A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Neutrophil, Extracellular Matrix Components, and Their Interlinked Action in Promoting Secondary Pathogenesis After Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Overexpression of bone morphogenetic protein 7 reduces oligodendrocytes loss and promotes functional recovery after spinal cord injury. — PubMed · 2021 · Journal Article
- The neuroprotective role of morroniside against spinal cord injury in female rats. — PubMed · 2021 · Journal Article
- The protective effect and mechanism of COA-Cl in acute phase after spinal cord injury. — PubMed · 2021 · Journal Article
- Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats. — PubMed · 2021 · Journal Article
- Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Sigma 1 receptor agonist cutamesine promotes plasticity of serotonergic boutons in lumbar enlargement in spinal cord injured rats. — PubMed · 2021 · Journal Article
- BAPTA, a calcium chelator, neuroprotects injured neurons in vitro and promotes motor recovery after spinal cord transection in vivo. — PubMed · 2021 · Journal Article
- Gramine promotes functional recovery after spinal cord injury via ameliorating microglia activation. — PubMed · 2021 · Journal Article
- Nerve growth factor loaded macrophage-derived nanovesicles for inhibiting neuronal apoptosis after spinal cord injury. — PubMed · 2021 · Journal Article
- The Application of an Omentum Graft or Flap in Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Effect of humic acid on oxidative stress and neuroprotection in traumatic spinal cord injury: an experimental study. — PubMed · 2021 · Journal Article
- TAT-modified tetramethylpyrazine-loaded nanoparticles for targeted treatment of spinal cord injury. — PubMed · 2021 · Journal Article
- Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy. — PubMed · 2021 · Journal Article
- Neuroprotective effect of neuregulin-1β on spinal cord ischemia reperfusion injury. — PubMed · 2021 · Journal Article
- The Protein Kinase Inhibitor Midostaurin Improves Functional Neurological Recovery and Attenuates Inflammatory Changes Following Traumatic Cervical Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice. — PubMed · 2021 · Journal Article
- Mass Spectrometric Enzyme Histochemistry for Choline Acetyltransferase Reveals De Novo Acetylcholine Synthesis in Rodent Brain and Spinal Cord. — PubMed · 2021 · Journal Article
- Effects of Ganoderma lucidum Polysaccharides on Different Pathways Involved in the Development of Spinal Cord Ischemia Reperfusion Injury: Biochemical, Histopathologic, and Ultrastructural Analysis in a Rat Model. — PubMed · 2021 · Journal Article
- Sonic Hedgehog modulates the inflammatory response and improves functional recovery after spinal cord injury in a thoracic contusion-compression model. — PubMed · 2021 · Journal Article
- MicroRNA-145-Mediated KDM6A Downregulation Enhances Neural Repair after Spinal Cord Injury via the NOTCH2/Abcb1a Axis. — PubMed · 2021 · Journal Article
- Programmed death protein 1 is essential for maintaining the anti-inflammatory function of infiltrating regulatory T cells in a murine spinal cord injury model. — PubMed · 2021 · Journal Article
- Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5. — PubMed · 2021 · Journal Article
- Inhibition of Cytosolic Phospholipase A(2) Has Neuroprotective Effects on Motoneuron and Muscle Atrophy after Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Novel circular RNA 2960 contributes to secondary damage of spinal cord injury by sponging miRNA-124. — PubMed · 2021 · Journal Article
- Grape seed proanthocyanidins protect PC12 cells from hydrogen peroxide-induced damage via the PI3K/AKT signaling pathway. — PubMed · 2021 · Journal Article
- Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery. — PubMed · 2021 · Journal Article
- CCP1, a Tubulin Deglutamylase, Increases Survival of Rodent Spinal Cord Neurons following Glutamate-Induced Excitotoxicity. — PubMed · 2021 · Journal Article
- Therapeutics effects of [Pyr1] apelin-13 on rat contusion model of spinal cord injury: An experimental study. — PubMed · 2021 · Journal Article
- Verbascoside Attenuates Acute Inflammatory Injury Caused by an Intracerebral Hemorrhage Through the Suppression of NLRP3. — PubMed · 2021 · Journal Article
- Zinc provides neuroprotection by regulating NLRP3 inflammasome through autophagy and ubiquitination in a spinal contusion injury model. — PubMed · 2021 · Journal Article
