A subject this map covers
Scar proteoglycan modulation
Part of: Glial scar and its remodelling
What belongs here
Acting on the scar’s inhibitory molecules or their receptors without enzymatic digestion.
What does not belong here, however close it looks
Enzymatic digestion is chondroitinase, a separate concept.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 84 records · 2000–2025
- Indexed as work in animals: 244 records · 1997–2026
- Indexed as laboratory work: 23 records · 2004–2021
- The source has not said who or what was studied: 68 records · 1977–2026
- No clinical trial on this subject is registered for spinal cord injury.
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
419 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Curcumin improves neural function after spinal cord injury by the joint inhibition of the intracellular and extracellular components of glial scar. — PubMed · 2015 · Journal Article
- Antisense vimentin cDNA combined with chondroitinase ABC promotes axon regeneration and functional recovery following spinal cord injury in rats. — PubMed · 2015 · Journal Article
- Integrity of cortical perineuronal nets influences corticospinal tract plasticity after spinal cord injury. — PubMed · 2015 · Journal Article
- Axonal regeneration through the fibrous scar in lesioned goldfish spinal cord. — PubMed · 2015 · Journal Article
- Hyaluronan tetrasaccharide exerts neuroprotective effect and promotes functional recovery after acute spinal cord injury in rats. — PubMed · 2015 · Journal Article
- Permissive Schwann cell graft/spinal cord interfaces for axon regeneration. — PubMed · 2015 · Journal Article
- Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury. — PubMed · 2015 · Journal Article
- Transforming growth factor β-induced expression of chondroitin sulfate proteoglycans is mediated through non-Smad signaling pathways. — PubMed · 2015 · Journal Article
- Entrapment via synaptic-like connections between NG2 proteoglycan+ cells and dystrophic axons in the lesion plays a role in regeneration failure after spinal cord injury. — PubMed · 2014 · Journal Article
- Effects of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on glial scar formation after spinal cord injury in rats. — PubMed · 2014 · Journal Article
- Independent evaluation of the anatomical and behavioral effects of Taxol in rat models of spinal cord injury. — PubMed · 2014 · Journal Article
- Olfactory ensheathing cells (OECs) degrade neurocan in injured spinal cord by secreting matrix metalloproteinase-2 in a rat contusion model. — PubMed · 2014 · Journal Article
- Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury. — PubMed · 2014 · Journal Article
- Neural precursor cell transplantation enhances functional recovery and reduces astrogliosis in bilateral compressive/contusive cervical spinal cord injury. — PubMed · 2014 · Journal Article
- Assessment of Nogo-66 receptor 1 function in vivo after spinal cord injury. — PubMed · 2014 · Journal Article
- tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury. — PubMed · 2014 · Journal Article
- Changes in NG2 cells and oligodendrocytes in a new model of intraspinal hemorrhage. — PubMed · 2014 · Journal Article
- Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury. — PubMed · 2014 · Journal Article
- Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration. — PubMed · 2014 · Journal Article
- Spinal cord regeneration. — PubMed · 2014 · Journal Article
- Comparison of sensory neuron growth cone and filopodial responses to structurally diverse aggrecan variants, in vitro. — PubMed · 2013 · Journal Article
- Perivascular fibroblasts form the fibrotic scar after contusive spinal cord injury. — PubMed · 2013 · Journal Article
- Host reaction to poly(2-hydroxyethyl methacrylate) scaffolds in a small spinal cord injury model. — PubMed · 2013 · Journal Article
- [Effects of chondroitinase ABC combined with bone marrow mesenchymal stem cells transplantation on repair of spinal cord injury in rats]. — PubMed · 2013 · English Abstract
- Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats. — PubMed · 2013 · Journal Article
- SOX2 expression is upregulated in adult spinal cord after contusion injury in both oligodendrocyte lineage and ependymal cells. — PubMed · 2013 · Journal Article
- Plastic changes in lumbar segments after thoracic spinal cord injuries in adult rats: an integrative view of spinal nociceptive dysfunctions. — PubMed · 2013 · Journal Article
- Transplantation of D15A-expressing glial-restricted-precursor-derived astrocytes improves anatomical and locomotor recovery after spinal cord injury. — PubMed · 2013 · Journal Article
- Invasion of lesion territory by regenerating fibers after spinal cord injury in adult macaque monkeys. — PubMed · 2012 · Journal Article
- Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice. — PubMed · 2012 · Journal Article
- Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord. — PubMed · 2012 · Journal Article
- p38 mitogen-activated protein kinase inhibitor reduces neurocan production in cultured spinal cord astrocytes. — PubMed · 2012 · Journal Article
- Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticity. — PubMed · 2012 · Journal Article
- Ferritin stimulates oligodendrocyte genesis in the adult spinal cord and can be transferred from macrophages to NG2 cells in vivo. — PubMed · 2012 · Journal Article
- Immunohistochemical study of arginase-1 in the spinal cords of rats with clip compression injury. — PubMed · 2012 · Journal Article
- The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. — PubMed · 2012 · Journal Article
- Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. — PubMed · 2012 · Journal Article
- Effects of andrographolide and 14-deoxy-11,12-didehydroandrographolide on cultured primary astrocytes and PC12 cells. — PubMed · 2012 · Journal Article
- Induction of angiopoietin-2 after spinal cord injury. — PubMed · 2012 · Journal Article
- Axon-glia synapses are highly vulnerable to white matter injury in the developing brain. — PubMed · 2012 · Journal Article
- Imatinib enhances functional outcome after spinal cord injury. — PubMed · 2012 · Journal Article
- Promotion of spinal cord regeneration by neural stem cell-secreted trimerized cell adhesion molecule L1. — PubMed · 2012 · Journal Article
- Chondroitinase ABC combined with neurotrophin NT-3 secretion and NR2D expression promotes axonal plasticity and functional recovery in rats with lateral hemisection of the spinal cord. — PubMed · 2011 · Journal Article
- IT delivery of ChABC modulates NG2 and promotes GAP-43 axonal regrowth after spinal cord injury. — PubMed · 2011 · Journal Article
- Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. — PubMed · 2011 · Journal Article
- Matrix metalloproteinase-9 controls proliferation of NG2+ progenitor cells immediately after spinal cord injury. — PubMed · 2011 · Journal Article
- Regulation of chondroitin sulphate proteoglycan and reactive gliosis after spinal cord transection: effects of peripheral nerve graft and fibroblast growth factor 1. — PubMed · 2011 · Journal Article
- The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes. — PubMed · 2011 · Journal Article
- Alterations in recovery from spinal cord injury in rats treated with recombinant human bone morphogenetic protein-2 for posterolateral arthrodesis. — PubMed · 2011 · Journal Article
- High molecular weight hyaluronic acid limits astrocyte activation and scar formation after spinal cord injury. — PubMed · 2011 · Journal Article
- Functional regeneration of respiratory pathways after spinal cord injury. — PubMed · 2011 · Journal Article
- Decorin, erythroblastic leukaemia viral oncogene homologue B4 and signal transducer and activator of transcription 3 regulation of semaphorin 3A in central nervous system scar tissue. — PubMed · 2011 · Journal Article
- Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. — PubMed · 2011 · Journal Article
- The fate of proliferating cells in the injured adult spinal cord. — PubMed · 2011 · Editorial
- Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. — PubMed · 2011 · Journal Article
- Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts. — PubMed · 2011 · Journal Article
- Bone marrow mesenchymal stem cells and electroacupuncture downregulate the inhibitor molecules and promote the axonal regeneration in the transected spinal cord of rats. — PubMed · 2011 · Journal Article
- The glial scar-monocyte interplay: a pivotal resolution phase in spinal cord repair. — PubMed · 2011 · Journal Article
- Chondroitinase ABC enhances pericontusion axonal sprouting but does not confer robust improvements in behavioral recovery. — PubMed · 2010 · Journal Article
- Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord. — PubMed · 2010 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-10-05 | the source found 0 · this programme has 0 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 1527414 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 | the source found 404 · this programme has 404 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("chondroitin sulfate proteoglycan" OR "CSPG receptor" OR "PTPsigma peptide") - Crossref
spinal cord injury chondroitin sulfate proteoglycan CSPG receptor - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Chondroitin Sulfate Proteoglycans"[MeSH Terms] OR "chondroitin sulfate proteoglycan"[Title/Abstract] OR "CSPG receptor"[Title/Abstract] OR "PTPsigma peptide"[Title/Abstract])