A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Stress Pathway Modulation Is Detrimental or Ineffective for Functional Recovery after Spinal Cord Injury in Mice. — PubMed · 2020 · Journal Article
- Enhanced Neural Regeneration with a Concomitant Treatment of Framework Nucleic Acid and Stem Cells in Spinal Cord Injury. — PubMed · 2020 · Journal Article
- Nanoparticles with antioxidant enzymes protect injured spinal cord from neuronal cell apoptosis by attenuating mitochondrial dysfunction. — PubMed · 2020 · Journal Article
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and "cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats. — PubMed · 2020 · Journal Article
- Cerebrolysin enhances spinal cord conduction and reduces blood-spinal cord barrier breakdown, edema formation, immediate early gene expression and cord pathology after injury. — PubMed · 2020 · Journal Article
- Dual regulation of microglia and neurons by Astragaloside IV-mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury. — PubMed · 2020 · Journal Article
- Investigation of Neuroprotective and Therapeutic Effects of Hesperidin in Experimental Spinal Cord Injury. — PubMed · 2020 · Journal Article
- Low-level laser therapy 810-nm up-regulates macrophage secretion of neurotrophic factors via PKA-CREB and promotes neuronal axon regeneration in vitro. — PubMed · 2020 · Journal Article
- MiRNA-125a-5p attenuates blood-spinal cord barrier permeability under hypoxia in vitro. — PubMed · 2020 · Journal Article
- N-methyl-D-aspartate Receptor Antagonists may Ameliorate Spinal Cord Injury by Inhibiting Oxidative Stress: An Experimental Study in Rats. — PubMed · 2020 · Journal Article
- Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis. — PubMed · 2020 · Journal Article
- Scopoletin Activates Adenosine Monophosphate-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling Pathway and Improves Functional Recovery after Spinal Cord Injury in Rats. — PubMed · 2020 · Journal Article The source marks this record as retracted.
- Simvastatin in an experimental spinal cord injury model: a histopathological and biochemical evidence based study. — PubMed · 2020 · Journal Article
- The Effect of Spinal Cord Injury on Beta-Amyloid Plaque Pathology in TgCRND8 Mouse Model of Alzheimer's Disease. — PubMed · 2020 · Journal Article
- Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury. — PubMed · 2019 · Journal Article
- A brief period of moderate noxious stimulation induces hemorrhage and impairs locomotor recovery after spinal cord injury. — PubMed · 2019 · Journal Article
- Angiopoietin-1 Protects Spinal Cord Ischemia and Reperfusion Injury by Inhibiting Autophagy in Rats. — PubMed · 2019 · Journal Article
- Effect of curcumin on the inflammatory reaction and functional recovery after spinal cord injury in a hyperglycemic rat model. — PubMed · 2019 · Journal Article
- Galantamine improves functional recovery and reduces lesion size in a rat model of spinal cord injury. — PubMed · 2019 · Journal Article
- Neuroprotective effects of P7C3 against spinal cord injury in rats. — PubMed · 2019 · Journal Article
- Protective effects of dantrolene and methylprednisolone against spinal cord injury-induced early oxidative damage in rabbit bladder: A comparative experimental study. — PubMed · 2019 · Journal Article
- Therapeutic hypothermia effectively reduces elevated extracellular ascorbate concentrations caused by acute spinal cord injury. — PubMed · 2019 · Journal Article
- Transcriptomic analysis of α-synuclein knockdown after T3 spinal cord injury in rats. — PubMed · 2019 · Journal Article
- The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview. — PubMed · 2019 · Journal Article
- Roles of extra-cellular signal-regulated protein kinase 5 signaling pathway in the development of spinal cord injury. — PubMed · 2019 · Journal Article
- Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice. — PubMed · 2019 · Journal Article
- Berberine enhances survival and axonal regeneration of motoneurons following spinal root avulsion and re-implantation in rats. — PubMed · 2019 · Journal Article
- Neuroectodermal Stem Cells Grafted into the Injured Spinal Cord Induce Both Axonal Regeneration and Morphological Restoration via Multiple Mechanisms. — PubMed · 2019 · Journal Article
