A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as laboratory work
- The neuroprotective potential of phase II enzyme inducer on motor neuron survival in traumatic spinal cord injury in vitro. — PubMed · 2008 · Journal Article
- Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: heat shock protein 70 levels are modulated in microglial cells. — PubMed · 2008 · Journal Article
- Chronic erythropoietin-mediated effects on the expression of astrocyte markers in a rat model of contusive spinal cord injury. — PubMed · 2008 · Journal Article
- Hypothermia suppresses excitatory synaptic transmission and neuronal death induced by experimental ischemia in spinal ventral horn neurons. — PubMed · 2007 · Journal Article
- Characterization and modeling of monocyte-derived macrophages after spinal cord injury. — PubMed · 2007 · Journal Article
- Astroglia-mediated effects of uric acid to protect spinal cord neurons from glutamate toxicity. — PubMed · 2007 · Journal Article
- Bone marrow stromal cells for repair of the spinal cord: towards clinical application. — PubMed · 2006 · Journal Article
- Neuroprotection following fluid percussion brain trauma: a pilot study using quercetin. — PubMed · 2005 · Journal Article
- Novel small peptides with neuroprotective and nootropic properties. — PubMed · 2004 · Journal Article
- An in vitro model of neurotrauma in organotypic spinal cord cultures from adult mice. — PubMed · 2002 · Journal Article
- Heme oxygenase-1 expression after spinal cord injury: the induction in activated neutrophils. — PubMed · 2002 · Journal Article
- Cellular engineering: molecular repair of membranes to rescue cells of the damaged nervous system. — PubMed · 2001 · Journal Article
- No protective effect of the NMDA antagonist memantine in experimental spinal cord injuries. — PubMed · 1997 · Journal Article
- Mechanisms of secondary injury to spinal cord axons in vitro: role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger. — PubMed · 1996 · Journal Article
The source has not said who or what was studied
- Therapeutic potential of concentrated growth factor for spinal cord injury: Targeting microglial polarization and inflammation regulation. — PubMed · 2026 · Journal Article
- Spatiotemporal disarray of inflammatory microenvironment following spinal cord injury. — PubMed · 2026 · Journal Article
- Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9. — PubMed · 2026 · Journal Article
- An H₂O₂/Acidic microenvironment-responsive theranostic nanoplatform promotes spinal cord injury repair via MRI-guided synergistic anti-ferroptosis. — PubMed · 2026 · Journal Article
- M2 polarization of macrophages: Manipulation of spinal cord injury repair. — PubMed · 2026 · Journal Article
- A Bibliometric Analysis of Mitochondrial Dysfunction in Spinal Cord Injury: Research Landscape and Emerging Trends, 2000-2025. — PubMed · 2026 · Journal Article
- Multi-omics identifies a VIM-associated microglial program linked to lactylation, ferroptosis, and neuroinflammation after spinal cord injury. — PubMed · 2026 · Journal Article
- Contrast-Enhanced Ultrasound Demonstrates a Severity-Dependent Hemodynamic Response to Acute Dural Decompression in Contusive Rodent Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Editorial: Molecular and cellular mechanisms underpinning adaptation and recovery after spinal cord injury. — PubMed · 2026 · Editorial
- Beyond the Diagnosis: An Integrated Perspective on Strategic Dosing in Neurologic Motor Rehabilitation. A Scoping Review and Collaborative Viewpoint. — PubMed · 2026 · Journal Article
- Hierarchical targeting biomimetic nanoparticles directing to lesion site and mitochondria promote neuroregeneration and attenuate inflammation after spinal cord injury. — PubMed · 2026 · Journal Article
- Conditional deletion of Bmal1 modestly alters acute pathology without affecting functional recovery after contusive spinal cord injury. — PubMed · 2026 · Journal Article
- Reprogramming the oxidative microenvironment: Antioxidant nanoplatforms for central nervous system repair. — PubMed · 2026 · Journal Article
- Traumatic Spinal Cord Injury: A Contemporary Review of Classification, Evaluation, and Acute Management. — PubMed · 2026 · Journal Article
- NRN1 inhibits neuronal apoptosis and improves motor recovery after spinal cord injury via binding to FZD2 to activate the GSK-3β/Nrf2 pathway. — PubMed · 2026 · Journal Article
- Titer- and Intervention Timing-Dependent Functional Effects of AAV9-NeuroD1 Gene Therapy on Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Spinal cord stimulation: An emerging strategy for chronic pain relief after spinal cord injury. — PubMed · 2026 · Journal Article
