A subject this map covers
Neuroprotection
What belongs here
Attempts to stop the second, delayed wave of damage in the first hours and days.
What does not belong here, however close it looks
Restoring function lost months earlier is repair, not neuroprotection.
What has been looked at
Counted from what the sources catalogue, not from reading the work. It says how much exists and over what span of years — never what any of it found.
- Registered or indexed as work in people: 1169 records · 1978–2027
- Indexed as work in animals: 1885 records · 1977–2026
- Indexed as laboratory work: 80 records · 1996–2026
- The source has not said who or what was studied: 572 records · 1991–2026
- No matching published catalogue records are linked above. Human-review status must be checked on the evidence itself.
Published in this map
Catalogue records matching this subject. Publication here does not establish human review, measured results or effectiveness. Open a record to inspect its sources and evidence.
No published catalogue records match this subject yet.
This is a result within this map, not a claim that no research exists. The source records below can help you continue searching.
Found in the scientific sources, not yet checked
Titles and identifiers as the sources publish them. Nobody here has read these papers, and nothing on this shelf is a result, a recommendation or evidence that anything works. Each line opens the original.
3706 records
This grouping is the source's own cataloguing, not a reading of the paper. It says where a record was filed, not what it found.
Indexed as work in animals
- Activation of dendritic-like cells and neural stem/progenitor cells in injured spinal cord by GM-CSF. — PubMed · 2009 · Journal Article
- Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. — PubMed · 2009 · Journal Article
- Immunomodulation of acute experimental spinal cord injury with human immunoglobulin G. — PubMed · 2009 · Journal Article
- Magnesium efficacy in a rat spinal cord injury model. — PubMed · 2009 · Journal Article
- Atorvastatin prevents early apoptosis after thoracic spinal cord contusion injury and promotes locomotion recovery. — PubMed · 2009 · Journal Article
- Ephedra sinica inhibits complement activation and improves the motor functions after spinal cord injury in rats. — PubMed · 2009 · Journal Article
- A new paradigm for local and sustained release of therapeutic molecules to the injured spinal cord for neuroprotection and tissue repair. — PubMed · 2009 · Journal Article
- Does dexmedetomidine reduce secondary damage after spinal cord injury? An experimental study. — PubMed · 2009 · Journal Article
- Neuroprotective effects of infliximab in experimental spinal cord injury. — PubMed · 2009 · Comparative Study
- Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury. — PubMed · 2009 · Journal Article
- Protection in animal models of brain and spinal cord injury with mild to moderate hypothermia. — PubMed · 2009 · Journal Article
- The neuroprotective and anti-inflammatory effects of diltiazem in spinal cord ischaemia-reperfusion injury. — PubMed · 2009 · Journal Article
- STAT5 mediates antiapoptotic effects of methylprednisolone on oligodendrocytes. — PubMed · 2009 · Journal Article
- Stem cell factor prevents neuronal cell apoptosis after acute spinal cord injury. — PubMed · 2009 · Journal Article
- Proteomic profiling of the insoluble pellets of the transected rat spinal cord. — PubMed · 2009 · Journal Article
- Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis. — PubMed · 2009 · Journal Article
- De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. — PubMed · 2009 · Journal Article
- Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. — PubMed · 2009 · Journal Article
- Differential effects of the mitochondrial uncoupling agent, 2,4-dinitrophenol, or the nitroxide antioxidant, Tempol, on synaptic or nonsynaptic mitochondria after spinal cord injury. — PubMed · 2009 · Journal Article
- Glial and axonal regeneration following spinal cord injury. — PubMed · 2009 · Journal Article
- Low-dose edaravone injection into the clamped aorta prevents ischemic spinal cord injury. — PubMed · 2009 · Journal Article
- The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury. — PubMed · 2008 · Journal Article
- PPARgamma agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms. — PubMed · 2008 · Journal Article
- A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model. — PubMed · 2008 · Journal Article
- Alpha4beta1 integrin blockade after spinal cord injury decreases damage and improves neurological function. — PubMed · 2008 · Journal Article
- An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury. — PubMed · 2008 · Journal Article
- Edaravone (MCI-186) scavenges reactive oxygen species and ameliorates tissue damage in the murine spinal cord injury model. — PubMed · 2008 · Journal Article
- Erythropoietin improves oxidative stress following spinal cord trauma in rats. — PubMed · 2008 · Journal Article
- Modulation of the secondary injury process after spinal cord injury in Bach1-deficient mice by heme oxygenase-1. — PubMed · 2008 · Journal Article
- Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage. — PubMed · 2008 · Journal Article
- Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. — PubMed · 2008 · Journal Article
