A subject this map covers
Inflammation and immune response
What belongs here
What immune cells do after injury — both as damage and as a necessary part of healing.
What does not belong here, however close it looks
Infection and sepsis are clinical management, a separate subject.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 769 records · 1981–2027
- Indexed as work in animals: 1704 records · 1975–2027
- Indexed as laboratory work: 73 records · 2001–2026
- The source has not said who or what was studied: 639 records · 1998–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3185 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury. — PubMed · 2022 · Journal Article
- Microglial deactivation by adeno-associated virus expressing small-hairpin GCH1 has protective effects against neuropathic pain development in a spinothalamic tract-lesion model. — PubMed · 2022 · Journal Article
- Perforin affects regeneration in a mouse spinal cord injury model. — PubMed · 2022 · Journal Article
- Phoenixin-14 Promotes the Recovery of Neurological Dysfunction After Spinal Cord Injury by Regulating Microglial Polarization via PTEN/Akt Signaling Pathway. — PubMed · 2022 · Journal Article
- Inhibition of Bruton Tyrosine Kinase Reduces Neuroimmune Cascade and Promotes Recovery after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy. — PubMed · 2021 · Journal Article
- Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration. — PubMed · 2021 · Journal Article
- Bone mesenchymal stem cell-derived extracellular vesicles deliver microRNA-23b to alleviate spinal cord injury by targeting toll-like receptor TLR4 and inhibiting NF-κB pathway activation. — PubMed · 2021 · Journal Article
- Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation. — PubMed · 2021 · Journal Article
- CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway. — PubMed · 2021 · Journal Article
- Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84. — PubMed · 2021 · Journal Article
- Exerting the Appropriate Application of Methylprednisolone in Acute Spinal Cord Injury Based on Time Course Transcriptomics Analysis. — PubMed · 2021 · Journal Article
- Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2. — PubMed · 2021 · Journal Article
- High mobility group box-1 serves a pathogenic role in spinal cord injury via the promotion of pro-inflammatory cytokines. — PubMed · 2021 · Journal Article
- IGF1 Gene Therapy Reversed Cognitive Deficits and Restored Hippocampal Alterations After Chronic Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice. — PubMed · 2021 · Journal Article
- Inhibition of miR-145-5p Reduces Spinal Cord Injury-Induced Inflammatory and Oxidative Stress Responses via Affecting Nurr1-TNF-α Signaling Axis. — PubMed · 2021 · Journal Article
- MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3). — PubMed · 2021 · Journal Article
- Nerve Excitability and Neuropathic Pain is Reduced by BET Protein Inhibition After Spared Nerve Injury. — PubMed · 2021 · Journal Article
- Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats. — PubMed · 2021 · Journal Article
- Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling. — PubMed · 2021 · Journal Article
- RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate. — PubMed · 2021 · Journal Article
- Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day. — PubMed · 2021 · Journal Article
- Optimizing fibrin hydrogel toward effective neural progenitor cell delivery in spinal cord injury. — PubMed · 2021 · Journal Article
- Regulation of Inflammasomes by Application of Omega-3 Polyunsaturated Fatty Acids in a Spinal Cord Injury Model. — PubMed · 2021 · Journal Article
- Chondroitin 6-sulfate-binding peptides improve recovery in spinal cord-injured mice. — PubMed · 2021 · Journal Article
- Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats. — PubMed · 2021 · Journal Article
- Lipocalin 2 as a Putative Modulator of Local Inflammatory Processes in the Spinal Cord and Component of Organ Cross talk After Spinal Cord Injury. — PubMed · 2021 · Journal Article
- MSC derived EV loaded with miRNA-22 inhibits the inflammatory response and nerve function recovery after spinal cord injury in rats. — PubMed · 2021 · Journal Article
- Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses. — PubMed · 2021 · Journal Article
- Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Tomographic Imaging and Correlation to Quantify Vascular and Inflammatory Changes in an Experimental Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Disrupting RhoA activity by blocking Arhgef3 expression mitigates microglia-induced neuroinflammation post spinal cord contusion. — PubMed · 2021 · Journal Article
