A subject this map covers
Gene therapy
What belongs here
Introducing, silencing or editing a gene in nervous-system cells after injury.
What does not belong here, however close it looks
Cells engineered in a dish and then transplanted also belong to cell therapy.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 185 records · 1992–2026
- Indexed as work in animals: 221 records · 1994–2026
- Indexed as laboratory work: 18 records · 1997–2021
- The source has not said who or what was studied: 99 records · 1997–2026
- Nobody has yet checked any of this against its original for this map, so none of it is on the checked shelf.
Checked
Records a person has read against the original and published into this map. These carry measurements, evidence states and a place on the ladder.
Nobody has checked a record on this subject yet.
Checking is done by a person, one record at a time, and this subject has not reached the queue yet. The shelf below is what the sources hold in the meantime; it has not been read by anybody.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
523 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Knockdown of MicroRNA-21 Promotes Neurological Recovery After Acute Spinal Cord Injury. — PubMed · 2018 · Journal Article
- MicroRNA‑381/Hes1 is a potential therapeutic target for spinal cord injury. — PubMed · 2018 · Journal Article
- Retrogradely Transportable Lentivirus Tracers for Mapping Spinal Cord Locomotor Circuits. — PubMed · 2018 · Journal Article
- Microfiber drug/gene delivery platform for study of myelination. — PubMed · 2018 · Journal Article
- Lentiviral vector delivery of short hairpin RNA to NgR1 promotes nerve regeneration and locomotor recovery in injured rat spinal cord. — PubMed · 2018 · Journal Article
- Noninvasive, targeted gene therapy for acute spinal cord injury using LIFU-mediated BDNF-loaded cationic nanobubble destruction. — PubMed · 2018 · Journal Article
- Lentivirus-mediated silencing of the CTGF gene suppresses the formation of glial scar tissue in a rat model of spinal cord injury. — PubMed · 2018 · Journal Article
- Morphological changes in different populations of bladder afferent neurons detected by herpes simplex virus (HSV) vectors with cell-type-specific promoters in mice with spinal cord injury. — PubMed · 2017 · Journal Article
- Improved stem cell therapy of spinal cord injury using GDNF-overexpressed bone marrow stem cells in a rat model. — PubMed · 2017 · Journal Article
- Physicochemical stability and transfection efficiency of cationic amphiphilic copolymer/pDNA polyplexes for spinal cord injury repair. — PubMed · 2017 · Journal Article
- Lentivirus-mediated inhibition of AQP4 accelerates motor function recovery associated with NGF in spinal cord contusion rats. — PubMed · 2017 · Journal Article
- Lentivirus-mediated microRNA-124 gene-modified bone marrow mesenchymal stem cell transplantation promotes the repair of spinal cord injury in rats. — PubMed · 2017 · Journal Article
- Effect of urethral wall injection of replication-defective herpes simplex virus-mediated gene transfer of kynurenine aminotransferase on urethral pressure in spinal cord-injured rats. — PubMed · 2017 · Evaluation Study
- Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice. — PubMed · 2017 · Journal Article
- Nerve growth factor delivery by ultrasound-mediated nanobubble destruction as a treatment for acute spinal cord injury in rats. — PubMed · 2017 · Journal Article
- RhoA knockdown by cationic amphiphilic copolymer/siRhoA polyplexes enhances axonal regeneration in rat spinal cord injury model. — PubMed · 2017 · Journal Article
- Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment. — PubMed · 2017 · Journal Article
- Targeting Motor End Plates for Delivery of Adenoviruses: An Approach to Maximize Uptake and Transduction of Spinal Cord Motor Neurons. — PubMed · 2016 · Journal Article
- Production of high quality brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) RNA from isolated populations of rat spinal cord motor neurons obtained by Laser Capture Microdissection (LCM). — PubMed · 2016 · Journal Article
- Lentivirus-mediated PGC-1α overexpression protects against traumatic spinal cord injury in rats. — PubMed · 2016 · Journal Article
- Adeno associated viral-mediated intraosseous labeling of bone marrow derived cells for CNS tracking. — PubMed · 2016 · Journal Article
- Cationic, amphiphilic copolymer micelles as nucleic acid carriers for enhanced transfection in rat spinal cord. — PubMed · 2016 · Journal Article
- Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury. — PubMed · 2016 · Journal Article
- Gene-activated fat grafts for the repair of spinal cord injury: a pilot study. — PubMed · 2016 · Journal Article
- TrkB gene therapy by adeno-associated virus enhances recovery after cervical spinal cord injury. — PubMed · 2016 · Journal Article
- Releasing of Herpes Simplex Virus Carrying NGF in Subarachnoid Space Promotes the Functional Repair in Spinal Cord Injured Rats. — PubMed · 2016 · Journal Article
- Antiapoptotic Effect of Highly Secreted GMCSF From Neuronal Cell-specific GMCSF Overexpressing Neural Stem Cells in Spinal Cord Injury Model. — PubMed · 2015 · Journal Article