- Safety, tolerability and preliminary efficacy of ALMB-0166 in patients with acute spine cord injury. — PubMed · 2026 · Journal Article
- Gut-derived signals regulating glial activation and secondary neuroinflammation after spinal cord injury: an evidence mapping and mechanistic framework. — PubMed · 2026 · Journal Article
- PLIN2-PGAM5-regulated lipid droplet-mitochondria contacts drive microglial neuroinflammation after spinal cord injury via fatty acid metabolic reprogramming. — PubMed · 2026 · Journal Article
- Targeting Interleukin-6 Signaling with Reactive-Oxygen-Species-Responsive Hydrogel to Promote Regeneration after Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Sex differences in patient mortality after traumatic spinal cord injury: A systematic review and meta-analysis. — PubMed · 2026 · Journal Article
- Peripheral SBK1 and ADGRG5 as Biomarkers of Cell Adhesion Molecule-Associated Immune Alterations after Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Safety and Efficacy of Therapeutic Hypothermia in Traumatic Spinal Cord Injury Management: A Systematic Review and MetaAnalysis. — PubMed · 2026 · Journal Article
- Semiautomated Volumetric Hemorrhage Quantification Using High-Frequency Ultrasound Following Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Research progress on the effects of epidural electrical stimulation on lower extremity function in patients with spinal cord injury. — PubMed · 2026 · Journal Article
- The effect of concurrent neural injuries on hemorrhage. — PubMed · 2026 · Journal Article
- Neuroprotective potential of the natural polyphenol Procyanidin B2 in spinal cord injury: a comprehensive study utilizing machine learning, network pharmacology, and in vivo validation. — PubMed · 2026 · Journal Article
- Frequency-Domain Analysis Links Autonomic Disruption to Renal Autoregulatory Failure after Spinal Cord Injury. — PubMed · 2026 · Journal Article
- The intravenous targeted nanopeptide, CAQK, is neuroprotective and improves motor function after spinal cord injury in rats. — PubMed · 2026 · Journal Article
- Cross-Species Transcriptomic Analysis Identifies an Endocannabinoid-Associated Immune Remodeling Signature and Candidate Pharmacologic Targets in Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Ultra-early decompression and prevention of secondary injury in traumatic spinal cord injury: A single-center study. — PubMed · 2026 · Journal Article
- Photobiomodulation Therapy for Traumatic Spinal Cord Injury: Current Evidence and Future Directions. — PubMed · 2026 · Journal Article
- Exercise-derived exosomal miR-151-3p: An innovative anti-inflammatory and antioxidant therapeutic for spinal cord injury. — PubMed · 2026 · Journal Article
- Mechanisms and Applications of Conductive Biomaterials in Spinal Cord Injury Repair. — PubMed · 2026 · Journal Article
- P2X7 receptor antagonism with Brilliant Blue G promotes functional recovery in spontaneous canine spinal cord injury: a preliminary study in a large animal model. — PubMed · 2026 · Journal Article
- Intravenously Delivered Lipid Nanoparticles Access Acute Spinal Cord Injury via Disrupted Vasculature. — PubMed · 2026 · Journal Article
- Neural stem cell-derived extracellular vesicles drive early neuroprotective and anti-apoptotic responses in spinal cord injury organotypic slices. — PubMed · 2026 · Journal Article
- Activin A enhances neurofunctional recovery following traumatic spinal cord injury by inhibiting autophagy. — PubMed · 2026 · Journal Article
- NG2 Glia and Cellular Crosstalk in Health and Disease: Focus on Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Spinal cord injury-derived exosomes exacerbate damage: miR-155-5p mediates inflammatory responses. — PubMed · 2026 · Journal Article
- Effects of GLP-1 Receptor Agonist Exenatide on Mitochondrial Dysfunction After Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Atractylenolide III for central nervous system disorders: a review of multi-target mechanisms and therapeutic potential. — PubMed · 2026 · Journal Article
- Sulforaphane enhances locomotor recovery after spinal cord injury through antioxidant, anti-inflammatory, and JAK/STAT-modulating mechanisms. — PubMed · 2026 · Journal Article
- How to Educate Learners to Manipulate Equipment in Trauma (HELMET): An Educational Workshop on Football Equipment Removal in Trauma Care. — PubMed · 2026 · Journal Article
- Neuroprotective effects of traditional Chinese medicine using zebrafish models - a review. — PubMed · 2026 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])