A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- The effects of N-acetyl-cysteine and acetyl-L-carnitine on neural survival, neuroinflammation and regeneration following spinal cord injury. — PubMed · 2014 · Journal Article
- Complement C5a is detrimental to histological and functional locomotor recovery after spinal cord injury in mice. — PubMed · 2014 · Journal Article
- Immunohistochemical analysis of activin A expression in spinal cords of rats with clip compression injuries. — PubMed · 2014 · Journal Article
- Riluzole effects on behavioral sensitivity and the development of axonal damage and spinal modifications that occur after painful nerve root compression. — PubMed · 2014 · Journal Article
- The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. — PubMed · 2014 · Journal Article
- tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury. — PubMed · 2014 · Journal Article
- Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury. — PubMed · 2014 · Journal Article
- Ischemic preconditioning enhances autophagy but suppresses autophagic cell death in rat spinal neurons following ischemia-reperfusion. — PubMed · 2014 · Journal Article
- Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. — PubMed · 2014 · Journal Article
- Neuroprotective effect of the proanthocyanidin-rich fraction in experimental model of spinal cord injury. — PubMed · 2014 · Journal Article
- Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation. — PubMed · 2014 · Journal Article
- Salvianolic acid B attenuates spinal cord ischemia-reperfusion-induced neuronal injury and oxidative stress by activating the extracellular signal-regulated kinase pathway in rats. — PubMed · 2014 · Journal Article
- Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury. — PubMed · 2014 · Journal Article
- Protective effects of hyperbaric oxygen treatment against spinal cord injury in rats via toll-like receptor 2/nuclear factor-κB signaling. — PubMed · 2014 · Journal Article
- Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury. — PubMed · 2014 · Journal Article
- Neuroprotective effect of apigenin in rats after contusive spinal cord injury. — PubMed · 2014 · Journal Article
- Neuroprotective role of hydralazine in rat spinal cord injury-attenuation of acrolein-mediated damage. — PubMed · 2014 · Journal Article
- Tert-butylhydroquinone protects the spinal cord against inflammatory response produced by spinal cord injury. — PubMed · 2014 · Journal Article
- Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage. — PubMed · 2014 · Journal Article
- SCO-spondin derived peptide NX210 induces neuroprotection in vitro and promotes fiber regrowth and functional recovery after spinal cord injury. — PubMed · 2014 · Journal Article
- Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury. — PubMed · 2014 · Journal Article
- Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury. — PubMed · 2014 · Journal Article
- Arundic acid (ONO-2506) inhibits secondary injury and improves motor function in rats with spinal cord injury. — PubMed · 2014 · Journal Article
- Curcumin promotes the spinal cord repair via inhibition of glial scar formation and inflammation. — PubMed · 2014 · Journal Article
- Chronic ibuprofen administration reduces neuropathic pain but does not exert neuroprotection after spinal cord injury in adult rats. — PubMed · 2014 · Journal Article
- Effects of cilostazol on oxidative stress, systemic cytokine release, and spinal cord injury in a rat model of transient aortic occlusion. — PubMed · 2014 · Journal Article
- (-)-Epigallocatechin-3-gallate (EGCG) modulates neurological function when intravenously infused in acute and, chronically injured spinal cord of adult rats. — PubMed · 2014 · Journal Article
- Neuroprotective effects of perflurocarbon (oxycyte) after contusive spinal cord injury. — PubMed · 2014 · Journal Article
- Neuroprotective ferulic acid (FA)-glycol chitosan (GC) nanoparticles for functional restoration of traumatically injured spinal cord. — PubMed · 2014 · Journal Article
- Perfusion imaging of spinal cord contusion: injury-induced blockade and partial reversal by β2-agonist treatment in rats. — PubMed · 2014 · Journal Article
- Spatial and temporal expression levels of specific microRNAs in a spinal cord injury mouse model and their relationship to the duration of compression. — PubMed · 2014 · Comparative Study