- Effect of intrathecal papaverine on blood flow and secondary injury in injured cord. — PubMed · 2008 · Journal Article
- Effects of autoimmunity on recovery of function in adult rats following spinal cord injury. — PubMed · 2008 · Journal Article
- TGF-alpha increases astrocyte invasion and promotes axonal growth into the lesion following spinal cord injury in mice. — PubMed · 2008 · Journal Article
- Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury. — PubMed · 2008 · Journal Article
- Neuroprotective effects of caspase-3 inhibition on functional recovery and tissue sparing after acute spinal cord injury. — PubMed · 2008 · Comparative Study
- Stem cell delivery by lumbar puncture as a therapeutic alternative to direct injection into injured spinal cord. — PubMed · 2008 · Journal Article
- Therapeutic efficacy of SJA6017, a calpain inhibitor, in rat spinal cord injury. — PubMed · 2008 · Comparative Study
- Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: endogenous neuroprotection. — PubMed · 2008 · Journal Article
- FK1706, a novel non-immunosuppressant neurophilin ligand, ameliorates motor dysfunction following spinal cord injury through its neuroregenerative action. — PubMed · 2008 · Journal Article
- A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury. — PubMed · 2008 · Journal Article
- Dietary restriction started after spinal cord injury improves functional recovery. — PubMed · 2008 · Journal Article
- Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. — PubMed · 2008 · Journal Article
- Involvement of acidic fibroblast growth factor in spinal cord injury repair processes revealed by a proteomics approach. — PubMed · 2008 · Journal Article
- Neuroprotective effect of moderate epidural hypothermia after spinal cord injury in rats. — PubMed · 2008 · Journal Article
- Protective effect of C1 esterase inhibitor on acute traumatic spinal cord injury in the rat. — PubMed · 2008 · Journal Article
- Biogenic amines in the reduction of oxidative stress: melatonin and its metabolites. — PubMed · 2008 · Journal Article
- Inhibition of MMP2/MMP9 after spinal cord trauma reduces apoptosis. — PubMed · 2008 · Comparative Study
- Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. — PubMed · 2008 · Comparative Study
- Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury. — PubMed · 2008 · Journal Article
- Adenovirus-mediated retrograde transfer of neurotrophin-3 gene enhances survival of anterior horn neurons of twy/twy mice with chronic mechanical compression of the spinal cord. — PubMed · 2008 · Comparative Study
- Aortic cross-clamping-induced spinal cord oxidative stress in rabbits: the role of a novel antioxidant adrenomedullin. — PubMed · 2008 · Journal Article
- Glucocorticoid-induced tumor necrosis factor receptor-related (GITR)-Fc fusion protein inhibits GITR triggering and protects from the inflammatory response after spinal cord injury. — PubMed · 2008 · Journal Article
- Pregabalin as a neuroprotector after spinal cord injury in rats. — PubMed · 2008 · Journal Article
- Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease. — PubMed · 2008 · Journal Article
- Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. — PubMed · 2008 · Journal Article
- Effects of activated protein C on neonatal hypoxic ischemic brain injury. — PubMed · 2008 · Journal Article
- Delayed treatment of spinal cord injury with erythropoietin or darbepoetin--a lack of neuroprotective efficacy in a contusion model of cord injury. — PubMed · 2008 · Journal Article
- Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats. — PubMed · 2008 · Journal Article
- Protective effect of ketamine on ischemic spinal cord injury in rabbits. — PubMed · 2008 · Journal Article
Where this was looked for, and when
The latest collection walk and the accumulated shelf have different scopes. A zero applies only to that source query and its date window; older records may remain on the shelf. It does not mean no research exists.
| ClinicalTrials.gov | latest collection walk returned no records | asked on 2026-10-05 Collection window: 2026-09-16 – 2026-10-05 | matched in this collection walk 0 · accumulated records across collection walks 6 · still to fetch in this walk 0 | aim: every record matching this question |
|---|---|---|---|---|
| Crossref | asked, and it answered | asked on 2026-09-16 Collection window: all dates before the end date – 2026-09-16 | matched in this collection walk 1230843 · accumulated records across collection walks 50 | aim: a sample of the most relevant records. This source ranks a bag of words, so its own total is the size of the corpus that shares some of them, never a set still owed. |
| PubMed | asked, and it answered | asked on 2026-09-17 Collection window: all dates before the end date – 2026-09-17 | matched in this collection walk 3744 · accumulated records across collection walks 3744 · still to fetch in this walk 0 | aim: every record matching this question |
The question asked
- ClinicalTrials.gov
("neuroprotection" OR "secondary injury") - Crossref
spinal cord injury neuroprotection secondary injury - PubMed
("Spinal Cord Injuries"[MeSH Terms] OR "spinal cord injury"[Title/Abstract] OR "spinal cord injuries"[Title/Abstract] OR "spinal cord trauma"[Title/Abstract]) AND ("Neuroprotection"[MeSH Terms] OR "Neuroprotective Agents"[MeSH Terms] OR "neuroprotection"[Title/Abstract] OR "secondary injury"[Title/Abstract])