A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Extracellular Vesicle-Mediated Precision Delivery of Paclitaxel Activates Mitophagy to Promote Repair after Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Injectable hydrogel-based localized delivery of IDO-galectin-3 mitigates neuroinflammation and promotes neuronal sparing after spinal cord contusion in rats. — PubMed · 2026 · Journal Article
- Application of hyperbaric oxygen therapy in the treatment of spinal cord injury: insights from preclinical to clinical evidence. — PubMed · 2026 · Journal Article
- A proactive cholinergic-like acidic fibroblast growth factor delivery system for efficient protein enrichment and native drug release in the central nervous system to promote repair of injured spinal cord. — PubMed · 2026 · Journal Article
- Efficient generation of human dorsal spinal GABAergic progenitors for the treatment of spinal cord injury. — PubMed · 2026 · Journal Article
- Exosome-Loaded Engineered circBDNF Promotes Spinal Cord Injury Repair Through the PI3K/AKT/mTOR Signaling Axis. — PubMed · 2026 · Journal Article
- Recent advances in the application of engineered extracellular vesicles from mesenchymal stem cells for traumatic central nervous system. — PubMed · 2026 · Journal Article
- Pharmacological and device-based interventions for paraplegia: A ClinicalTrials.gov-based analysis. — PubMed · 2026 · Journal Article
- Current Advancements in the Arsenal for Spinal Cord Injury Repair: Novel Drug Formulations. — PubMed · 2026 · Journal Article
- PANoptosis: a new perspective for targeting programmed cell death after spinal cord injury. — PubMed · 2026 · Journal Article
- Fascin-1 Limits Secondary Damage by Preventing Oxidative‑Stress‑Induced Microglial Death After Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats. — PubMed · 2026 · Journal Article
- Targeting spinal cord perfusion pressure in acute spinal cord injury through cerebrospinal fluid drainage: A prospective multi-center clinical trial. — PubMed · 2026 · Journal Article
- Regeneration and remyelination promoting effects of spinal cord stimulation following spinal cord injury: A scoping review. — PubMed · 2026 · Journal Article
- Nanomaterial-based therapeutic strategies for spinal cord injury repair: harnessing multifunctionality to overcome pathophysiological challenges. — PubMed · 2026 · Journal Article
- Celastrol as a neuroprotective drug: current status and challenges. — PubMed · 2026 · Journal Article
- GPCRs in traumatic brain or spinal injury. — PubMed · 2026 · Journal Article
- Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury — ClinicalTrials.gov · 2026 · Interventional · Not Yet Recruiting
- Nano-shields: Exploring the role of antioxidant mimicking nanoparticles as regenerative therapy in spinal cord injury. — PubMed · 2026 · Journal Article
- Therapeutic Hypothermia for Neurological Injuries: Balancing Neuroprotection with Risks. — PubMed · 2026 · Journal Article
- Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Strategy for Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Beyond Fuel: Exercise-Induced Lactate as a Metabolic-Epigenetic Regulator in Central Nervous System Health and Disease. — PubMed · 2025 · Journal Article
- Mechanism analysis and intervention strategies of the inflammatory microenvironment in traumatic spinal cord injury. — PubMed · 2025 · Journal Article
- Inorganic, Synthetic, Natural, and Innovative Hybrid Hydrogen Sulfide Donors and Inhibitors of Its Biosynthesis in the Treatment of Central and Peripheral Nervous System Injuries: A Systematic Analytical Review. — PubMed · 2025 · Journal Article
- Extracellular vesicle-derived MicroRNAs as potential therapies for spinal cord and peripheral nerve injuries. — PubMed · 2025 · Journal Article
- Recent advances in nanotechnology for repairing spinal cord injuries. — PubMed · 2025 · Journal Article
- Riluzole as a pharmacological therapy for spinal cord injury: where does this therapy stand? — PubMed · 2025 · Journal Article
- The forgotten inflammasomes: AIM2, NLRP1, and NLRC4 in spinal cord injury and neuroinflammation. — PubMed · 2025 · Journal Article
- The Mechanobiological Hypothesis of Piezo Family-Mediated Exercise Intervention in Spinal Cord Injury Recovery. — PubMed · 2025 · Journal Article
- Circulating microRNA Profiles in Acute Spinal Cord Injury: Evidence for Distinct Plasma Signatures Compared with Polytrauma Patients. — PubMed · 2025 · Journal Article
- Application and challenge of Schwann cell transplantation in spinal cord injury and clinical trial. — PubMed · 2025 · Journal Article