- Peripheral Macrophage-derived Exosomes promote repair after Spinal Cord Injury by inducing Local Anti-inflammatory type Microglial Polarization via Increasing Autophagy. — PubMed · 2021 · Journal Article
- Acute Dose-Dependent Neuroprotective Effects of Poly(pro-17β-estradiol) in a Mouse Model of Spinal Contusion Injury. — PubMed · 2021 · Journal Article
- Transplantation of olfactory ensheathing cells promotes the therapeutic effect of neural stem cells on spinal cord injury by inhibiting necrioptosis. — PubMed · 2021 · Journal Article
- Neuroprotective potential of fisetin in an experimental model of spinal cord injury: via modulation of NF-κB/IκBα pathway. — PubMed · 2021 · Journal Article
- Controlled release of baricitinib from a thermos-responsive hydrogel system inhibits inflammation by suppressing JAK2/STAT3 pathway in acute spinal cord injury. — PubMed · 2021 · Journal Article
- Ginsenoside Rb1 attenuates microglia activation to improve spinal cord injury via microRNA-130b-5p/TLR4/NF-κB axis. — PubMed · 2021 · Journal Article
- Luteolin Modulates the NF-E2-Related Factor 2/Glutamate-Cysteine Ligase Pathway in Rats with Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Mitochondria exert age-divergent effects on recovery from spinal cord injury. — PubMed · 2021 · Journal Article
- Neuroprotective Effects of Milrinone on Experimental Acute Spinal Cord Injury: Rat Model. — PubMed · 2021 · Journal Article
- Regulation of Prdx6 by Nrf2 Mediated Through aiPLA2 in White Matter Reperfusion Injury. — PubMed · 2021 · Journal Article
- AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo. — PubMed · 2021 · Journal Article
- Acute Neural and Proteostasis Messenger Ribonucleic Acid Levels Predict Chronic Locomotor Recovery after Contusive Spinal Cord Injury. — PubMed · 2021 · Journal Article
- Autophagy Induction Contributes to the Neuroprotective Impact of Intermittent Fasting on the Acutely Injured Spinal Cord. — PubMed · 2021 · Journal Article
- Effects of Edaravone on Functional Recovery of a Rat Model with Spinal Cord Injury Through Induced Differentiation of Bone Marrow Mesenchymal Stem Cells into Neuron-Like Cells. — PubMed · 2021 · Journal Article
- Ketone Metabolite β-Hydroxybutyrate Ameliorates Inflammation After Spinal Cord Injury by Inhibiting the NLRP3 Inflammasome. — PubMed · 2021 · Journal Article
- Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model. — PubMed · 2021 · Journal Article
- Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats. — PubMed · 2021 · Journal Article
- Rea regulates microglial polarization and attenuates neuronal apoptosis via inhibition of the NF-κB and MAPK signalings for spinal cord injury repair. — PubMed · 2021 · Journal Article
- Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix. — PubMed · 2021 · Journal Article
- A combinatorial approach to modulate microenvironment toward regeneration and repair after spinal cord injury in rats. — PubMed · 2021 · Journal Article
- Azathioprine as a Neuroprotective Agent in Experimental Traumatic Spinal Cord Injury. — PubMed · 2021 · Journal Article
- CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling. — PubMed · 2021 · Journal Article
- Delayed administration of high dose human immunoglobulin G enhances recovery after traumatic cervical spinal cord injury by modulation of neuroinflammation and protection of the blood spinal cord barrier. — PubMed · 2021 · Journal Article
- Dexmedetomidine Reduces the Lidocaine-Induced Neurotoxicity by Inhibiting Inflammasome Activation and Reducing Pyroptosis in Rats. — PubMed · 2021 · Journal Article
- Exploring the potential of RhoA inhibitors to improve exercise-recoverable spinal cord injury: A systematic review and meta-analysis. — PubMed · 2021 · Journal Article
- Extracellular and nuclear roles of IL-37 after spinal cord injury. — PubMed · 2021 · Journal Article
- Hydrogen Sulfide Improves Functional Recovery in Rat Traumatic Spinal Cord Injury Model by Inducing Nuclear Translocation of NF-E2-Related Factor 2. — PubMed · 2021 · Journal Article
- Imaging of Neurotrauma in Acute and Chronic Settings. — PubMed · 2021 · Journal Article
- Neurologic and Histologic Tests Used to Measure Neuroprotective Effectiveness of Virus-Derived Immune-Modulating Proteins. — PubMed · 2021 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])