A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as laboratory work
- Engineered T cell therapy for central nervous system injury. — PubMed · 2024 · Journal Article
- Pathophysiology of Spinal Cord Injury and Tissue Engineering Approach for Its Neuronal Regeneration: Current Status and Future Prospects. — PubMed · 2023 · Review
- The Effect of Inflammatory Priming on the Therapeutic Potential of Mesenchymal Stromal Cells for Spinal Cord Repair. — PubMed · 2021 · Journal Article
- Recent Advances in the Regenerative Approaches for Traumatic Spinal Cord Injury: Materials Perspective. — PubMed · 2020 · Journal Article
- Docosahexaenoic Acid-Loaded Polylactic Acid Core-Shell Nanofiber Membranes for Regenerative Medicine after Spinal Cord Injury: In Vitro and In Vivo Study. — PubMed · 2020 · Journal Article
- Curcumin Protects against White Matter Injury through NF-κB and Nrf2 Cross Talk. — PubMed · 2020 · Journal Article
- Astrocyte-Encapsulated Hydrogel Microfibers Enhance Neuronal Circuit Generation. — PubMed · 2020 · Journal Article
- Inhibiting store-operated calcium entry attenuates white matter secondary degeneration following SCI. — PubMed · 2020 · Journal Article
- Modulation of extrasynaptic GABAergic receptor activity influences glutamate release and neuronal survival following excitotoxic damage to mouse spinal cord neurons. — PubMed · 2019 · Journal Article
- Pifithrin-μ modulates microglial activation and promotes histological recovery following spinal cord injury. — PubMed · 2019 · Journal Article
- Effects of dexamethasone on autophagy and apoptosis in acute spinal cord injury. — PubMed · 2018 · Journal Article
- Cetuximab and Taxol co-modified collagen scaffolds show combination effects for the repair of acute spinal cord injury. — PubMed · 2018 · Journal Article
- Perineurium-like sheath derived from long-term surviving mesenchymal stem cells confers nerve protection to the injured spinal cord. — PubMed · 2018 · Journal Article
- The neuroprotective effect of rat adipose tissue-derived mesenchymal stem cell-conditioned medium on cortical neurons using an in vitro model of SCI inflammation. — PubMed · 2018 · Journal Article
- Dl-3-n-butylphthalide attenuates acute inflammatory activation in rats with spinal cord injury by inhibiting microglial TLR4/NF-κB signalling. — PubMed · 2017 · Journal Article
- Effects of erythropoietin and methylprednisolone on AQP4 expression in astrocytes. — PubMed · 2017 · Journal Article
- Tissue-Engineered Regeneration of Hemisected Spinal Cord Using Human Endometrial Stem Cells, Poly ε-Caprolactone Scaffolds, and Crocin as a Neuroprotective Agent. — PubMed · 2017 · Journal Article
- ASIC channel inhibition enhances excitotoxic neuronal death in an in vitro model of spinal cord injury. — PubMed · 2017 · Journal Article
- Differential Neuroprotective Effects of Interleukin-1 Receptor Antagonist on Spinal Cord Neurons after Excitotoxic Injury. — PubMed · 2017 · Journal Article
- A study of cannabinoid-1 receptors during the early phase of excitotoxic damage to rat spinal locomotor networks in vitro. — PubMed · 2016 · Journal Article
- Bone marrow-derived mesenchymal stem cells in three-dimensional culture promote neuronal regeneration by neurotrophic protection and immunomodulation. — PubMed · 2016 · Journal Article
- Delayed application of the anesthetic propofol contrasts the neurotoxic effects of kainate on rat organotypic spinal slice cultures. — PubMed · 2016 · Journal Article
- Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury. — PubMed · 2015 · Journal Article
- PERK pathway is involved in oxygen-glucose-serum deprivation-induced NF-kB activation via ROS generation in spinal cord astrocytes. — PubMed · 2015 · Journal Article
- The volatile anesthetic methoxyflurane protects motoneurons against excitotoxicity in an in vitro model of rat spinal cord injury. — PubMed · 2015 · Journal Article
- Investigation of anti-oxidative stress in vitro and water apparent diffusion coefficient in MRI on rat after spinal cord injury in vivo with Tithonia diversifolia ethanolic extracts treatment. — PubMed · 2014 · Journal Article
- Interleukin-1 receptor antagonist promotes survival of ventral horn neurons and suppresses microglial activation in mouse spinal cord slice cultures. — PubMed · 2014 · Journal Article
- Effects of cerebrolysin on motor-neuron-like NSC-34 cells. — PubMed · 2014 · Journal Article