- Enhancing spinal cord injury recovery with functional liposomal nanomedicine: A neuroprotective and anti-inflammatory approach. — PubMed · 2025 · Journal Article
- Glutamate Excitotoxicity: A Key Secondary Injury Mechanism of Traumatic Brain Injury and Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Galanin regulates M1/M2 polarization of microglia after spinal cord injury through TRPV1/Ca2+/CaMKII/NRF2 signaling pathway. — PubMed · 2025 · Journal Article
- Cerebrospinal fluid extracellular vesicle-derived miR-9-3p in spinal cord injury with neuroprotective implications and biomarker development. — PubMed · 2025 · Journal Article
- Identification of genes associated with disulfidptosis in the subacute phase of spinal cord injury and analysis of potential therapeutic targets. — PubMed · 2025 · Journal Article
- Hormonal regulatory networks in spinal cord injury: mechanistic insights, crosstalk, and therapeutic innovations. — PubMed · 2025 · Journal Article
- Mechanisms underpinning spontaneous spinal cord regeneration. — PubMed · 2025 · Journal Article
- RNA Interference and Its Key Targets for Spinal Cord Injury Therapy: What Is Known So Far? — PubMed · 2025 · Journal Article
- Biomaterials and cell-based therapy post spinal cord injury. — PubMed · 2025 · Journal Article
- Dl-3-n-Butylphthalide Inhibits Autophagy to Alleviate the Neuronal Apoptosis After Spinal Cord Injury by Elevating YAP via Inactivating the Hippo Signaling Pathway. — PubMed · 2025 · Journal Article
- Pharmacological landscape of linarin: From benchside mechanisms to potential bedside applications. — PubMed · 2025 · Journal Article
- The neuroinflammatory triumvirate: NF-κB, NLRP3, and mTOR in spinal cord injury. — PubMed · 2025 · Journal Article
- Disruptions in nitric oxide homeostasis, lipid peroxidation-derived oxidative stress, and antioxidant defense mechanisms in spinal cord injury: elucidating biomolecular correlates of disease severity. — PubMed · 2025 · Journal Article
- Calpains at the Crossroads of Spinal Cord Physiology, Plasticity, and Pathology. — PubMed · 2025 · Journal Article
- Mechanisms and parameters of photobiomodulation for neurological and neuropsychiatric disorders: whether and how to apply? — PubMed · 2025 · Journal Article
- How Advanced Are Exosomes as Cell-Free Therapeutics for Spinal Cord Injury? — PubMed · 2025 · Journal Article
- Selenized neural stem cell-derived exosomes: A neotype therapeutic agent for traumatic injuries of the central nervous system. — PubMed · 2025 · Journal Article
- A review of bigels for neurotrauma therapeutics: Structural insights for tissue microenvironment alignment. — PubMed · 2025 · Journal Article
- Reactive astrocytes in spinal cord injury: An analysis of heterogeneity based on temporality and spatiality, potential therapies, and limitations. — PubMed · 2025 · Journal Article
- Relaxin-2 Ameliorates Spinal Cord Injury by Inhibiting Microglia Activation. — PubMed · 2025 · Journal Article
- Regulatory effect of inflammatory mediators in spinal cord injury. — PubMed · 2025 · Journal Article
- Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions. — PubMed · 2025 · Journal Article
- Exosomes Derived from Tanshinone IIA-Pretreated Umbilical Cord Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by miR-223-5p/USP8/NLRP3 Axis. — PubMed · 2025 · Journal Article
- Application and current challenges of neural stem cells transplantation in clinical trials of spinal cord injury. — PubMed · 2025 · Journal Article
- CircGTF2H2C Regulates NLRP3 Dephosphorylation via Modulating PTPN11 Expression in Spinal Cord Injury. — PubMed · 2025 · Journal Article
- Neuroprotective Potential of Curcumin in Neurodegenerative Diseases: Clinical Insights Into Cellular and Molecular Signaling Pathways. — PubMed · 2025 · Journal Article
- Targeting JAK/STAT signaling pathway by curcumin: implications for spinal cord injury neuroprotection. — PubMed · 2025 · Journal Article
- The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique. — PubMed · 2025 · Journal Article
- Precision Recovery After Spinal Cord Injury: Integrating CRISPR Technologies, AI-Driven Therapeutics, Single-Cell Omics, and System Neuroregeneration. — PubMed · 2025 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 6 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1230843 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 3744 · this programme has 3744 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])