- Polydopamine-Decorated Microcomposites Promote Functional Recovery of an Injured Spinal Cord by Inhibiting Neuroinflammation. — PubMed · 2021 · Journal Article
- Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury. — PubMed · 2021 · Journal Article
- Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury. — PubMed · 2021 · Journal Article
- Ameliorative effects of miR-423-5p against polarization of microglial cells of the M1 phenotype by targeting a NLRP3 inflammasome signaling pathway. — PubMed · 2021 · Journal Article
- IgM Immunoglobulin Influences Recovery after Cervical Spinal Cord Injury by Modulating the IgG Autoantibody Response. — PubMed · 2021 · Journal Article
- Ferulic acid improves motor function induced by spinal cord injury in rats via inhibiting neuroinflammation and apoptosis. — PubMed · 2021 · Journal Article
- Cervical spinal cord injury-induced neuropathic pain in male mice is associated with a persistent pro-inflammatory macrophage/microglial response in the superficial dorsal horn. — PubMed · 2021 · Journal Article
- Effects of Gynostemma pentaphyllum on spinal cord motor neurons and microglial cells in vitro. — PubMed · 2021 · Journal Article
- [Necrostatin-1 promotes locomotor recovery after spinal cord injury through inhibiting apoptosis and M1 polarization of microglia/macrophage in mice]. — PubMed · 2021 · Journal Article
- Proton-sensing receptor GPR132 facilitates migration of astrocytes. — PubMed · 2021 · Journal Article
- S100-β aggravates spinal cord injury via activation of M1 macrophage phenotype. — PubMed · 2021 · Journal Article
- [Effect of electroacupuncture of "Zhiyang" (GV9) and "Jizhong" (GV6) on expression of CGRP and NLRP3 in rats with spinal cord injury]. — PubMed · 2021 · Journal Article
- Keratin Biomaterials Improve Functional Recovery in a Rat Spinal Cord Injury Model. — PubMed · 2021 · Journal Article
- Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Effect of Cannabinoid 2 Receptor Modulation on the Peripheral Immune Response in Central Nervous System Injury-Induced Immunodeficiency Syndrome. — PubMed · 2021 · Journal Article
- Gramine promotes functional recovery after spinal cord injury via ameliorating microglia activation. — PubMed · 2021 · Journal Article
- Peptide Hydrogel Scaffold for Mesenchymal Precursor Cells Implanted to Injured Adult Rat Spinal Cord. — PubMed · 2021 · Journal Article
- Up-regulation of miR-338-5p after spinal cord injury enhances the neuronal repair via inhibition of inflammation aggravation and oxidative stress. — PubMed · 2021 · Letter
- Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates. — PubMed · 2021 · Journal Article
- Activation of Neuroprotective Microglia and Astrocytes at the Lesion Site and in the Adjacent Segments Is Crucial for Spontaneous Locomotor Recovery after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma. — PubMed · 2021 · Journal Article
- CXCL12 inhibits inflammasome activation in LPS-stimulated BV2 cells. — PubMed · 2021 · Journal Article
- Effect of humic acid on oxidative stress and neuroprotection in traumatic spinal cord injury: an experimental study. — PubMed · 2021 · Journal Article
- The Conditioned Medium of Lactobacillus rhamnoides GG Regulates Microglia/Macrophage Polarization and Improves Functional Recovery after Spinal Cord Injury in Rats. — PubMed · 2021 · Journal Article The source marks this record as retracted.
- Proteomics and bioinformatics reveal insights into neuroinflammation in the acute to subacute phases in rat models of spinal cord contusion injury. — PubMed · 2021 · Journal Article
- The Protein Kinase Inhibitor Midostaurin Improves Functional Neurological Recovery and Attenuates Inflammatory Changes Following Traumatic Cervical Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota. — PubMed · 2021 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 3 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 851312 · accumulated records across collection walks 48 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 Collection window: 2026-09-17 – 2026-10-12 | matched in this collection walk 29 · accumulated records across collection walks 3219 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroinflammation" OR "microglia" OR "immune response") - Crossref
spinal cord injury neuroinflammation microglia - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neurogenic Inflammation"[MeSH Terms] OR "Microglia"[MeSH Terms] OR "Neuroimmunomodulation"[MeSH Terms] OR "neuroinflammation"[Title/Abstract] OR "microglia"[Title/Abstract] OR "immune response"[Title/Abstract])