- The cancer drug tamoxifen: a potential therapeutic treatment for spinal cord injury. — PubMed · 2014 · Journal Article
- The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair. — PubMed · 2014 · Journal Article
- MiR-7-1 potentiated estrogen receptor agonists for functional neuroprotection in VSC4.1 motoneurons. — PubMed · 2014 · Journal Article
- Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats. — PubMed · 2014 · Journal Article
- Neuroprotective effects of autophagy induced by rapamycin in rat acute spinal cord injury model. — PubMed · 2014 · Journal Article
- Oscillating field stimulation promotes spinal cord remyelination by inducing differentiation of oligodendrocyte precursor cells after spinal cord injury. — PubMed · 2014 · Journal Article
- Simulation of injury potential compensation by direct current stimulation in rat spinal cord. — PubMed · 2014 · Journal Article
- Systematic administration of B vitamins attenuates neuropathic hyperalgesia and reduces spinal neuron injury following temporary spinal cord ischaemia in rats. — PubMed · 2014 · Journal Article
- The neuroprotective effect of treatment with curcumin in acute spinal cord injury: laboratory investigation. — PubMed · 2014 · Comparative Study
- Comparison of deferoxamine and methylprednisolone: protective effect of pharmacological agents on lipid peroxidation in spinal cord injury in rats. — PubMed · 2013 · Comparative Study
- Hyperbaric oxygen alleviates experimental (spinal cord) injury by downregulating HMGB1/NF-κB expression. — PubMed · 2013 · Journal Article
- Cyclic AMP promotes axon regeneration, lesion repair and neuronal survival in lampreys after spinal cord injury. — PubMed · 2013 · Journal Article
- Histopathological investigation of neuroprotective effects of Nigella sativa on motor neurons anterior horn spinal cord after sciatic nerve crush in rats. — PubMed · 2013 · Journal Article
- Osthole attenuates spinal cord ischemia-reperfusion injury through mitochondrial biogenesis-independent inhibition of mitochondrial dysfunction in rats. — PubMed · 2013 · Journal Article
- Phagocytic microglial phenotype induced by glibenclamide improves functional recovery but worsens hyperalgesia after spinal cord injury in adult rats. — PubMed · 2013 · Journal Article
- RS-Glucoraphanin bioactivated with myrosinase treatment counteracts proinflammatory cascade and apoptosis associated to spinal cord injury in an experimental mouse model. — PubMed · 2013 · Journal Article
- Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. — PubMed · 2013 · Journal Article
- Rosuvastatin may have neuroprotective effect on spinal cord ischemia reperfusion injury. — PubMed · 2013 · Journal Article
- The protective effect of salvianolic acid B on blood-spinal cord barrier after compression spinal cord injury in rats. — PubMed · 2013 · Journal Article
- Prophylactic neuroprotection with A91 improves the outcome of spinal cord injured rats. — PubMed · 2013 · Journal Article
- [Effect of curcumin on calcitionin gene related peptide expression after spinal cord injury in rats]. — PubMed · 2013 · Journal Article
- Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity. — PubMed · 2013 · Journal Article
- Systemic iron chelation results in limited functional and histological recovery after traumatic spinal cord injury in rats. — PubMed · 2013 · Journal Article
- Valproic acid protection against the brachial plexus root avulsion-induced death of motoneurons in rats. — PubMed · 2013 · Comparative Study
- Intraparenchymal microdialysis after acute spinal cord injury reveals differential metabolic responses to contusive versus compressive mechanisms of injury. — PubMed · 2013 · Comparative Study
- A self-assembling peptide reduces glial scarring, attenuates post-traumatic inflammation and promotes neurological recovery following spinal cord injury. — PubMed · 2013 · Journal Article
- Effect of preconditioning with hyperbaric oxygen on neural cell apoptosis after spinal cord injury in rats. — PubMed · 2013 · Journal Article
- [Expressions and implications of Th1/Th2 cytokines in injured rat brain and spinal cord]. — PubMed · 2013 · English Abstract
- Mobilisation of the splenic monocyte reservoir and peripheral CX₃CR1 deficiency adversely affects recovery from spinal cord injury. — PubMed · 2013 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])