- Pigment Epithelium-Derived Factor Promotes Axon Regeneration and Functional Recovery After Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Trehalose protects against spinal cord injury through regulating heat shock proteins 27 and 70 and caspase-3 genes expression. — PubMed · 2019 · Journal Article
- Cellular Inflammatory Response of the Spleen After Acute Spinal Cord Injury in Rat. — PubMed · 2019 · Journal Article
- Investigation of the neuroprotective effects of thymoquinone on rat spinal cord exposed to 900 MHz electromagnetic field. — PubMed · 2019 · Journal Article
- Neuroprotective role of icariin in experimental spinal cord injury via its antioxidant, anti‑neuroinflammatory and anti‑apoptotic properties. — PubMed · 2019 · Journal Article
- Regeneration of Denervated Skeletal Muscles - Brunelli's CNS-PNS Paradigm. — PubMed · 2019 · Journal Article
- CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells. — PubMed · 2019 · Journal Article
- An Accurate Method for Histological Determination of Neural Tissue Loss/Sparing after Compression-Induced Spinal Cord Injury with Optimal Reproducibility. — PubMed · 2019 · Journal Article
- Bisperoxovanadium Mediates Neuronal Protection through Inhibition of PTEN and Activation of PI3K/AKT-mTOR Signaling after Traumatic Spinal Injuries. — PubMed · 2019 · Journal Article
- Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice. — PubMed · 2019 · Journal Article
- Repositioning Flubendazole for Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Regenerative Effect of Growth Hormone (GH) in the Retina after Kainic Acid Excitotoxic Damage. — PubMed · 2019 · Journal Article
- [Effects of acetyl-L-carnitine on the recovery of hindlimb movement afterspinal cord injury in rats and its mechamism]. — PubMed · 2019 · Journal Article
- Brilliant Blue G Inhibits Inflammasome Activation and Reduces Disruption of Blood-Spinal Cord Barrier Induced by Spinal Cord Injury in Rats. — PubMed · 2019 · Journal Article
- Administration of ONO-2506 suppresses neuropathic pain after spinal cord injury by inhibition of astrocytic activation. — PubMed · 2019 · Journal Article
- Effect of M2 macrophage adoptive transfer on transcriptome profile of injured spinal cords in rats. — PubMed · 2019 · Journal Article
- Melatonin Enhances Autophagy and Reduces Apoptosis to Promote Locomotor Recovery in Spinal Cord Injury via the PI3K/AKT/mTOR Signaling Pathway. — PubMed · 2019 · Journal Article
- Neuroprotective effect of omega-3 fatty acids on spinal cord injury induced rats. — PubMed · 2019 · Journal Article
- Toll-like receptor 9 antagonism modulates astrocyte function and preserves proximal axons following spinal cord injury. — PubMed · 2019 · Journal Article
- Thymosin beta 4 attenuates oxidative stress-induced injury of spinal cord-derived neural stem/progenitor cells through the TLR4/MyD88 pathway. — PubMed · 2019 · Journal Article
- Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury. — PubMed · 2019 · Journal Article
- cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury. — PubMed · 2019 · Journal Article
- A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function. — PubMed · 2019 · Journal Article
- Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury. — PubMed · 2019 · Journal Article
- Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages. — PubMed · 2019 · Journal Article
- Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis. — PubMed · 2019 · Journal Article
- Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta-analysis and systematic review. — PubMed · 2019 · Journal Article
- Enhancing the expression of neurotrophic factors in epidermal neural crest stem cells by valproic acid: A potential candidate for combinatorial treatment. — PubMed · 2019 · Journal Article
- Plasticity Induced Recovery of Breathing Occurs at Chronic Stages after Cervical Contusion. — PubMed · 2019 · Journal Article
- BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury. — PubMed · 2019 · Journal Article
- A Causal Relationship in Spinal Cord Injury Rat Model Between Microglia Activation and EGFR/MAPK Detected by Overexpression of MicroRNA-325-3p. — PubMed · 2019 · Journal Article
- Sodium Butyrate Exerts Neuroprotective Effects in Spinal Cord Injury. — PubMed · 2019 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])