- S100β as an early biomarker of excitotoxic damage in spinal cord organotypic cultures. — PubMed · 2014 · Journal Article
- Omega-conotoxin MVIIC attenuates neuronal apoptosis in vitro and improves significant recovery after spinal cord injury in vivo in rats. — PubMed · 2014 · Journal Article
- Functional regeneration of intraspinal connections in a new in vitro model. — PubMed · 2014 · Journal Article
- Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury. — PubMed · 2013 · Journal Article
- Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis. — PubMed · 2013 · Journal Article
- Differential pattern of neuroprotection in lumbar, cervical and thoracic spinal cord segments in an organotypic rat model of glutamate-induced excitotoxicity. — PubMed · 2013 · Journal Article
- Neuroprotection by steroids after neurotrauma in organotypic spinal cord cultures: a key role for progesterone receptors and steroidal modulators of GABA(A) receptors. — PubMed · 2013 · Comparative Study
- A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury. — PubMed · 2013 · Journal Article
- Simulated microgravity facilitates cell migration and neuroprotection after bone marrow stromal cell transplantation in spinal cord injury. — PubMed · 2013 · Journal Article
- The C-terminal domain of tetanus toxin protects motoneurons against acute excitotoxic damage on spinal cord organotypic cultures. — PubMed · 2013 · Journal Article
- Microglial inhibitory factor (MIF/TKP) mitigates secondary damage following spinal cord injury. — PubMed · 2012 · Journal Article
- New therapeutic advances in CNS injury and repair. — PubMed · 2012 · Conference Proceedings
- Spinal cord clinical trials and the role for bioengineering. — PubMed · 2012 · Journal Article
- GW0742, a high-affinity PPAR-δ agonist, mediates protection in an organotypic model of spinal cord damage. — PubMed · 2012 · Journal Article
- Curcumin attenuates the expression and secretion of RANTES after spinal cord injury in vivo and lipopolysaccharide-induced astrocyte reactivation in vitro. — PubMed · 2011 · Journal Article
- Studies of locomotor network neuroprotection by the selective poly(ADP-ribose) polymerase-1 inhibitor PJ-34 against excitotoxic injury to the rat spinal cord in vitro. — PubMed · 2011 · Journal Article
- Efficacy of olfactory ensheathing cells to support regeneration after spinal cord injury is influenced by method of culture preparation. — PubMed · 2011 · Comparative Study
- Silymarin protects spinal cord and cortical cells against oxidative stress and lipopolysaccharide stimulation. — PubMed · 2010 · Journal Article
- Effects of C3 deficiency on inflammation and regeneration following spinal cord injury in mice. — PubMed · 2010 · Journal Article
- The effect of umbilical cord blood cells on outcomes after experimental traumatic spinal cord injury. — PubMed · 2010 · Journal Article
- Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. — PubMed · 2010 · Journal Article
- Kainate-induced delayed onset of excitotoxicity with functional loss unrelated to the extent of neuronal damage in the in vitro spinal cord. — PubMed · 2010 · Journal Article
- Chitosan produces potent neuroprotection and physiological recovery following traumatic spinal cord injury. — PubMed · 2010 · Journal Article
- Neuroprotection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro. — PubMed · 2010 · Journal Article
- Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter. — PubMed · 2010 · Journal Article
- Polyethylene glycol enhances axolemmal resealing following transection in cultured cells and in ex vivo spinal cord. — PubMed · 2010 · Journal Article
- Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury. — PubMed · 2009 · Journal Article
- Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons. — PubMed · 2009 · Journal Article
- Systemic polyethylene glycol promotes neurological recovery and tissue sparing in rats after cervical spinal cord injury. — PubMed · 2009 · Journal Article
- Axonal protective effects of the myelin-associated glycoprotein. — PubMed · 2009 · Journal Article
- Drug screening of neuroprotective agents on an organotypic-based model of spinal cord excitotoxic damage. — PubMed · 2009 · Journal Article
- Neuroprotective effects of erythropoietin posttreatment against kainate-induced excitotoxicity in mixed spinal cultures. — PubMed · 2009 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])