- Myeloid-Specific Blockade of Notch Signaling by RBP-J Knockout Attenuates Spinal Cord Injury Accompanied by Compromised Inflammation Response in Mice. — PubMed · 2015 · Journal Article
- Neuroprotective effect of functionalized multi-walled carbon nanotubes on spinal cord injury in rats. — PubMed · 2015 · Journal Article
- Multifunctional nanoparticles for gene delivery and spinal cord injury. — PubMed · 2015 · Journal Article
- Segmental distribution of the motor neuron columns that supply the rat hindlimb: A muscle/motor neuron tract-tracing analysis targeting the motor end plates. — PubMed · 2015 · Journal Article
- Chondroitinase gene therapy improves upper limb function following cervical contusion injury. — PubMed · 2015 · Journal Article
- Local Injection of Lenti-BDNF at the Lesion Site Promotes M2 Macrophage Polarization and Inhibits Inflammatory Response After Spinal Cord Injury in Mice. — PubMed · 2015 · Journal Article
- AAV-mediated expression of BAG1 and ROCK2-shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury. — PubMed · 2015 · Journal Article
- Gene delivery to the spinal cord using MRI-guided focused ultrasound. — PubMed · 2015 · Journal Article
- MASH1/Ascl1a leads to GAP43 expression and axon regeneration in the adult CNS. — PubMed · 2015 · Journal Article
- Overexpression of Sox11 promotes corticospinal tract regeneration after spinal injury while interfering with functional recovery. — PubMed · 2015 · Journal Article
- Prohibitin 1 gene delivery promotes functional recovery in rats with spinal cord injury. — PubMed · 2015 · Journal Article
- Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury. — PubMed · 2015 · Journal Article
- Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury. — PubMed · 2014 · Journal Article
- Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. — PubMed · 2014 · Journal Article
- Bone marrow-derived mesenchymal stem cells expressing the Shh transgene promotes functional recovery after spinal cord injury in rats. — PubMed · 2014 · Journal Article
- Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury. — PubMed · 2014 · Journal Article
- Overexpressing neuroglobin improves functional recovery by inhibiting neuronal apoptosis after spinal cord injury. — PubMed · 2014 · Journal Article
- Herpes simplex virus vector-mediated gene transfer of kynurenine aminotransferase improves detrusor overactivity in spinal cord-injured rats. — PubMed · 2014 · Journal Article
- Sox11 promotes endogenous neurogenesis and locomotor recovery in mice spinal cord injury. — PubMed · 2014 · Journal Article
- Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury. — PubMed · 2014 · Journal Article
- Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice. — PubMed · 2014 · Journal Article
- Does Nrf2 gene transfer facilitate recovery after contusion spinal cord injury? — PubMed · 2014 · Journal Article
- Effectiveness of intracavernous delivery of adenovirus encoding Smad7 gene on erectile function in a mouse model of cavernous nerve injury. — PubMed · 2014 · Journal Article
- Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene. — PubMed · 2013 · Journal Article
- Influences of HIF-lα on Bax/Bcl-2 and VEGF expressions in rats with spinal cord injury. — PubMed · 2013 · Journal Article
- Combination of chondroitinase ABC and AAV-NT3 promotes neural plasticity at descending spinal pathways after thoracic contusion in rats. — PubMed · 2013 · Journal Article
- Lentiviral mediated expression of a NGF-soluble Nogo receptor 1 fusion protein promotes axonal regeneration. — PubMed · 2013 · Journal Article
- Local injection of lentivirus encoding LINGO-1-shRNA promotes functional recovery in rats with complete spinal cord transection. — PubMed · 2013 · Journal Article
- Effect of neuroglobin genetically modified bone marrow mesenchymal stem cells transplantation on spinal cord injury in rabbits. — PubMed · 2013 · Journal Article
- The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127. — PubMed · 2013 · Journal Article
- The retrograde delivery of adenovirus vector carrying the gene for brain-derived neurotrophic factor protects neurons and oligodendrocytes from apoptosis in the chronically compressed spinal cord of twy/twy mice. — PubMed · 2012 · Journal Article
- Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord. — PubMed · 2012 · Journal Article
- Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways. — PubMed · 2012 · Journal Article
Where this was looked for, and when
The exact question each source was asked, the day it was asked, and what came back. A zero on this page is only honest if these are on it.
| ClinicalTrials.gov | asked, and it has nothing | asked on 2026-09-29 | the source found 0 · this programme has 2 · still to fetch 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 | the source found 3660371 · this programme has 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-10-12 | the source found 1 · this programme has 495 · still to fetch 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("gene therapy" OR "gene delivery") - Crossref
spinal cord injury gene therapy gene delivery - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Genetic Therapy"[MeSH Terms] OR "gene therapy"[Title/Abstract] OR "gene delivery"[Title/Abstract])