation after spinal cord injury. — PubMed · 2024 · Journal Article
- Fucoidan improving spinal cord injury recovery: Modulating microenvironment and promoting remyelination. — PubMed · 2024 · Journal Article
- Schwann Cell-Derived Exosomes Induced Axon Growth after Spinal Cord Injury by Decreasing PTP-σ Activation on CSPGs via the Rho/ROCK Pathway. — PubMed · 2024 · Journal Article
- The Porous SilMA Hydrogel Scaffolds Carrying Dual-Sensitive Paclitaxel Nanoparticles Promote Neuronal Differentiation for Spinal Cord Injury Repair. — PubMed · 2024 · Journal Article
- Heterogeneous fibroblasts contribute to fibrotic scar formation after spinal cord injury in mice and monkeys. — PubMed · 2024 · Journal Article
- Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction. — PubMed · 2024 · Journal Article
- Regeneration of Propriospinal Axons in Rat Transected Spinal Cord Injury through a Growth-Promoting Pathway Constructed by Schwann Cells Overexpressing GDNF. — PubMed · 2024 · Journal Article
- Neuroimmune modulating and energy supporting nanozyme-mimic scaffold synergistically promotes axon regeneration after spinal cord injury. — PubMed · 2024 · Journal Article
- Comparative model of minimal spinal cord injury reveals a rather anti-inflammatory response in the lesion site as well as increased proliferation in the central canal lining in the neonates compared to the adult rats. — PubMed · 2024 · Journal Article
- Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice. — PubMed · 2024 · Journal Article
- Galectin-3 absence alters lymphocytes populations dynamics behavior and promotes functional recovery after spinal cord injury in mice. — PubMed · 2024 · Journal Article
- Therapeutic application of nicotinamide: As a potential target for inhibiting fibrotic scar formation following spinal cord injury. — PubMed · 2024 · Journal Article
- Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform. — PubMed · 2024 · Journal Article
- NT-3 Combined with TGF-β Signaling Pathway Enhance the Repair of Spinal Cord Injury by Inhibiting Glial Scar Formation and Promoting Axonal Regeneration. — PubMed · 2024 · Journal Article
- Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury. — PubMed · 2024 · Journal Article
- Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord. — PubMed · 2024 · Journal Article
- Cypin Inhibition as a Therapeutic Approach to Treat Spinal Cord Injury-Induced Mechanical Pain. — PubMed · 2024 · Journal Article
- The TGFβ1/SMADs/Snail1 signaling axis mediates pericyte-derived fibrous scar formation after spinal cord injury. — PubMed · 2024 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 4 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 851162 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 7 · this programme has 1725 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("glial scar" OR "astrogliosis" OR "fibrotic scar") - Crossref
spinal cord injury glial scar astrogliosis - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Gliosis"[MeSH Terms] OR "Cicatrix"[MeSH Terms] OR "glial scar"[Title/Abstract] OR "astrogliosis"[Title/Abstract] OR "fibrotic scar"[Title/Abstract])