A subject this map covers
Gene therapy
What belongs here
Introducing, silencing or editing a gene in nervous-system cells after injury.
What does not belong here, however close it looks
Cells engineered in a dish and then transplanted also belong to cell therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 185 records · 1992–2026
- Indexed as work in animals: 221 records · 1994–2026
- Indexed as laboratory work: 18 records · 1997–2021
- The source has not said who or what was studied: 99 records · 1997–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
523 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Registered or indexed as work in people
- Gene therapy for central nervous system injury: the use of cationic liposomes: an invited review. — PubMed · 1997 · Journal Article
- Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat. — PubMed · 1996 · Journal Article
- [Treatment of the future for spinal cord injuries]. — PubMed · 1995 · English Abstract
- Ex vivo gene therapy for Alzheimer's disease and spinal cord injury. — PubMed · 1995 · Journal Article
- Spinal cord injuries. New optimism blooms for developing treatments. — PubMed · 1992 · News
Indexed as work in animals
- Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury. — PubMed · 2026 · Journal Article
- Transneuronal cytokine delivery promotes functional recovery across spinal cord contusion severities via descending circuit plasticity. — PubMed · 2026 · Journal Article
- Dual-targeting nanoparticles enhance microglial P2Y12R expression to promote neuronal mitophagy for repairing spinal cord injury. — PubMed · 2026 · Journal Article
- NanoScript-Enabled Nonviral Transient Repression of Phosphatase and Tensin Homolog for Axonal Regeneration and Central Nervous System Injury Repair. — PubMed · 2026 · Journal Article
- Sirtuin1 modulates P53/Nrf2 pathway to promote spinal cord injury repair. — PubMed · 2026 · Journal Article
- A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury. — PubMed · 2026 · Journal Article
- The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS. — PubMed · 2026 · Journal Article
- Disrupting CSPG-Driven Microglia-Astrocyte Crosstalk Enables Scar-Free Repair in Spinal Cord Injury. — PubMed · 2026 · Journal Article
- AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury. — PubMed · 2025 · Journal Article
- TREM2 Impedes Recovery After Spinal Cord Injury by Regulating Microglial Lysosomal Membrane Permeabilization-Mediated Autophagy. — PubMed · 2025 · Journal Article
- Netrin-3 enhances recovery and reduces inflammation following spinal cord injury via suppressing NLRP1 inflammasome activation. — PubMed · 2025 · Journal Article
- Fidgetin-like 2 knockdown increases acute neuroinflammation and improves recovery in a rat model of spinal cord injury. — PubMed · 2025 · Journal Article
- Nonresolving Neuroinflammation Regulates Axon Regeneration in Chronic Spinal Cord Injury. — PubMed · 2025 · Journal Article
- AAV6 mediated Gsx1 expression in neural stem progenitor cells promotes neurogenesis and restores locomotor function after contusion spinal cord injury. — PubMed · 2024 · Journal Article
- Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica. — PubMed · 2024 · Journal Article
- Knockdown of calpain1 in lumbar motoneurons reduces spasticity after spinal cord injury in adult rats. — PubMed · 2024 · Journal Article
- Injectable and Photocurable Gene Scaffold Facilitates Efficient Repair of Spinal Cord Injury. — PubMed · 2024 · Journal Article
- Artificially reprogrammed stem cells deliver transcytosable nanocomplexes for improved spinal cord repair. — PubMed · 2023 · Journal Article
- Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury. — PubMed · 2023 · Journal Article
- Targeting reactive astrocytes by pH-responsive ligand-bonded polymeric nanoparticles in spinal cord injury. — PubMed · 2023 · Journal Article
- AAV Vector Mediated Delivery of NG2 Function Neutralizing Antibody and Neurotrophin NT-3 Improves Synaptic Transmission, Locomotion, and Urinary Tract Function after Spinal Cord Contusion Injury in Adult Rats. — PubMed · 2023 · Journal Article
- Up-Regulation of Astrocytic Fgfr4 Expression in Adult Mice after Spinal Cord Injury. — PubMed · 2023 · Journal Article
- A Localized Materials-Based Strategy to Non-Virally Deliver Chondroitinase ABC mRNA Improves Hindlimb Function in a Rat Spinal Cord Injury Model. — PubMed · 2022 · Journal Article
- Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters. — PubMed · 2022 · Journal Article
- Application of a New Gene-Cell Construct Based on the Olfactory Mucosa Escheating Cells Transduced with an Adenoviral Vector Encoding Mature BDNF in the Therapy of Spinal Cord Cysts. — PubMed · 2022 · Journal Article
- New Therapy for Spinal Cord Injury: Autologous Genetically-Enriched Leucoconcentrate Integrated with Epidural Electrical Stimulation. — PubMed · 2022 · Journal Article
- IGF1 Gene Therapy Reversed Cognitive Deficits and Restored Hippocampal Alterations After Chronic Spinal Cord Injury. — PubMed · 2021 · Journal Article
- MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3). — PubMed · 2021 · Journal Article
- Lentiviral Vectors Delivered with Biomaterials as Therapeutics for Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Gsx1 promotes locomotor functional recovery after spinal cord injury. — PubMed · 2021 · Journal Article
- A 3D Fiber-Hydrogel Based Non-Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Assessment of the Oral Delivery of a Myelin Basic Protein Gene Promoter with Antiapoptotic bcl-x(L) (pMBP-bcl-x(L)) DNA by Cyclic Peptide Nanotubes with Two Aspect Ratios and Its Biodistribution in the Brain and Spinal Cord. — PubMed · 2021 · Journal Article
- IL-10 lentivirus-laden hydrogel tubes increase spinal progenitor survival and neuronal differentiation after spinal cord injury. — PubMed · 2021 · Journal Article
- SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats. — PubMed · 2021 · Journal Article
- Combining task-based rehabilitative training with PTEN inhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice. — PubMed · 2021 · Journal Article
- Promotion of corticospinal tract growth by KLF6 requires an injury stimulus and occurs within four weeks of treatment. — PubMed · 2021 · Journal Article
- AAV2-mediated and hypoxia response element-directed expression of bFGF in neural stem cells showed therapeutic effects on spinal cord injury in rats. — PubMed · 2021 · Journal Article
- Lentiviral Interleukin-10 Gene Therapy Preserves Fine Motor Circuitry and Function After a Cervical Spinal Cord Injury in Male and Female Mice. — PubMed · 2021 · Journal Article
- Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model. — PubMed · 2020 · Journal Article
- Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury. — PubMed · 2020 · Journal Article
- Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries. — PubMed · 2020 · Journal Article
- Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. — PubMed · 2020 · Journal Article
- Astrocyte-selective AAV-ADAMTS4 gene therapy combined with hindlimb rehabilitation promotes functional recovery after spinal cord injury. — PubMed · 2020 · Journal Article
- Profilin 1 delivery tunes cytoskeletal dynamics toward CNS axon regeneration. — PubMed · 2020 · Journal Article
- Knockdown of macrophage migration inhibitory factor (MIF), a novel target to protect neurons from parthanatos induced by simulated post-spinal cord injury oxidative stress. — PubMed · 2020 · Journal Article
- Adeno-associated virus packaged TRPC5 gene therapy alleviated spinal cord ischemic reperfusion injury in rats. — PubMed · 2020 · Journal Article
- Adenovirus vector‑mediated in vivo gene transfer of nuclear factor erythroid‑2p45‑related factor 2 promotes functional recovery following spinal cord contusion. — PubMed · 2019 · Journal Article
- Prospects of siRNA cocktails as tools for modifying multiple gene targets in the injured spinal cord. — PubMed · 2019 · Journal Article
- FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK. — PubMed · 2019 · Journal Article
- Intramuscular Injection of Adenoassociated Virus Encoding Human Neurotrophic Factor 3 and Exercise Intervention Contribute to Reduce Spasms after Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Combinatorial lentiviral gene delivery of pro-oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury. — PubMed · 2019 · Journal Article
- Inhibition of EphA/Ephrin-A signaling using genetic and pharmacologic approaches improves recovery following traumatic brain injury in mice. — PubMed · 2019 · Journal Article
- Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury. — PubMed · 2018 · Journal Article
- Cortical AAV-CNTF Gene Therapy Combined with Intraspinal Mesenchymal Precursor Cell Transplantation Promotes Functional and Morphological Outcomes after Spinal Cord Injury in Adult Rats. — PubMed · 2018 · Journal Article
- Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury. — PubMed · 2018 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 3660371 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 1 · this programme has 495 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("gene therapy" OR "gene delivery") - Crossref
spinal cord injury gene therapy gene delivery - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Genetic Therapy"[MeSH Terms] OR "gene therapy"[Title/Abstract] OR "gene delivery"[Title/Abstract])